Journal of Organic Chemistry, volume 84, issue 11, pages 7123-7137
Synthesis of Spiro[indole-3,5′-isoxazoles] with Anticancer Activity via a Formal [4 + 1]-Spirocyclization of Nitroalkenes to Indoles
2
Department of Chemistry and Biochemistry, Texas State University, San Marcos, Texas 78666, United States
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3
Department of Chemistry, University of Kansas, 1567 Irving Hill Road, Lawrence, Kansas 66045, United States
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Publication type: Journal Article
Publication date: 2019-05-09
Journal:
Journal of Organic Chemistry
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 3.6
ISSN: 00223263, 15206904
Organic Chemistry
Abstract
An acid-assisted [4 + 1]-cycloaddition of indoles with nitrostyrenes affords 4' H-spiro[indole-3,5'-isoxazoles] in a diastereomerically pure form. Several of these spirocyclic molecules exhibit promising anticancer activity by reducing viability and inducing differentiation of neuroblastoma cells.
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1 publication, 3.85%
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1 publication, 3.85%
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Citations by publishers
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1
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7
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Multidisciplinary Digital Publishing Institute (MDPI)
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7 publications, 26.92%
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Elsevier
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6 publications, 23.08%
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4 publications, 15.38%
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3 publications, 11.54%
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Wiley
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2 publications, 7.69%
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Bentham Science
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2 publications, 7.69%
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Springer Nature
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Springer Nature
1 publication, 3.85%
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Thieme
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Thieme
1 publication, 3.85%
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Aksenov A. et al. Synthesis of Spiro[indole-3,5′-isoxazoles] with Anticancer Activity via a Formal [4 + 1]-Spirocyclization of Nitroalkenes to Indoles // Journal of Organic Chemistry. 2019. Vol. 84. No. 11. pp. 7123-7137.
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Aksenov A., Aksenov D. A., Arutiunov N. A., Aksenov N. A., Aleksandrova E. V., Zhao Z., Du L., Kornienko A., Rubin M. Synthesis of Spiro[indole-3,5′-isoxazoles] with Anticancer Activity via a Formal [4 + 1]-Spirocyclization of Nitroalkenes to Indoles // Journal of Organic Chemistry. 2019. Vol. 84. No. 11. pp. 7123-7137.
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TY - JOUR
DO - 10.1021/acs.joc.9b00808
UR - https://doi.org/10.1021%2Facs.joc.9b00808
TI - Synthesis of Spiro[indole-3,5′-isoxazoles] with Anticancer Activity via a Formal [4 + 1]-Spirocyclization of Nitroalkenes to Indoles
T2 - Journal of Organic Chemistry
AU - Aleksandrova, Elena V
AU - Aksenov, Alexander V.
AU - Rubin, Michael
AU - Aksenov, Dmitrii A
AU - Arutiunov, Nikolai A
AU - Aksenov, Nicolai A.
AU - Zhao, Z.
AU - Du, Liqin
AU - Kornienko, Alexander
PY - 2019
DA - 2019/05/09 00:00:00
PB - American Chemical Society (ACS)
SP - 7123-7137
IS - 11
VL - 84
SN - 0022-3263
SN - 1520-6904
ER -
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@article{2019_Aksenov,
author = {Elena V Aleksandrova and Alexander V. Aksenov and Michael Rubin and Dmitrii A Aksenov and Nikolai A Arutiunov and Nicolai A. Aksenov and Z. Zhao and Liqin Du and Alexander Kornienko},
title = {Synthesis of Spiro[indole-3,5′-isoxazoles] with Anticancer Activity via a Formal [4 + 1]-Spirocyclization of Nitroalkenes to Indoles},
journal = {Journal of Organic Chemistry},
year = {2019},
volume = {84},
publisher = {American Chemical Society (ACS)},
month = {may},
url = {https://doi.org/10.1021%2Facs.joc.9b00808},
number = {11},
pages = {7123--7137},
doi = {10.1021/acs.joc.9b00808}
}
Cite this
MLA
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Aksenov, Alexander V., et al. “Synthesis of Spiro[indole-3,5′-isoxazoles] with Anticancer Activity via a Formal [4 + 1]-Spirocyclization of Nitroalkenes to Indoles.” Journal of Organic Chemistry, vol. 84, no. 11, May. 2019, pp. 7123-7137. https://doi.org/10.1021%2Facs.joc.9b00808.