Structural Investigation of the Complex of Actin with Filamin from Entamoeba histolytica

Among different infectious diseases, the third largest cause of death has been attributed to Entamoeba histolytica. It is a protozoan that causes amoebiasis or amoebic dysentery. It is estimated that around 50 million people are affected by E .histolytica worldwide and approximately 50000-100000 deaths are registered every year, especially in developing countries [1]. Phagocytosis is the key process responsible for the pathogenesis of E. histolytica, where actin and actin-binding proteins, including filamin, play one of the key roles. Thereby, there is a necessity to understand structural interactions in the complex of actin with filamin from E. histolytica.