Synthesis and Structural Characterization of 2′-Deoxy-2′-fluoro-l -uridine Nucleic Acids
Publication type: Journal Article
Publication date: 2021-06-18
scimago Q1
wos Q1
SJR: 1.235
CiteScore: 8.7
Impact factor: 5.0
ISSN: 15237060, 15237052
PubMed ID:
34142829
Organic Chemistry
Biochemistry
Physical and Theoretical Chemistry
Abstract
Despite the development of artificial l-RNA/DNA as therapeutic molecules, the in-depth investigation on their chemical modifications is still limited. Here, we synthesize a chemically derivatized 2'-deoxy-2'-fluoro-l-uridine building block and incorporate it into oligonucleotides. Our thermo-denaturization and enzymatic digestion experiments reveal their superior stability. Furthermore, one crystal structure of l-type fluoro-DNA is determined to characterize its handedness. Our results reveal the increase of l-helix stability by fluoro-modification and provide the foundation for its future functional application.
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13
Total citations:
13
Citations from 2024:
5
(38%)
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GOST
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Dantsu Y., Zhang Y., Zhang W. Synthesis and Structural Characterization of 2′-Deoxy-2′-fluoro-l-uridine Nucleic Acids // Organic Letters. 2021. Vol. 23. No. 13. pp. 5007-5011.
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Dantsu Y., Zhang Y., Zhang W. Synthesis and Structural Characterization of 2′-Deoxy-2′-fluoro-l-uridine Nucleic Acids // Organic Letters. 2021. Vol. 23. No. 13. pp. 5007-5011.
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RIS
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TY - JOUR
DO - 10.1021/acs.orglett.1c01498
UR - https://doi.org/10.1021/acs.orglett.1c01498
TI - Synthesis and Structural Characterization of 2′-Deoxy-2′-fluoro-l-uridine Nucleic Acids
T2 - Organic Letters
AU - Dantsu, Yuliya
AU - Zhang, Ying
AU - Zhang, Wen
PY - 2021
DA - 2021/06/18
PB - American Chemical Society (ACS)
SP - 5007-5011
IS - 13
VL - 23
PMID - 34142829
SN - 1523-7060
SN - 1523-7052
ER -
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BibTex (up to 50 authors)
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@article{2021_Dantsu,
author = {Yuliya Dantsu and Ying Zhang and Wen Zhang},
title = {Synthesis and Structural Characterization of 2′-Deoxy-2′-fluoro-l-uridine Nucleic Acids},
journal = {Organic Letters},
year = {2021},
volume = {23},
publisher = {American Chemical Society (ACS)},
month = {jun},
url = {https://doi.org/10.1021/acs.orglett.1c01498},
number = {13},
pages = {5007--5011},
doi = {10.1021/acs.orglett.1c01498}
}
Cite this
MLA
Copy
Dantsu, Yuliya, et al. “Synthesis and Structural Characterization of 2′-Deoxy-2′-fluoro-l-uridine Nucleic Acids.” Organic Letters, vol. 23, no. 13, Jun. 2021, pp. 5007-5011. https://doi.org/10.1021/acs.orglett.1c01498.