Open Access
Translational Oncology, volume 14, issue 7, pages 101090
Non-coding RNAs in pancreatic ductal adenocarcinoma: New approaches for better diagnosis and therapy
Mortoglou Maria
1
,
Tabin Zoey Kathleen
2
,
ARISAN E.D.
3
,
Kocher Hemant M
4
,
Uysal-Onganer Pinar
5
1
Cancer Research Group, School of Life Sciences, University of Westminster, London W1W 6UW, UK. Electronic address: w1754188@my.westminster.ac.uk.
2
Cancer Research Group, School of Life Sciences, University of Westminster, London W1W 6UW, UK. Electronic address: zoey.tabin@icloud.com.
5
Cancer Research Group, School of Life Sciences, University of Westminster, London W1W 6UW, UK. Electronic address: p.onganer@westminster.ac.uk.
Publication type: Journal Article
Publication date: 2021-07-01
PubMed ID:
33831655
Cancer Research
Oncology
Abstract
• Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies, which is usually diagnosed at an advanced stage. • Non-coding RNAs (ncRNAs) have been recognized to play a central role in PDAC pathogenesis and could be used as biomarkers for PDAC. • microRNAs (miRs) can act either as oncogenes or tumour suppressors in PDAC. • Long non-coding RNAs (lncRNAs) are around 25% of the total RNA distribution in the human cell and their deregulation is widely implicated in PDAC carcinogenesis. • Circular RNAs (circRNAs) can be potential novel biomarkers and therapeutic targets for PDAC diagnosis and treatment via their function as miR molecular "sponges", RNA-binding protein (RBP) sponges, protein translators and gene transcription regulators. Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive malignancies with a 5-year survival rate less than 8%, which has remained unchanged over the last 50 years. Early detection is particularly difficult due to the lack of disease-specific symptoms and a reliable biomarker. Multimodality treatment including chemotherapy, radiotherapy (used sparingly) and surgery has become the standard of care for patients with PDAC. Carbohydrate antigen 19–9 (CA 19–9) is the most common diagnostic biomarker; however, it is not specific enough especially for asymptomatic patients. Non-coding RNAs are often deregulated in human malignancies and shown to be involved in cancer-related mechanisms such as cell growth, differentiation, and cell death. Several micro, long non-coding and circular RNAs have been reported to date which are involved in PDAC. Aim of this review is to discuss the roles and functions of non-coding RNAs in diagnosis and treatments of PDAC.
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- We do not take into account publications that without a DOI.
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- Statistics recalculated weekly.
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Mortoglou M. et al. Non-coding RNAs in pancreatic ductal adenocarcinoma: New approaches for better diagnosis and therapy // Translational Oncology. 2021. Vol. 14. No. 7. p. 101090.
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Mortoglou M., Tabin Z. K., ARISAN E., Kocher H. M., Uysal-Onganer P. Non-coding RNAs in pancreatic ductal adenocarcinoma: New approaches for better diagnosis and therapy // Translational Oncology. 2021. Vol. 14. No. 7. p. 101090.
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TY - JOUR
DO - 10.1016/j.tranon.2021.101090
UR - https://doi.org/10.1016%2Fj.tranon.2021.101090
TI - Non-coding RNAs in pancreatic ductal adenocarcinoma: New approaches for better diagnosis and therapy
T2 - Translational Oncology
AU - Mortoglou, Maria
AU - Tabin, Zoey Kathleen
AU - ARISAN, E.D.
AU - Kocher, Hemant M
AU - Uysal-Onganer, Pinar
PY - 2021
DA - 2021/07/01 00:00:00
PB - Neoplasia Press
SP - 101090
IS - 7
VL - 14
PMID - 33831655
SN - 1936-5233
ER -
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@article{2021_Mortoglou,
author = {Maria Mortoglou and Zoey Kathleen Tabin and E.D. ARISAN and Hemant M Kocher and Pinar Uysal-Onganer},
title = {Non-coding RNAs in pancreatic ductal adenocarcinoma: New approaches for better diagnosis and therapy},
journal = {Translational Oncology},
year = {2021},
volume = {14},
publisher = {Neoplasia Press},
month = {jul},
url = {https://doi.org/10.1016%2Fj.tranon.2021.101090},
number = {7},
pages = {101090},
doi = {10.1016/j.tranon.2021.101090}
}
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MLA
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Mortoglou, Maria, et al. “Non-coding RNAs in pancreatic ductal adenocarcinoma: New approaches for better diagnosis and therapy.” Translational Oncology, vol. 14, no. 7, Jul. 2021, p. 101090. https://doi.org/10.1016%2Fj.tranon.2021.101090.