Organic Process Research and Development

Scalable Synthesis of C5aR1 Antagonist ACT-1014-6470 via N⁷-Selective Reductive Amination of an Unprotected Pyrazole Starting Material and Intramolecular Urea Formation with 1,1′-Carbonyl-di(1,2,4-triazol) (CDT)

Stefan Reber ¹

Nicole Blumer ¹

Daniel Leuenberger ¹

Tony Fleischer ¹

Dorte Renneberg ¹

Stefan Abele ¹

Gabriel Schäfer ¹

Chemistry Process R&D, Idorsia Pharmaceuticals Ltd., Hegenheimermattweg 91, CH-4123 Allschwil, Switzerland |

Publication type: Journal Article

Publication date: 2024-02-08

American Chemical Society (ACS)

Journal: Organic Process Research and Development

scimago Q1

SJR: 0.900

CiteScore: 6.9

Impact factor: 3.1

ISSN: 10836160, 1520586X

DOI: 10.1021/acs.oprd.3c00492

Copy DOI

Organic Chemistry

Physical and Theoretical Chemistry

Create a profile to get free access to personal recommendations for colleagues and new articles.

Metrics

Cite this

GOST | RIS | BibTex

Found error?

Publisher

American Chemical Society (ACS)

Journal

scimago Q1

SJR

0.900

CiteScore

6.9

Impact factor

3.1

ISSN

10836160 (Print)

1520586X (Electronic)

Scalable Synthesis of C5aR1 Antagonist ACT-1014-6470 via N7-Selective Reductive Amination of an Unprotected Pyrazole Starting Material and Intramolecular Urea Formation with 1,1′-Carbonyl-di(1,2,4-triazol) (CDT)