Regio-selective hydroxysubstitution of fluorobenzoic acid derivatives: facile synthesis of fluorosalicylic acid derivatives
1
Research and Development Department, Ihara Chemical Industry Co. Ltd., Fujikawa-cho, Ihara-gun, Shizuoka 421-3306, Japan
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Publication type: Journal Article
Publication date: 2003-05-01
scimago Q3
wos Q3
SJR: 0.333
CiteScore: 3.7
Impact factor: 1.9
ISSN: 00221139, 18733328
Organic Chemistry
Biochemistry
Inorganic Chemistry
Physical and Theoretical Chemistry
Environmental Chemistry
Abstract
Ortho-substituted fluorine in 2,4-difluorobenzoic acid was found to be regio-selectively replaced to hydroxide by solid sodium hydroxide in 1,3-dimethyl-2-imidazolidinone, to afford 4-fluoro-2-hydroxybenzoic acid in high yield. Several multi-fluoro-substituted benzoic acid derivatives were effectively transformed to the corresponding salicylic acid derivatives under the similar conditions.
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11
Total citations:
11
Citations from 2024:
1
(9.09%)
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GOST
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Umezu K., Tabuchi F., Kimura Y. Regio-selective hydroxysubstitution of fluorobenzoic acid derivatives: facile synthesis of fluorosalicylic acid derivatives // Journal of Fluorine Chemistry. 2003. Vol. 121. No. 1. pp. 97-99.
GOST all authors (up to 50)
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Umezu K., Tabuchi F., Kimura Y. Regio-selective hydroxysubstitution of fluorobenzoic acid derivatives: facile synthesis of fluorosalicylic acid derivatives // Journal of Fluorine Chemistry. 2003. Vol. 121. No. 1. pp. 97-99.
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RIS
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TY - JOUR
DO - 10.1016/s0022-1139(02)00342-1
UR - https://doi.org/10.1016/s0022-1139(02)00342-1
TI - Regio-selective hydroxysubstitution of fluorobenzoic acid derivatives: facile synthesis of fluorosalicylic acid derivatives
T2 - Journal of Fluorine Chemistry
AU - Umezu, Kazuto
AU - Tabuchi, Fumiya
AU - Kimura, Yoshikazu
PY - 2003
DA - 2003/05/01
PB - Elsevier
SP - 97-99
IS - 1
VL - 121
SN - 0022-1139
SN - 1873-3328
ER -
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BibTex (up to 50 authors)
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@article{2003_Umezu,
author = {Kazuto Umezu and Fumiya Tabuchi and Yoshikazu Kimura},
title = {Regio-selective hydroxysubstitution of fluorobenzoic acid derivatives: facile synthesis of fluorosalicylic acid derivatives},
journal = {Journal of Fluorine Chemistry},
year = {2003},
volume = {121},
publisher = {Elsevier},
month = {may},
url = {https://doi.org/10.1016/s0022-1139(02)00342-1},
number = {1},
pages = {97--99},
doi = {10.1016/s0022-1139(02)00342-1}
}
Cite this
MLA
Copy
Umezu, Kazuto, et al. “Regio-selective hydroxysubstitution of fluorobenzoic acid derivatives: facile synthesis of fluorosalicylic acid derivatives.” Journal of Fluorine Chemistry, vol. 121, no. 1, May. 2003, pp. 97-99. https://doi.org/10.1016/s0022-1139(02)00342-1.