Journal of Pharmaceutical Sciences, volume 110, issue 4, pages 1533-1539
Exposing Hidden Conformations of Carbamazepine Appearing Due to Interaction With the Solid Phase by 2D 1H-15N HMBC NMR Spectroscopy
Publication type: Journal Article
Publication date: 2021-04-01
Journal:
Journal of Pharmaceutical Sciences
Quartile SCImago
Q2
Quartile WOS
Q2
Impact factor: 3.8
ISSN: 00223549, 15206017
Pharmaceutical Science
Abstract
Abstract
Two-dimensional 1H-15N HMBC NMR spectra of the well-known anticonvulsant carbamazepine dissolved in different organic solvents, recorded on an NMR spectrometer prove the existence of hidden conformers in saturated solutions. Obtained conformer distribution arises due to the presence of the solid phase in saturated solution. A weak influence of ring currents was revealed for different molecular conformations of carbamazepine dissolved in a saturated solution, which provides a simple approach to discovering hidden conformations. Hidden conformers were found in three different solvents: dimethyl sulfoxide, chloroform, and dichloromethane.Top-30
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Khodov I. A. et al. Exposing Hidden Conformations of Carbamazepine Appearing Due to Interaction With the Solid Phase by 2D 1H-15N HMBC NMR Spectroscopy // Journal of Pharmaceutical Sciences. 2021. Vol. 110. No. 4. pp. 1533-1539.
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Khodov I. A., Efimov S., Krestyaninov M., Kiselev M. Exposing Hidden Conformations of Carbamazepine Appearing Due to Interaction With the Solid Phase by 2D 1H-15N HMBC NMR Spectroscopy // Journal of Pharmaceutical Sciences. 2021. Vol. 110. No. 4. pp. 1533-1539.
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TY - JOUR
DO - 10.1016/j.xphs.2021.01.001
UR - https://linkinghub.elsevier.com/retrieve/pii/S002235492100006X
TI - Exposing Hidden Conformations of Carbamazepine Appearing Due to Interaction With the Solid Phase by 2D 1H-15N HMBC NMR Spectroscopy
T2 - Journal of Pharmaceutical Sciences
AU - Khodov, Ilya A.
AU - Efimov, Sergey
AU - Krestyaninov, Michael
AU - Kiselev, Michael
PY - 2021
DA - 2021/04/01
PB - Elsevier
SP - 1533-1539
IS - 4
VL - 110
SN - 0022-3549
SN - 1520-6017
ER -
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@article{2021_Khodov,
author = {Ilya A. Khodov and Sergey Efimov and Michael Krestyaninov and Michael Kiselev},
title = {Exposing Hidden Conformations of Carbamazepine Appearing Due to Interaction With the Solid Phase by 2D 1H-15N HMBC NMR Spectroscopy},
journal = {Journal of Pharmaceutical Sciences},
year = {2021},
volume = {110},
publisher = {Elsevier},
month = {apr},
url = {https://linkinghub.elsevier.com/retrieve/pii/S002235492100006X},
number = {4},
pages = {1533--1539},
doi = {10.1016/j.xphs.2021.01.001}
}
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Khodov, Ilya A., et al. “Exposing Hidden Conformations of Carbamazepine Appearing Due to Interaction With the Solid Phase by 2D 1H-15N HMBC NMR Spectroscopy.” Journal of Pharmaceutical Sciences, vol. 110, no. 4, Apr. 2021, pp. 1533-1539. https://linkinghub.elsevier.com/retrieve/pii/S002235492100006X.
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