Bioorganic and Medicinal Chemistry Letters

, volume 9 , issue 21 , pages 3143-3146

Piperidinylpyrroles: Design, synthesis and binding properties of novel and selective dopamine D4 receptor ligands

Christian Haubmann ¹

Harald Hübner ¹

Masha Y. Niv ¹

Hide authors affiliations Show authors affiliations: 1 affiliation

Department of Medicinal Chemistry, Emil Fischer Center, Friedrich-Alexander University, Schuhstraße 19, D-91052 Erlangen, Germany |

Publication type: Journal Article

Publication date: 1999-11-01

Elsevier

Bioorganic and Medicinal Chemistry Letters

scimago Q2

wos Q2

SJR: 0.472

CiteScore: 5.1

Impact factor: 2.2

ISSN: 0960894X, 14643405

DOI: 10.1016/s0960-894x(99)00540-5

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PubMed ID: 10560741

Organic Chemistry

Drug Discovery

Biochemistry

Molecular Biology

Pharmaceutical Science

Clinical Biochemistry

Molecular Medicine

Abstract

Piperidinylpyrroles of type 3 were synthesized through a modified Paal-Knorr reaction. For the introduction of pyrrole-substituents high yielding transformations including Sonogashira cross-coupling reactions were utilized. Employment of the reagent TosMIC gave access to the regioisomeric oxazolyl derivatives 7 and 11 which showed the highest dopamine D4 receptor binding of the series investigated.

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Haubmann C., Hübner H., Niv M. Y. Piperidinylpyrroles: Design, synthesis and binding properties of novel and selective dopamine D4 receptor ligands // Bioorganic and Medicinal Chemistry Letters. 1999. Vol. 9. No. 21. pp. 3143-3146.

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RIS |

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RIS Copy

TY - JOUR

DO - 10.1016/s0960-894x(99)00540-5

UR - https://doi.org/10.1016/s0960-894x(99)00540-5

TI - Piperidinylpyrroles: Design, synthesis and binding properties of novel and selective dopamine D4 receptor ligands

T2 - Bioorganic and Medicinal Chemistry Letters

AU - Haubmann, Christian

AU - Hübner, Harald

AU - Niv, Masha Y.

PY - 1999

DA - 1999/11/01

PB - Elsevier

SP - 3143-3146

IS - 21

VL - 9

PMID - 10560741

SN - 0960-894X

SN - 1464-3405

ER -

BibTex |

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BibTex (up to 50 authors) Copy

@article{1999_Haubmann,

author = {Christian Haubmann and Harald Hübner and Masha Y. Niv},

title = {Piperidinylpyrroles: Design, synthesis and binding properties of novel and selective dopamine D4 receptor ligands},

journal = {Bioorganic and Medicinal Chemistry Letters},

year = {1999},

volume = {9},

publisher = {Elsevier},

month = {nov},

url = {https://doi.org/10.1016/s0960-894x(99)00540-5},

number = {21},

pages = {3143--3146},

doi = {10.1016/s0960-894x(99)00540-5}

}

MLA

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MLA Copy

Haubmann, Christian, et al. “Piperidinylpyrroles: Design, synthesis and binding properties of novel and selective dopamine D4 receptor ligands.” Bioorganic and Medicinal Chemistry Letters, vol. 9, no. 21, Nov. 1999, pp. 3143-3146. https://doi.org/10.1016/s0960-894x(99)00540-5.

Publisher

Elsevier

Journal

Bioorganic and Medicinal Chemistry Letters

scimago Q2

wos Q2

SJR

0.472

CiteScore

5.1

Impact factor

2.2

ISSN

0960894X (Print)

14643405 (Electronic)