Journal of Medicinal Chemistry

, volume 66 , issue 1

Ligand-Based Design on the Dog-Bone-Shaped BIBR1532 Pharmacophoric Features and Synthesis of Novel Analogues as Promising Telomerase Inhibitors with In Vitro and In Vivo Evaluations

Ahmed A Al-Karmalawy ¹

Mohamed S. Nafie ²

Moataz A Shaldam ³

Ayman Abo Elmaaty ⁴

Samar A Antar ^{5, 6}

Anwar A El Hamaky ⁷

Mohamed A. Saleh ^{8, 9}

Ahmed Elkamhawy ^{10, 11}

Haytham O. Tawfik ⁷

Hide authors affiliations Show authors affiliations: 11 affiliations

Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ahram Canadian University, 6th of October City, Giza 12566, Egypt |

Chemistry Department, Faculty of Science, Suez Canal University, Ismailia 41522, Egypt |

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh 33516, Egypt |

⁴

Department of Medicinal Chemistry, Faculty of Pharmacy, Port Said University, Port Said 42526, Egypt |

⁵

Department of Pharmacology and Biochemistry, Faculty of Pharmacy, Horus University, New Damietta 34518, Egypt |

⁶

Center for Vascular and Heart Research, Fralin Biomedical Research Institute, Virginia Tech, Roanoke, Virginia 24016, United States |

⁷

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Tanta University, Tanta 31527, Egypt |

⁸

Department of Clinical Sciences, College of Medicine, University of Sharjah, Sharjah 27272, The United Arab Emirates |

⁹

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt |

¹⁰

BK21 FOUR Team and Integrated Research Institute for Drug Development, College of Pharmacy, Dongguk University-Seoul, Goyang 10326, Republic of Korea |

¹¹

Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt |

Publication type: Journal Article

Publication date: 2022-12-16

American Chemical Society (ACS)

Journal of Medicinal Chemistry

scimago Q1

wos Q1

SJR: 1.801

CiteScore: 11.5

Impact factor: 6.8

ISSN: 00222623, 15204804

DOI: 10.1021/acs.jmedchem.2c01668

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PubMed ID: 36525642

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GOST Copy

Al-Karmalawy A. A. et al. Ligand-Based Design on the Dog-Bone-Shaped BIBR1532 Pharmacophoric Features and Synthesis of Novel Analogues as Promising Telomerase Inhibitors with In Vitro and In Vivo Evaluations // Journal of Medicinal Chemistry. 2022. Vol. 66. No. 1.

GOST all authors (up to 50) Copy

Al-Karmalawy A. A., Nafie M. S., Shaldam M. A., Elmaaty A. A., Antar S. A., El Hamaky A. A., Saleh M. A., Elkamhawy A., Tawfik H. O. Ligand-Based Design on the Dog-Bone-Shaped BIBR1532 Pharmacophoric Features and Synthesis of Novel Analogues as Promising Telomerase Inhibitors with In Vitro and In Vivo Evaluations // Journal of Medicinal Chemistry. 2022. Vol. 66. No. 1.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1021/acs.jmedchem.2c01668

UR - https://doi.org/10.1021/acs.jmedchem.2c01668

TI - Ligand-Based Design on the Dog-Bone-Shaped BIBR1532 Pharmacophoric Features and Synthesis of Novel Analogues as Promising Telomerase Inhibitors with In Vitro and In Vivo Evaluations

T2 - Journal of Medicinal Chemistry

AU - Al-Karmalawy, Ahmed A

AU - Nafie, Mohamed S.

AU - Shaldam, Moataz A

AU - Elmaaty, Ayman Abo

AU - Antar, Samar A

AU - El Hamaky, Anwar A

AU - Saleh, Mohamed A.

AU - Elkamhawy, Ahmed

AU - Tawfik, Haytham O.

PY - 2022

DA - 2022/12/16

PB - American Chemical Society (ACS)

IS - 1

VL - 66

PMID - 36525642

SN - 0022-2623

SN - 1520-4804

ER -

BibTex

Cite this

BibTex (up to 50 authors) Copy

@article{2022_Al-Karmalawy,

author = {Ahmed A Al-Karmalawy and Mohamed S. Nafie and Moataz A Shaldam and Ayman Abo Elmaaty and Samar A Antar and Anwar A El Hamaky and Mohamed A. Saleh and Ahmed Elkamhawy and Haytham O. Tawfik},

title = {Ligand-Based Design on the Dog-Bone-Shaped BIBR1532 Pharmacophoric Features and Synthesis of Novel Analogues as Promising Telomerase Inhibitors with In Vitro and In Vivo Evaluations},

journal = {Journal of Medicinal Chemistry},

year = {2022},

volume = {66},

publisher = {American Chemical Society (ACS)},

month = {dec},

url = {https://doi.org/10.1021/acs.jmedchem.2c01668},

number = {1},

doi = {10.1021/acs.jmedchem.2c01668}

}

Publisher

American Chemical Society (ACS)

Journal

Journal of Medicinal Chemistry

scimago Q1

wos Q1

SJR

1.801

CiteScore

11.5

Impact factor

6.8

ISSN

00222623 (Print)

15204804 (Electronic)