Development of the Asymmetric Hydrogenation Step for Multikilogram Production of Etamicastat
1
Laboratory of Chemistry, Department of Research & Development, BIAL, 4745-457 S. Mamede do Coronado, Portugal
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Publication type: Journal Article
Publication date: 2016-03-28
scimago Q1
wos Q1
SJR: 0.865
CiteScore: 5.4
Impact factor: 3.5
ISSN: 10836160, 1520586X
Organic Chemistry
Physical and Theoretical Chemistry
Abstract
The asymmetric hydrogenation of methyl (6,8-difluoro-2H-chromen-3-yl)carbamate is a key step in the manufacturing route to etamicastat. A development of this step including the ruthenium or rhodium catalyst screening and the influence of the catalyst preparation (isolated, preformed in solution or in situ), solvent, temperature, pressure, additive, and concentration on the performance of the given ligand was discussed. Scale-up experiments for the best catalysts under optimized conditions were described.
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15
Total citations:
15
Citations from 2024:
3
(20%)
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GOST
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Beliaev A. Development of the Asymmetric Hydrogenation Step for Multikilogram Production of Etamicastat // Organic Process Research and Development. 2016. Vol. 20. No. 4. pp. 724-732.
GOST all authors (up to 50)
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Beliaev A. Development of the Asymmetric Hydrogenation Step for Multikilogram Production of Etamicastat // Organic Process Research and Development. 2016. Vol. 20. No. 4. pp. 724-732.
Cite this
RIS
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TY - JOUR
DO - 10.1021/acs.oprd.6b00041
UR - https://doi.org/10.1021/acs.oprd.6b00041
TI - Development of the Asymmetric Hydrogenation Step for Multikilogram Production of Etamicastat
T2 - Organic Process Research and Development
AU - Beliaev, Alexandre
PY - 2016
DA - 2016/03/28
PB - American Chemical Society (ACS)
SP - 724-732
IS - 4
VL - 20
SN - 1083-6160
SN - 1520-586X
ER -
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BibTex (up to 50 authors)
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@article{2016_Beliaev,
author = {Alexandre Beliaev},
title = {Development of the Asymmetric Hydrogenation Step for Multikilogram Production of Etamicastat},
journal = {Organic Process Research and Development},
year = {2016},
volume = {20},
publisher = {American Chemical Society (ACS)},
month = {mar},
url = {https://doi.org/10.1021/acs.oprd.6b00041},
number = {4},
pages = {724--732},
doi = {10.1021/acs.oprd.6b00041}
}
Cite this
MLA
Copy
Beliaev, Alexandre. “Development of the Asymmetric Hydrogenation Step for Multikilogram Production of Etamicastat.” Organic Process Research and Development, vol. 20, no. 4, Mar. 2016, pp. 724-732. https://doi.org/10.1021/acs.oprd.6b00041.