Asymmetric Fluorination Approach to the Scalable Synthesis of a SYK Inhibitor
Тип публикации: Journal Article
Дата публикации: 2015-06-25
scimago Q1
wos Q1
БС1
SJR: 0.865
CiteScore: 5.4
Impact factor: 3.5
ISSN: 10836160, 1520586X
Organic Chemistry
Physical and Theoretical Chemistry
Краткое описание
A large-scale process for the synthesis of SYK inhibitor 1 has been developed and used to deliver multi-kilogram yields of this active pharmaceutical ingredient. Integral to the scalable process is a combined chiral auxiliary and chiral catalyst mediated diastereoselective fluorination. Safe processes for BH3·DMS-mediated reduction of ester and amide functions and azide introduction, and a robust Suzuki–Miyaura coupling of a pyrazyl boronate with chloronapthyridine, are described.
Найдено
Ничего не найдено, попробуйте изменить настройки фильтра.
Найдено
Ничего не найдено, попробуйте изменить настройки фильтра.
Топ-30
Журналы
|
1
2
3
4
5
6
7
|
|
|
Organic Process Research and Development
7 публикаций, 30.43%
|
|
|
Chemical Communications
2 публикации, 8.7%
|
|
|
Chinese Chemical Letters
1 публикация, 4.35%
|
|
|
Chinese Journal of Chemistry
1 публикация, 4.35%
|
|
|
European Journal of Organic Chemistry
1 публикация, 4.35%
|
|
|
Chemistry - A European Journal
1 публикация, 4.35%
|
|
|
Chemical Reviews
1 публикация, 4.35%
|
|
|
Organic Letters
1 публикация, 4.35%
|
|
|
Green Chemistry
1 публикация, 4.35%
|
|
|
Organic and Biomolecular Chemistry
1 публикация, 4.35%
|
|
|
Journal of Organic Chemistry
1 публикация, 4.35%
|
|
|
Organic Chemistry Frontiers
1 публикация, 4.35%
|
|
|
Advances in Heterocyclic Chemistry
1 публикация, 4.35%
|
|
|
1
2
3
4
5
6
7
|
Издатели
|
2
4
6
8
10
|
|
|
American Chemical Society (ACS)
10 публикаций, 43.48%
|
|
|
Royal Society of Chemistry (RSC)
5 публикаций, 21.74%
|
|
|
Wiley
4 публикации, 17.39%
|
|
|
Elsevier
3 публикации, 13.04%
|
|
|
2
4
6
8
10
|
- Мы не учитываем публикации, у которых нет DOI.
- Статистика публикаций обновляется еженедельно.
Вы ученый?
Создайте профиль, чтобы получать персональные рекомендации коллег, конференций и новых статей.
Метрики
23
Всего цитирований:
23
Цитирований c 2024:
3
(13.05%)
Цитировать
ГОСТ |
RIS |
BibTex |
MLA
Цитировать
ГОСТ
Скопировать
Curtis N. R. et al. Asymmetric Fluorination Approach to the Scalable Synthesis of a SYK Inhibitor // Organic Process Research and Development. 2015. Vol. 19. No. 7. pp. 865-871.
ГОСТ со всеми авторами (до 50)
Скопировать
Curtis N. R., Davies S. H., Gray M., Leach S. G., Mckie R. A., Vernon L. E., Walkington A. J. Asymmetric Fluorination Approach to the Scalable Synthesis of a SYK Inhibitor // Organic Process Research and Development. 2015. Vol. 19. No. 7. pp. 865-871.
Цитировать
RIS
Скопировать
TY - JOUR
DO - 10.1021/acs.oprd.5b00131
UR - https://doi.org/10.1021/acs.oprd.5b00131
TI - Asymmetric Fluorination Approach to the Scalable Synthesis of a SYK Inhibitor
T2 - Organic Process Research and Development
AU - Curtis, Neil R
AU - Davies, Suzanne H
AU - Gray, Matthew
AU - Leach, Stuart G
AU - Mckie, Ross A
AU - Vernon, Lois E
AU - Walkington, Andrew J.
PY - 2015
DA - 2015/06/25
PB - American Chemical Society (ACS)
SP - 865-871
IS - 7
VL - 19
SN - 1083-6160
SN - 1520-586X
ER -
Цитировать
BibTex (до 50 авторов)
Скопировать
@article{2015_Curtis,
author = {Neil R Curtis and Suzanne H Davies and Matthew Gray and Stuart G Leach and Ross A Mckie and Lois E Vernon and Andrew J. Walkington},
title = {Asymmetric Fluorination Approach to the Scalable Synthesis of a SYK Inhibitor},
journal = {Organic Process Research and Development},
year = {2015},
volume = {19},
publisher = {American Chemical Society (ACS)},
month = {jun},
url = {https://doi.org/10.1021/acs.oprd.5b00131},
number = {7},
pages = {865--871},
doi = {10.1021/acs.oprd.5b00131}
}
Цитировать
MLA
Скопировать
Curtis, Neil R., et al. “Asymmetric Fluorination Approach to the Scalable Synthesis of a SYK Inhibitor.” Organic Process Research and Development, vol. 19, no. 7, Jun. 2015, pp. 865-871. https://doi.org/10.1021/acs.oprd.5b00131.