Insights into Actinium Complexes with Tetraacetates─AcBATA versus AcDOTA: Thermodynamic, Structural, and Labeling Properties
B. V. Egorova
1
,
Anastasia D Zubenko
2
,
Anna V. Pashanova
2, 3
,
Artem Mitrofanov
1
,
О. С. Федорова
2, 3
,
Stanislav V. Ermolaev
4
,
Aleksandr N Vasiliev
1, 4
,
A.N. Vasiliev
1, 4
,
Publication type: Journal Article
Publication date: 2023-07-28
scimago Q1
wos Q1
SJR: 0.958
CiteScore: 7.4
Impact factor: 4.7
ISSN: 00201669, 1520510X
PubMed ID:
37503892
Inorganic Chemistry
Physical and Theoretical Chemistry
Abstract
In the current research, we conducted a comparative study of the Ac3+ complex with H4DOTA and H4BATA. The stability constants of the [AcBATA]- and [AcDOTA]- complexes were studied directly by extraction methods. We discovered that the thermodynamic properties of the [AcBATA]- complex are superior to those of [AcDOTA]-. Moreover, the fast kinetics of H4BATA complexation with Ac3+ during the radiolabeling experiment was observed already at room temperature. Ac3+ was placed inside the macrocyclic cavity of the [AcBATA]- complex, preventing the release of the cation. According to DFT studies, two possible conformations were found, where two pendant arms coordinate with the metal cation on one side of the azacrown cavity and two on the other side, or three pendant arms are located on one side and one on the other. Finally, high inertness in vitro and in vivo of [AcBATA]- was discovered, making the H4BATA ligand highly preferable for application as a component of actinium-based radiopharmaceuticals.
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9
Total citations:
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Citations from 2024:
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(66%)
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Matazova E. V. et al. Insights into Actinium Complexes with Tetraacetates─AcBATA versus AcDOTA: Thermodynamic, Structural, and Labeling Properties // Inorganic Chemistry. 2023. Vol. 62. No. 31. pp. 12223-12236.
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Matazova E. V., Egorova B. V., Zubenko A. D., Zubenko A., Pashanova A. V., Mitrofanov A., Федорова О. С., Ermolaev S. V., Vasiliev A. N., Vasiliev A., Kalmykov S. N. Insights into Actinium Complexes with Tetraacetates─AcBATA versus AcDOTA: Thermodynamic, Structural, and Labeling Properties // Inorganic Chemistry. 2023. Vol. 62. No. 31. pp. 12223-12236.
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RIS
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TY - JOUR
DO - 10.1021/acs.inorgchem.3c00314
UR - https://pubs.acs.org/doi/10.1021/acs.inorgchem.3c00314
TI - Insights into Actinium Complexes with Tetraacetates─AcBATA versus AcDOTA: Thermodynamic, Structural, and Labeling Properties
T2 - Inorganic Chemistry
AU - Matazova, Ekaterina V
AU - Egorova, B. V.
AU - Zubenko, Anastasia D
AU - Zubenko, Anastasia
AU - Pashanova, Anna V.
AU - Mitrofanov, Artem
AU - Федорова, О. С.
AU - Ermolaev, Stanislav V.
AU - Vasiliev, Aleksandr N
AU - Vasiliev, A.N.
AU - Kalmykov, Stepan N.
PY - 2023
DA - 2023/07/28
PB - American Chemical Society (ACS)
SP - 12223-12236
IS - 31
VL - 62
PMID - 37503892
SN - 0020-1669
SN - 1520-510X
ER -
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BibTex (up to 50 authors)
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@article{2023_Matazova,
author = {Ekaterina V Matazova and B. V. Egorova and Anastasia D Zubenko and Anastasia Zubenko and Anna V. Pashanova and Artem Mitrofanov and О. С. Федорова and Stanislav V. Ermolaev and Aleksandr N Vasiliev and A.N. Vasiliev and Stepan N. Kalmykov},
title = {Insights into Actinium Complexes with Tetraacetates─AcBATA versus AcDOTA: Thermodynamic, Structural, and Labeling Properties},
journal = {Inorganic Chemistry},
year = {2023},
volume = {62},
publisher = {American Chemical Society (ACS)},
month = {jul},
url = {https://pubs.acs.org/doi/10.1021/acs.inorgchem.3c00314},
number = {31},
pages = {12223--12236},
doi = {10.1021/acs.inorgchem.3c00314}
}
Cite this
MLA
Copy
Matazova, Ekaterina V., et al. “Insights into Actinium Complexes with Tetraacetates─AcBATA versus AcDOTA: Thermodynamic, Structural, and Labeling Properties.” Inorganic Chemistry, vol. 62, no. 31, Jul. 2023, pp. 12223-12236. https://pubs.acs.org/doi/10.1021/acs.inorgchem.3c00314.