The ASM Study of Elastic Properties of Rat Fibroblasts, Lacking Vimentin
Publication type: Journal Article
Publication date: 2018-08-07
scimago Q2
wos Q1
SJR: 0.465
CiteScore: 1.3
Impact factor: 3.0
ISSN: 14319276, 14358115
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Abstract
First, the rat fibroblast line REF52(Vim -/-) lacking a vimentin gene, using the CRISPR system Cas9, was generated. Than we analysed the migration of REF52(Vim -/-) cells, and compared it to the migration of normal REF52 cells. The average migration rate of cells lacking vimentin does not differ from the normal cells (0.6 um/min). However, using the computer program, DiPer [5], we have found that the directional persistence of migration of the cells lacking vimentin was significantly violated (Figure 1). We assume that one of the roles of vimentin IF in the cell is the stabilizing the cellular polarity. Earlier, we demonstrated that the elastic properties of cells can play a major role in their motility [2] and could be used as a marker for metastatic potential [3].
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Vakhrusheva A. et al. The ASM Study of Elastic Properties of Rat Fibroblasts, Lacking Vimentin // Microscopy and Microanalysis. 2018. Vol. 24. No. S1. pp. 1238-1239.
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Vakhrusheva A., Zhuikov V., Endzhievskaya S., Minin A. A., Sokolova O. S. The ASM Study of Elastic Properties of Rat Fibroblasts, Lacking Vimentin // Microscopy and Microanalysis. 2018. Vol. 24. No. S1. pp. 1238-1239.
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TY - JOUR
DO - 10.1017/S1431927618006670
UR - https://doi.org/10.1017/S1431927618006670
TI - The ASM Study of Elastic Properties of Rat Fibroblasts, Lacking Vimentin
T2 - Microscopy and Microanalysis
AU - Vakhrusheva, Anna
AU - Zhuikov, Vsevolod
AU - Endzhievskaya, Sofia
AU - Minin, Alexander A.
AU - Sokolova, Olga S.
PY - 2018
DA - 2018/08/07
PB - Oxford University Press
SP - 1238-1239
IS - S1
VL - 24
SN - 1431-9276
SN - 1435-8115
ER -
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@article{2018_Vakhrusheva,
author = {Anna Vakhrusheva and Vsevolod Zhuikov and Sofia Endzhievskaya and Alexander A. Minin and Olga S. Sokolova},
title = {The ASM Study of Elastic Properties of Rat Fibroblasts, Lacking Vimentin},
journal = {Microscopy and Microanalysis},
year = {2018},
volume = {24},
publisher = {Oxford University Press},
month = {aug},
url = {https://doi.org/10.1017/S1431927618006670},
number = {S1},
pages = {1238--1239},
doi = {10.1017/S1431927618006670}
}
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Vakhrusheva, Anna, et al. “The ASM Study of Elastic Properties of Rat Fibroblasts, Lacking Vimentin.” Microscopy and Microanalysis, vol. 24, no. S1, Aug. 2018, pp. 1238-1239. https://doi.org/10.1017/S1431927618006670.