Modeling and Design of a Flow-Microreactor-Based Process for Synthesizing Ionic Liquids
Yuichi Nakahara
1, 2
,
Bert Metten
3
,
Osamu Tonomura
2, 4
,
Aiichiro Nagaki
2, 5
,
Shinji Hasebe
2, 4
,
J. Yoshida
2, 6
1
New Frontiers Research Group, Frontier Research Laboratories, Institute For Innovation, Ajinomoto Co., Inc., 1-1 Suzuki-cho, Kawasaki-ku, Kawasaki, Kanagawa 210-8681, Japan
|
3
Ajinomoto Bio Pharma Services, Cooppallaan 91, B-9230 Wetteren, Belgium
|
6
National Institute of Technology, Suzuka College, Shiroko-cho, Suzuka, Mie 510-0294, Japan
|
Publication type: Journal Article
Publication date: 2019-01-31
scimago Q1
wos Q1
SJR: 0.865
CiteScore: 5.4
Impact factor: 3.5
ISSN: 10836160, 1520586X
Organic Chemistry
Physical and Theoretical Chemistry
Abstract
A synthesis process for the ionic liquid (IL) 1-butyl-3-methylimidazolium chloride (BMIM.Cl) was developed using a flow microreactor (FMR) in this study. After the reaction rate analysis, the FMR was efficiently designed using computational fluid dynamics simulation, which can shorten the process development time by reducing trial-and-error experimentation. The designed FMR is composed of a V-shaped mixer and a tubular reactor having a millimeter-scale inner diameter. From the viewpoint of process operation and control, reactors with larger inner diameter are basically preferable. The influence of three inner diameters, 0.75, 2.16, and 4.35 mm, that satisfy temperature constraints on product quality, product yield, and production volume was investigated. It was found that as the inner diameter becomes large, the product yield becomes low because the mass transfer approaches the rate-limiting step of the reaction process. To avoid this problem, it was proposed that static mixers should be built in the reac...
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Nakahara Y. et al. Modeling and Design of a Flow-Microreactor-Based Process for Synthesizing Ionic Liquids // Organic Process Research and Development. 2019. Vol. 23. No. 4. pp. 641-647.
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Nakahara Y., Metten B., Tonomura O., Nagaki A., Hasebe S., Yoshida J. Modeling and Design of a Flow-Microreactor-Based Process for Synthesizing Ionic Liquids // Organic Process Research and Development. 2019. Vol. 23. No. 4. pp. 641-647.
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TY - JOUR
DO - 10.1021/acs.oprd.8b00436
UR - https://doi.org/10.1021/acs.oprd.8b00436
TI - Modeling and Design of a Flow-Microreactor-Based Process for Synthesizing Ionic Liquids
T2 - Organic Process Research and Development
AU - Nakahara, Yuichi
AU - Metten, Bert
AU - Tonomura, Osamu
AU - Nagaki, Aiichiro
AU - Hasebe, Shinji
AU - Yoshida, J.
PY - 2019
DA - 2019/01/31
PB - American Chemical Society (ACS)
SP - 641-647
IS - 4
VL - 23
SN - 1083-6160
SN - 1520-586X
ER -
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@article{2019_Nakahara,
author = {Yuichi Nakahara and Bert Metten and Osamu Tonomura and Aiichiro Nagaki and Shinji Hasebe and J. Yoshida},
title = {Modeling and Design of a Flow-Microreactor-Based Process for Synthesizing Ionic Liquids},
journal = {Organic Process Research and Development},
year = {2019},
volume = {23},
publisher = {American Chemical Society (ACS)},
month = {jan},
url = {https://doi.org/10.1021/acs.oprd.8b00436},
number = {4},
pages = {641--647},
doi = {10.1021/acs.oprd.8b00436}
}
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MLA
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Nakahara, Yuichi, et al. “Modeling and Design of a Flow-Microreactor-Based Process for Synthesizing Ionic Liquids.” Organic Process Research and Development, vol. 23, no. 4, Jan. 2019, pp. 641-647. https://doi.org/10.1021/acs.oprd.8b00436.