Synthesis of Spiro[indole-3,5′-isoxazoles] with Anticancer Activity via a Formal [4 + 1]-Spirocyclization of Nitroalkenes to Indoles
Publication type: Journal Article
Publication date: 2019-05-09
scimago Q2
wos Q1
SJR: 0.737
CiteScore: 6.1
Impact factor: 3.6
ISSN: 00223263, 15206904
PubMed ID:
31070030
Organic Chemistry
Abstract
An acid-assisted [4 + 1]-cycloaddition of indoles with nitrostyrenes affords 4' H-spiro[indole-3,5'-isoxazoles] in a diastereomerically pure form. Several of these spirocyclic molecules exhibit promising anticancer activity by reducing viability and inducing differentiation of neuroblastoma cells.
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35
Total citations:
35
Citations from 2024:
10
(28%)
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GOST
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Aksenov A. et al. Synthesis of Spiro[indole-3,5′-isoxazoles] with Anticancer Activity via a Formal [4 + 1]-Spirocyclization of Nitroalkenes to Indoles // Journal of Organic Chemistry. 2019. Vol. 84. No. 11. pp. 7123-7137.
GOST all authors (up to 50)
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Aksenov A., Aksenov D. A., Arutiunov N. A., Aksenov N. A., Aleksandrova E. V., Zhao Z., Du L., Kornienko A., Rubin M. Synthesis of Spiro[indole-3,5′-isoxazoles] with Anticancer Activity via a Formal [4 + 1]-Spirocyclization of Nitroalkenes to Indoles // Journal of Organic Chemistry. 2019. Vol. 84. No. 11. pp. 7123-7137.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1021/acs.joc.9b00808
UR - https://doi.org/10.1021/acs.joc.9b00808
TI - Synthesis of Spiro[indole-3,5′-isoxazoles] with Anticancer Activity via a Formal [4 + 1]-Spirocyclization of Nitroalkenes to Indoles
T2 - Journal of Organic Chemistry
AU - Aksenov, Alexander V.
AU - Aksenov, Dmitrii A
AU - Arutiunov, Nikolai A
AU - Aksenov, Nicolai A.
AU - Aleksandrova, Elena V
AU - Zhao, Z.
AU - Du, Liqin
AU - Kornienko, Alexander
AU - Rubin, Michael
PY - 2019
DA - 2019/05/09
PB - American Chemical Society (ACS)
SP - 7123-7137
IS - 11
VL - 84
PMID - 31070030
SN - 0022-3263
SN - 1520-6904
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2019_Aksenov,
author = {Alexander V. Aksenov and Dmitrii A Aksenov and Nikolai A Arutiunov and Nicolai A. Aksenov and Elena V Aleksandrova and Z. Zhao and Liqin Du and Alexander Kornienko and Michael Rubin},
title = {Synthesis of Spiro[indole-3,5′-isoxazoles] with Anticancer Activity via a Formal [4 + 1]-Spirocyclization of Nitroalkenes to Indoles},
journal = {Journal of Organic Chemistry},
year = {2019},
volume = {84},
publisher = {American Chemical Society (ACS)},
month = {may},
url = {https://doi.org/10.1021/acs.joc.9b00808},
number = {11},
pages = {7123--7137},
doi = {10.1021/acs.joc.9b00808}
}
Cite this
MLA
Copy
Aksenov, Alexander V., et al. “Synthesis of Spiro[indole-3,5′-isoxazoles] with Anticancer Activity via a Formal [4 + 1]-Spirocyclization of Nitroalkenes to Indoles.” Journal of Organic Chemistry, vol. 84, no. 11, May. 2019, pp. 7123-7137. https://doi.org/10.1021/acs.joc.9b00808.