Efficient synthesis of the 18F-labelled 3-O-methyl-6-[18F]fluoro-L-DOPA
1
PET Zentrum Rossendorf, Institut für Bioanorganische und Radiopharmazeutische Chemie, Forschungszentrum Rossendorf, Postfach 510119, Dresden 01314, Germany.
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2
Institut für Interdisziplinäre Isotopenforschung, Permoserstraße 15, 04318 Leipzig, Germany
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Publication type: Journal Article
Publication date: 2003-05-12
scimago Q2
wos Q2
SJR: 0.408
CiteScore: 3.2
Impact factor: 1.8
ISSN: 09698043, 18729800
PubMed ID:
12735974
Radiation
Abstract
The 18F-labelled amino acid derivative 3-O-methyl-6-[18F]fluoro-L-DOPA ([18F]OMFD) is a potential radiotracer for imaging tumour tissue using positron emission tomography. The precursor N-formyl-3-O-methyl-4-O-boc-6-trimethyl-stannyl-L-DOPA-ethyl ester enables direct electrophilic radiofluorination by stereoselective destannylation. After partial hydrolysis, optimized HPLC purification and sterile filtration, the [18F]OMFD obtained with high radiochemical purity and ready for use. The total synthesis time is about 50 min and the radiochemical yield achieved is 20-25% (decay corrected, related to [18F]F(2)). It was demonstrated that [18F]OMFD could be produced routinely and reliably for clinical use. [18F]FDOPA-preparation devices can be used with minor modifications.
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Füchtner F., Steinbach J. Efficient synthesis of the 18F-labelled 3-O-methyl-6-[18F]fluoro-L-DOPA // Applied Radiation and Isotopes. 2003. Vol. 58. No. 5. pp. 575-578.
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Füchtner F., Steinbach J. Efficient synthesis of the 18F-labelled 3-O-methyl-6-[18F]fluoro-L-DOPA // Applied Radiation and Isotopes. 2003. Vol. 58. No. 5. pp. 575-578.
Cite this
RIS
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TY - JOUR
DO - 10.1016/s0969-8043(03)00062-9
UR - https://doi.org/10.1016/s0969-8043(03)00062-9
TI - Efficient synthesis of the 18F-labelled 3-O-methyl-6-[18F]fluoro-L-DOPA
T2 - Applied Radiation and Isotopes
AU - Füchtner, F
AU - Steinbach, J.
PY - 2003
DA - 2003/05/12
PB - Elsevier
SP - 575-578
IS - 5
VL - 58
PMID - 12735974
SN - 0969-8043
SN - 1872-9800
ER -
Cite this
BibTex (up to 50 authors)
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@article{2003_Füchtner,
author = {F Füchtner and J. Steinbach},
title = {Efficient synthesis of the 18F-labelled 3-O-methyl-6-[18F]fluoro-L-DOPA},
journal = {Applied Radiation and Isotopes},
year = {2003},
volume = {58},
publisher = {Elsevier},
month = {may},
url = {https://doi.org/10.1016/s0969-8043(03)00062-9},
number = {5},
pages = {575--578},
doi = {10.1016/s0969-8043(03)00062-9}
}
Cite this
MLA
Copy
Füchtner, F., and J. Steinbach. “Efficient synthesis of the 18F-labelled 3-O-methyl-6-[18F]fluoro-L-DOPA.” Applied Radiation and Isotopes, vol. 58, no. 5, May. 2003, pp. 575-578. https://doi.org/10.1016/s0969-8043(03)00062-9.