Palladium-Catalyzed Isoquinoline Synthesis by Tandem C–H Allylation and Oxidative Cyclization of Benzylamines with Allyl Acetate
Publication type: Journal Article
Publication date: 2021-05-17
scimago Q1
wos Q1
SJR: 1.235
CiteScore: 8.7
Impact factor: 5.0
ISSN: 15237060, 15237052
PubMed ID:
33999646
Organic Chemistry
Biochemistry
Physical and Theoretical Chemistry
Abstract
A novel approach to synthesize 3-methylisoquinolines via a one-pot, two-step, palladium(II)-catalyzed tandem C-H allylation/intermolecular amination and aromatization is reported. A wide series of 3-methylisoquinoline derivatives were obtained directly using this method in moderate to good yields, and we highlight the synthetic importance of this new transformation.
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Total citations:
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Citations from 2025:
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(14.29%)
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Chen Y. et al. Palladium-Catalyzed Isoquinoline Synthesis by Tandem C–H Allylation and Oxidative Cyclization of Benzylamines with Allyl Acetate // Organic Letters. 2021. Vol. 23. No. 11. pp. 4209-4213.
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Chen Y., Huang Z., Dai C., Yang S., Shi D., Zhao Y. Palladium-Catalyzed Isoquinoline Synthesis by Tandem C–H Allylation and Oxidative Cyclization of Benzylamines with Allyl Acetate // Organic Letters. 2021. Vol. 23. No. 11. pp. 4209-4213.
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TY - JOUR
DO - 10.1021/acs.orglett.1c01153
UR - https://doi.org/10.1021/acs.orglett.1c01153
TI - Palladium-Catalyzed Isoquinoline Synthesis by Tandem C–H Allylation and Oxidative Cyclization of Benzylamines with Allyl Acetate
T2 - Organic Letters
AU - Chen, Yujie
AU - Huang, Zhibin
AU - Dai, Chenyang
AU - Yang, Shan
AU - Shi, Daqing
AU - Zhao, Yingsheng
PY - 2021
DA - 2021/05/17
PB - American Chemical Society (ACS)
SP - 4209-4213
IS - 11
VL - 23
PMID - 33999646
SN - 1523-7060
SN - 1523-7052
ER -
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BibTex (up to 50 authors)
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@article{2021_Chen,
author = {Yujie Chen and Zhibin Huang and Chenyang Dai and Shan Yang and Daqing Shi and Yingsheng Zhao},
title = {Palladium-Catalyzed Isoquinoline Synthesis by Tandem C–H Allylation and Oxidative Cyclization of Benzylamines with Allyl Acetate},
journal = {Organic Letters},
year = {2021},
volume = {23},
publisher = {American Chemical Society (ACS)},
month = {may},
url = {https://doi.org/10.1021/acs.orglett.1c01153},
number = {11},
pages = {4209--4213},
doi = {10.1021/acs.orglett.1c01153}
}
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MLA
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Chen, Yujie, et al. “Palladium-Catalyzed Isoquinoline Synthesis by Tandem C–H Allylation and Oxidative Cyclization of Benzylamines with Allyl Acetate.” Organic Letters, vol. 23, no. 11, May. 2021, pp. 4209-4213. https://doi.org/10.1021/acs.orglett.1c01153.