Open Access
,
volume 4
,
issue 1
,
pages 575-590
Inflammation as a central mechanism in Alzheimer's disease
Publication type: Journal Article
Publication date: 2018-01-01
scimago Q1
wos Q1
SJR: 2.146
CiteScore: 11.5
Impact factor: 6.8
ISSN: 23528737
PubMed ID:
30406177
Psychiatry and Mental health
Neurology (clinical)
Abstract
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that is characterized by cognitive decline and the presence of two core pathologies, amyloid β plaques and neurofibrillary tangles. Over the last decade, the presence of a sustained immune response in the brain has emerged as a third core pathology in AD. The sustained activation of the brain's resident macrophages (microglia) and other immune cells has been demonstrated to exacerbate both amyloid and tau pathology and may serve as a link in the pathogenesis of the disorder. In the following review, we provide an overview of inflammation in AD and a detailed coverage of a number of microglia-related signaling mechanisms that have been implicated in AD. Additional information on microglia signaling and a number of cytokines in AD are also reviewed. We also review the potential connection of risk factors for AD and how they may be related to inflammatory mechanisms.
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GOST
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Kinney J. W. et al. Inflammation as a central mechanism in Alzheimer's disease // Alzheimer's and Dementia: Translational Research and Clinical Interventions. 2018. Vol. 4. No. 1. pp. 575-590.
GOST all authors (up to 50)
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Kinney J. W., Bemiller S. M., Murtishaw A. S., Leisgang A. M., Salazar A. M., Lamb B. T. Inflammation as a central mechanism in Alzheimer's disease // Alzheimer's and Dementia: Translational Research and Clinical Interventions. 2018. Vol. 4. No. 1. pp. 575-590.
Cite this
RIS
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TY - JOUR
DO - 10.1016/j.trci.2018.06.014
UR - https://doi.org/10.1016/j.trci.2018.06.014
TI - Inflammation as a central mechanism in Alzheimer's disease
T2 - Alzheimer's and Dementia: Translational Research and Clinical Interventions
AU - Kinney, Jefferson W.
AU - Bemiller, Shane M.
AU - Murtishaw, Andrew S.
AU - Leisgang, Amanda M
AU - Salazar, Arnold M
AU - Lamb, Bruce T.
PY - 2018
DA - 2018/01/01
PB - Elsevier
SP - 575-590
IS - 1
VL - 4
PMID - 30406177
SN - 2352-8737
ER -
Cite this
BibTex (up to 50 authors)
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@article{2018_Kinney,
author = {Jefferson W. Kinney and Shane M. Bemiller and Andrew S. Murtishaw and Amanda M Leisgang and Arnold M Salazar and Bruce T. Lamb},
title = {Inflammation as a central mechanism in Alzheimer's disease},
journal = {Alzheimer's and Dementia: Translational Research and Clinical Interventions},
year = {2018},
volume = {4},
publisher = {Elsevier},
month = {jan},
url = {https://doi.org/10.1016/j.trci.2018.06.014},
number = {1},
pages = {575--590},
doi = {10.1016/j.trci.2018.06.014}
}
Cite this
MLA
Copy
Kinney, Jefferson W., et al. “Inflammation as a central mechanism in Alzheimer's disease.” Alzheimer's and Dementia: Translational Research and Clinical Interventions, vol. 4, no. 1, Jan. 2018, pp. 575-590. https://doi.org/10.1016/j.trci.2018.06.014.