Coordination Chemistry Reviews, volume 232, issue 1-2, pages 95-126
Copper complexes of non-steroidal anti-inflammatory drugs: an opportunity yet to be realized
Jane E. Weder
1
,
Carolyn T. Dillon
1
,
T. W. Hambley
1
,
Brendan Kennedy
1
,
Peter A. Lay
1
,
J.Ray Biffin
2
,
Hubert L. Regtop
2
,
Neal M Davies
3
2
Biochemical Veterinary Research Pty. Ltd., Braemar NSW 2575, Australia
|
Publication type: Journal Article
Publication date: 2002-10-10
Journal:
Coordination Chemistry Reviews
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 20.6
ISSN: 00108545
Materials Chemistry
Inorganic Chemistry
Physical and Theoretical Chemistry
Abstract
The proposed curative properties of Cu-based non-steroidal anti-inflammatory drugs (NSAIDs) have led to the development of numerous Cu(II) complexes of NSAIDs with enhanced anti-inflammatory activity and reduced gastrointestinal (GI) toxicity compared with their uncomplexed parent drug. These low toxicity Cu drugs have yet to reach an extended human market, but are of enormous interest, because many of today's anti-inflammatory drug therapies, including those based on the NSAIDs, remain either largely inadequate and/or are associated with problematic renal, GI and cardiovascular side effects. The origins of the anti-inflammatory and gastric-sparing actions of Cu-NSAIDs, however, remain uncertain. Their ability to influence copper metabolism has been a matter of debate and, apart from their frequently reported superoxide dismutase (SOD)-like activity in vitro, relatively little is known about how they ultimately regulate the inflammatory process and/or immune system. Furthermore, little is known of their pharmacokinetic and biodistribution profile in both humans and animals, stability in biological media and pharmaceutical formulations, or the relative potency/efficacy of the Cu(II) monomeric versus Cu(II) dimeric complexes. The following review will not only discuss the etiology of inflammation, factors influencing the metabolism of copper and historical overview of the development of the Cu-NSAIDs, but also outline the structural characteristics, medicinal and veterinary properties, and proposed modes of action of the Cu-NSAIDs. It will also compare the SOD, anti-inflammatory and ulcerogenic effects of various Cu-NSAIDs. If the potential opportunities of the Cu-NSAIDs are to be completely realized, a mechanistic understanding and delineation of their in vivo and in vitro pharmacological activity is fundamental, along with further characterization of their pharmacokinetic/pharmacodynamic disposition.
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Citations by publishers
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1 publication, 0.22%
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- We do not take into account publications without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Weder J. E. et al. Copper complexes of non-steroidal anti-inflammatory drugs: an opportunity yet to be realized // Coordination Chemistry Reviews. 2002. Vol. 232. No. 1-2. pp. 95-126.
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Weder J. E., Dillon C. T., Hambley T. W., Kennedy B., Lay P. A., Biffin J., Regtop H. L., Davies N. M. Copper complexes of non-steroidal anti-inflammatory drugs: an opportunity yet to be realized // Coordination Chemistry Reviews. 2002. Vol. 232. No. 1-2. pp. 95-126.
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TY - JOUR
DO - 10.1016/S0010-8545(02)00086-3
UR - https://doi.org/10.1016/S0010-8545(02)00086-3
TI - Copper complexes of non-steroidal anti-inflammatory drugs: an opportunity yet to be realized
T2 - Coordination Chemistry Reviews
AU - Weder, Jane E.
AU - Dillon, Carolyn T.
AU - Hambley, T. W.
AU - Kennedy, Brendan
AU - Lay, Peter A.
AU - Biffin, J.Ray
AU - Regtop, Hubert L.
AU - Davies, Neal M
PY - 2002
DA - 2002/10/10 00:00:00
PB - Elsevier
SP - 95-126
IS - 1-2
VL - 232
SN - 0010-8545
ER -
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@article{2002_Weder,
author = {Jane E. Weder and Carolyn T. Dillon and T. W. Hambley and Brendan Kennedy and Peter A. Lay and J.Ray Biffin and Hubert L. Regtop and Neal M Davies},
title = {Copper complexes of non-steroidal anti-inflammatory drugs: an opportunity yet to be realized},
journal = {Coordination Chemistry Reviews},
year = {2002},
volume = {232},
publisher = {Elsevier},
month = {oct},
url = {https://doi.org/10.1016/S0010-8545(02)00086-3},
number = {1-2},
pages = {95--126},
doi = {10.1016/S0010-8545(02)00086-3}
}
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MLA
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Weder, Jane E., et al. “Copper complexes of non-steroidal anti-inflammatory drugs: an opportunity yet to be realized.” Coordination Chemistry Reviews, vol. 232, no. 1-2, Oct. 2002, pp. 95-126. https://doi.org/10.1016/S0010-8545(02)00086-3.
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