Chalcone-Based Synthesis of Tetrahydropyridazines via Cloke–Wilson-Type Rearrangement-Involved Tandem Reaction between Cyclopropyl Ketones and Hydrazines
Yingfen Meng
1
,
Jiayi Gu
1
,
Meixiu Xin
1
,
Yi Jiang
1
,
Zhibo Du
2
,
Guoqing Lu
1
,
Jiayao Jiang
1
,
Albert S. Chan
1
,
Zhuofeng Ke
3
,
Yong Zou
1
2
Zhongshan WanHan Pharmceutical Company, Ltd., Zhongshan 528451, People’s Republic of China
|
Publication type: Journal Article
Publication date: 2024-02-02
scimago Q2
wos Q1
SJR: 0.737
CiteScore: 6.1
Impact factor: 3.6
ISSN: 00223263, 15206904
PubMed ID:
38307838
Organic Chemistry
Abstract
A facile and efficient approach for the synthesis of multisubstituted tetrahydropyridazines starting from cyclopropyl ketones and hydrazines has been developed. The transformation is chalcone-based and takes place via a Cloke–Wilson-type rearrangement-involved tandem reaction catalyzed by TfOH in HFIP.
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11
Total citations:
11
Citations from 2025:
8
(72.73%)
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GOST
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Meng Y. et al. Chalcone-Based Synthesis of Tetrahydropyridazines via Cloke–Wilson-Type Rearrangement-Involved Tandem Reaction between Cyclopropyl Ketones and Hydrazines // Journal of Organic Chemistry. 2024. Vol. 89. No. 4. pp. 2726-2740.
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Meng Y., Gu J., Xin M., Jiang Y., Du Z., Lu G., Jiang J., Chan A. S., Ke Z., Zou Y. Chalcone-Based Synthesis of Tetrahydropyridazines via Cloke–Wilson-Type Rearrangement-Involved Tandem Reaction between Cyclopropyl Ketones and Hydrazines // Journal of Organic Chemistry. 2024. Vol. 89. No. 4. pp. 2726-2740.
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RIS
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TY - JOUR
DO - 10.1021/acs.joc.3c02824
UR - https://pubs.acs.org/doi/10.1021/acs.joc.3c02824
TI - Chalcone-Based Synthesis of Tetrahydropyridazines via Cloke–Wilson-Type Rearrangement-Involved Tandem Reaction between Cyclopropyl Ketones and Hydrazines
T2 - Journal of Organic Chemistry
AU - Meng, Yingfen
AU - Gu, Jiayi
AU - Xin, Meixiu
AU - Jiang, Yi
AU - Du, Zhibo
AU - Lu, Guoqing
AU - Jiang, Jiayao
AU - Chan, Albert S.
AU - Ke, Zhuofeng
AU - Zou, Yong
PY - 2024
DA - 2024/02/02
PB - American Chemical Society (ACS)
SP - 2726-2740
IS - 4
VL - 89
PMID - 38307838
SN - 0022-3263
SN - 1520-6904
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2024_Meng,
author = {Yingfen Meng and Jiayi Gu and Meixiu Xin and Yi Jiang and Zhibo Du and Guoqing Lu and Jiayao Jiang and Albert S. Chan and Zhuofeng Ke and Yong Zou},
title = {Chalcone-Based Synthesis of Tetrahydropyridazines via Cloke–Wilson-Type Rearrangement-Involved Tandem Reaction between Cyclopropyl Ketones and Hydrazines},
journal = {Journal of Organic Chemistry},
year = {2024},
volume = {89},
publisher = {American Chemical Society (ACS)},
month = {feb},
url = {https://pubs.acs.org/doi/10.1021/acs.joc.3c02824},
number = {4},
pages = {2726--2740},
doi = {10.1021/acs.joc.3c02824}
}
Cite this
MLA
Copy
Meng, Yingfen, et al. “Chalcone-Based Synthesis of Tetrahydropyridazines via Cloke–Wilson-Type Rearrangement-Involved Tandem Reaction between Cyclopropyl Ketones and Hydrazines.” Journal of Organic Chemistry, vol. 89, no. 4, Feb. 2024, pp. 2726-2740. https://pubs.acs.org/doi/10.1021/acs.joc.3c02824.