TrAC - Trends in Analytical Chemistry, volume 143, pages 116375

Gut microbiota-related metabolome analysis based on chromatography-mass spectrometry

Lina Zhou ¹

Di Yu ^{2, 3}

Sijia Zheng ^{2, 3}

Runze Ouyang ^{2, 3}

Yuting Wang ^{2, 3}

Guowang Xu ¹

Hide authors affiliations Show authors affiliations: 3 affiliations

CAS Key Laboratory of Separation Science for Analytical Chemistry , Dalian Institute of Chemical Physics, Chinese Academy of Sciences , Dalian 116023 , China. |

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China |

University of Chinese Academy of sciences, Beijing 100049, China |

Publication type: Journal Article

Publication date: 2021-10-01

Elsevier

Journal: TrAC - Trends in Analytical Chemistry

Quartile SCImago

Quartile WOS

Impact factor: 13.1

ISSN: 01659936

DOI: 10.1016/j.trac.2021.116375

Copy DOI

Spectroscopy

Analytical Chemistry

Abstract

Gut microbiota can either contribute to the host development and health, or lead to the pathogenesis of various diseases in the case of imbalance. Microbial metabolites can act as functional molecules in mediating microbiota-host cross-talk and modulating host phenotype. There is an increasing demand for metabolomics. This review firstly summarizes the general scheme and methods for identifying important gut microbiota derived metabolites related to health and disease by integrating metabolomics and gut microbiome. And then chromatography-mass spectrometry-based methods for microbiota related metabolite analysis are reviewed. Representative methods developed in the past decade are highlighted mainly with respect to targeted analysis and non-targeted analysis. The former deals with short chain fatty acids, bile acids, tryptophan-related metabolites, and methylamines, and the latter includes sample collection and preparation, separation, detection and metabolite structure annotation. Perspectives on the future directions and challenges of metabolomics in microbiota-related host health/disease studies are also presented. • Gut microbiota can modulate host phenotype through functional microbial metabolites. • Chromatography-mass spectrometry based metabolomics is being widely used in microbiota related studies. • Important microbial metabolites are summarized and their targeted analyses in different sample types are given. • Metabolomics progress in sample preparation, separation, detection and metabolite feature annotation is presented. • The challenges and future development of metabolomics in gut microbiota field are given.

By date By citations

Top-30

Citations by journals

	1
Molecules	Molecules, 1, 6.67% Molecules 1 publication, 6.67%
Analytical and Bioanalytical Chemistry	Analytical and Bioanalytical Chemistry, 1, 6.67% Analytical and Bioanalytical Chemistry 1 publication, 6.67%
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences	Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 1, 6.67% Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 1 publication, 6.67%
Food Bioscience	Food Bioscience, 1, 6.67% Food Bioscience 1 publication, 6.67%
Journal of the American Society for Mass Spectrometry	Journal of the American Society for Mass Spectrometry, 1, 6.67% Journal of the American Society for Mass Spectrometry 1 publication, 6.67%
TrAC - Trends in Analytical Chemistry	TrAC - Trends in Analytical Chemistry, 1, 6.67% TrAC - Trends in Analytical Chemistry 1 publication, 6.67%
Frontiers in Oncology	Frontiers in Oncology, 1, 6.67% Frontiers in Oncology 1 publication, 6.67%
Computational and Structural Biotechnology Journal	Computational and Structural Biotechnology Journal, 1, 6.67% Computational and Structural Biotechnology Journal 1 publication, 6.67%
Pharmaceuticals	Pharmaceuticals, 1, 6.67% Pharmaceuticals 1 publication, 6.67%
Contemporary Clinical Neuroscience	Contemporary Clinical Neuroscience, 1, 6.67% Contemporary Clinical Neuroscience 1 publication, 6.67%
International Journal of Biological Macromolecules	International Journal of Biological Macromolecules, 1, 6.67% International Journal of Biological Macromolecules 1 publication, 6.67%
Russian Chemical Reviews	Russian Chemical Reviews, 1, 6.67% Russian Chemical Reviews 1 publication, 6.67%
Current Issues in Molecular Biology	Current Issues in Molecular Biology, 1, 6.67% Current Issues in Molecular Biology 1 publication, 6.67%
	1

Citations by publishers

	1 2 3 4 5
Elsevier	Elsevier, 5, 33.33% Elsevier 5 publications, 33.33%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 3, 20% Multidisciplinary Digital Publishing Institute (MDPI) 3 publications, 20%
Springer Nature	Springer Nature, 2, 13.33% Springer Nature 2 publications, 13.33%
American Chemical Society (ACS)	American Chemical Society (ACS), 1, 6.67% American Chemical Society (ACS) 1 publication, 6.67%
Frontiers Media S.A.	Frontiers Media S.A., 1, 6.67% Frontiers Media S.A. 1 publication, 6.67%
Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii	Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii, 1, 6.67% Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii 1 publication, 6.67%
Research Square Platform LLC	Research Square Platform LLC, 1, 6.67% Research Square Platform LLC 1 publication, 6.67%
	1 2 3 4 5

We do not take into account publications without a DOI.
Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
Statistics recalculated weekly.

{"yearsCitations":{"type":"bar","data":{"show":true,"labels":[2022,2023,2024],"ids":[0,0,0],"codes":[0,0,0],"imageUrls":["","",""],"datasets":[{"label":"Citations number","data":[3,8,4],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6"],"percentage":["20","53.33","26.67"],"barThickness":null}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"journals":{"type":"bar","data":{"show":true,"labels":["Molecules","Analytical and Bioanalytical Chemistry","Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences","Food Bioscience","Journal of the American Society for Mass Spectrometry","TrAC - Trends in Analytical Chemistry","Frontiers in Oncology","Computational and Structural Biotechnology Journal","Pharmaceuticals","Contemporary Clinical Neuroscience","International Journal of Biological Macromolecules","Russian Chemical Reviews","Current Issues in Molecular Biology"],"ids":[1770,10563,21152,1959,15911,434,10990,4268,1203,38837,23035,23802,7942],"codes":[0,0,0,0,0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/9Mus3KG1Tkd7Bwaurt8H3RwWh0CxRlGoO6ng9UK1_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp"],"datasets":[{"label":"","data":[1,1,1,1,1,1,1,1,1,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[6.67,6.67,6.67,6.67,6.67,6.67,6.67,6.67,6.67,6.67,6.67,6.67,6.67],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Journals","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"publishers":{"type":"bar","data":{"show":true,"labels":["Elsevier","Multidisciplinary Digital Publishing Institute (MDPI)","Springer Nature","American Chemical Society (ACS)","Frontiers Media S.A.","Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii","Research Square Platform LLC"],"ids":[17,202,8,40,208,9422,9418],"codes":[0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/9Mus3KG1Tkd7Bwaurt8H3RwWh0CxRlGoO6ng9UK1_medium.webp",""],"datasets":[{"label":"","data":[5,3,2,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[33.33,20,13.33,6.67,6.67,6.67,6.67],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":false}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Publishers","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"yearsCitationsQuartiles":{"type":"bar","data":{"show":true,"labels":[2022,2023,2024],"ids":[],"codes":[],"imageUrls":[],"datasets":[{"label":"Q4","backgroundColor":"rgb(221,90,78)","data":[0,0,0],"percentage":["0","0","0"]},{"label":"Q3","backgroundColor":"rgb(251, 163,83)","data":[0,0,0],"percentage":["0","0","0"]},{"label":"Q2","backgroundColor":"rgb(232, 213, 89)","data":[1,2,1],"percentage":["6.67","13.33","6.67"]},{"label":"Q1","backgroundColor":"rgb(164, 207, 99)","data":[1,5,2],"percentage":["6.67","33.33","13.33"]},{"label":"Quartile not defined","backgroundColor":"#E5E7EB","data":[1,1,1],"percentage":["6.67","6.67","6.67"]}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":true},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":true}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations quartiles by SCImago per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"yearsCitationsQuartilesWs":{"type":"bar","data":{"show":true,"labels":[2022,2023,2024],"ids":[],"codes":[],"imageUrls":[],"datasets":[{"label":"Q4","backgroundColor":"rgb(221,90,78)","data":[0,0,0],"percentage":["0","0","0"]},{"label":"Q3","backgroundColor":"rgb(251, 163,83)","data":[0,0,1],"percentage":["0","0","6.67"]},{"label":"Q2","backgroundColor":"rgb(232, 213, 89)","data":[1,3,0],"percentage":["6.67","20","0"]},{"label":"Q1","backgroundColor":"rgb(164, 207, 99)","data":[1,4,2],"percentage":["6.67","26.67","13.33"]},{"label":"Quartile not defined","backgroundColor":"#E5E7EB","data":[1,1,1],"percentage":["6.67","6.67","6.67"]}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":true},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"},"stacked":true}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations quartiles by WoS per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}}}

Are you a researcher?

Create a profile to get free access to personal recommendations for colleagues and new articles.

Metrics

Cite this

GOST |

Cite this

GOST Copy

Zhou L. et al. Gut microbiota-related metabolome analysis based on chromatography-mass spectrometry // TrAC - Trends in Analytical Chemistry. 2021. Vol. 143. p. 116375.

GOST all authors (up to 50) Copy

Zhou L., Yu D., Zheng S., Ouyang R., Wang Y., Xu G. Gut microbiota-related metabolome analysis based on chromatography-mass spectrometry // TrAC - Trends in Analytical Chemistry. 2021. Vol. 143. p. 116375.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1016/j.trac.2021.116375

UR - https://doi.org/10.1016/j.trac.2021.116375

TI - Gut microbiota-related metabolome analysis based on chromatography-mass spectrometry

T2 - TrAC - Trends in Analytical Chemistry

AU - Zhou, Lina

AU - Yu, Di

AU - Zheng, Sijia

AU - Ouyang, Runze

AU - Wang, Yuting

AU - Xu, Guowang

PY - 2021

DA - 2021/10/01 00:00:00

PB - Elsevier

SP - 116375

VL - 143

SN - 0165-9936

ER -

BibTex

Cite this

BibTex Copy

@article{2021_Zhou,

author = {Lina Zhou and Di Yu and Sijia Zheng and Runze Ouyang and Yuting Wang and Guowang Xu},

title = {Gut microbiota-related metabolome analysis based on chromatography-mass spectrometry},

journal = {TrAC - Trends in Analytical Chemistry},

year = {2021},

volume = {143},

publisher = {Elsevier},

month = {oct},

url = {https://doi.org/10.1016/j.trac.2021.116375},

pages = {116375},

doi = {10.1016/j.trac.2021.116375}

}

Found error?

Publisher

Elsevier

Journal

TrAC - Trends in Analytical Chemistry

Quartile SCImago

Quartile WOS

Impact factor

13.1

ISSN

01659936 (Print)