Tetrahedron Letters, volume 42, issue 7, pages 1363-1365
Polymer-assisted solution-phase library synthesis of 4-alkoxy-2-hydroxy-3,5,6-trifluorobenzoic acids
1
CRC Centre for Cancer Therapeutics at the Institute of Cancer Research, Cotswold Road, Sutton, Surrey SM2 5NG, UK
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Publication type: Journal Article
Publication date: 2001-02-01
Journal:
Tetrahedron Letters
Quartile SCImago
Q3
Quartile WOS
Q3
SJR: 0.323
CiteScore: 3.5
Impact factor: 1.5
ISSN: 00404039, 18733581
Organic Chemistry
Drug Discovery
Biochemistry
Abstract
The efficient synthesis of a small library of 4-alkoxy-2-hydroxy-3,5,6-trifluorobenzoic acids is described via the fluoride mediated alkylation of 5,6,8-trifluoro-7-hydroxy-2-methyl-benzo[1,3]dioxin-4-one with a collection of structurally diverse bromoalkanes. The use of ion-exchange resins during the reaction sequence enabled the preparation of the majority of the products in 82–98% purity without the need for chromatography.
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Hardcastle I. R. et al. Polymer-assisted solution-phase library synthesis of 4-alkoxy-2-hydroxy-3,5,6-trifluorobenzoic acids // Tetrahedron Letters. 2001. Vol. 42. No. 7. pp. 1363-1365.
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Hardcastle I. R., Moreno Barber A., Marriott J. H., JARMAN M. Polymer-assisted solution-phase library synthesis of 4-alkoxy-2-hydroxy-3,5,6-trifluorobenzoic acids // Tetrahedron Letters. 2001. Vol. 42. No. 7. pp. 1363-1365.
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TY - JOUR
DO - 10.1016/s0040-4039(00)02252-8
UR - https://doi.org/10.1016/s0040-4039(00)02252-8
TI - Polymer-assisted solution-phase library synthesis of 4-alkoxy-2-hydroxy-3,5,6-trifluorobenzoic acids
T2 - Tetrahedron Letters
AU - Hardcastle, Ian R.
AU - Moreno Barber, Amelia
AU - Marriott, Jonathan H
AU - JARMAN, MICHAEL
PY - 2001
DA - 2001/02/01
PB - Elsevier
SP - 1363-1365
IS - 7
VL - 42
SN - 0040-4039
SN - 1873-3581
ER -
Cite this
BibTex
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@article{2001_Hardcastle,
author = {Ian R. Hardcastle and Amelia Moreno Barber and Jonathan H Marriott and MICHAEL JARMAN},
title = {Polymer-assisted solution-phase library synthesis of 4-alkoxy-2-hydroxy-3,5,6-trifluorobenzoic acids},
journal = {Tetrahedron Letters},
year = {2001},
volume = {42},
publisher = {Elsevier},
month = {feb},
url = {https://doi.org/10.1016/s0040-4039(00)02252-8},
number = {7},
pages = {1363--1365},
doi = {10.1016/s0040-4039(00)02252-8}
}
Cite this
MLA
Copy
Hardcastle, Ian R., et al. “Polymer-assisted solution-phase library synthesis of 4-alkoxy-2-hydroxy-3,5,6-trifluorobenzoic acids.” Tetrahedron Letters, vol. 42, no. 7, Feb. 2001, pp. 1363-1365. https://doi.org/10.1016/s0040-4039(00)02252-8.