Ketenimines as Intermediates To Access Difluoromethoxylated Scaffolds
1
Publication type: Journal Article
Publication date: 2022-11-07
scimago Q1
wos Q1
SJR: 1.235
CiteScore: 8.7
Impact factor: 5.0
ISSN: 15237060, 15237052
PubMed ID:
36342749
Abstract
We report herein the in situ generation of difluoromethoxylated ketenimines. This novel intermediate is readily obtained from the corresponding oxime through a Beckmann rearrangement. The reactivity potential of this species is demonstrated as it easily undergoes addition of various nucleophiles, with a great modularity of the starting oxime. The broad applicability of this transformation leads to a chemical library of original molecules bearing -OCHF2, an Emergent Fluorinated Group (EFG).
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Total citations:
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Citations from 2025:
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(66.67%)
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Loison A. et al. Ketenimines as Intermediates To Access Difluoromethoxylated Scaffolds // Organic Letters. 2022. Vol. 24. No. 45.
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Loison A., Hanquet G., Toulgoat F., Billard T., Panossian A., Leroux F. Ketenimines as Intermediates To Access Difluoromethoxylated Scaffolds // Organic Letters. 2022. Vol. 24. No. 45.
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TY - JOUR
DO - 10.1021/acs.orglett.2c03283
UR - https://doi.org/10.1021/acs.orglett.2c03283
TI - Ketenimines as Intermediates To Access Difluoromethoxylated Scaffolds
T2 - Organic Letters
AU - Loison, Anaïs
AU - Hanquet, Gilles
AU - Toulgoat, F.
AU - Billard, Thierry
AU - Panossian, Armen
AU - Leroux, Frédéric
PY - 2022
DA - 2022/11/07
PB - American Chemical Society (ACS)
IS - 45
VL - 24
PMID - 36342749
SN - 1523-7060
SN - 1523-7052
ER -
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BibTex (up to 50 authors)
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@article{2022_Loison,
author = {Anaïs Loison and Gilles Hanquet and F. Toulgoat and Thierry Billard and Armen Panossian and Frédéric Leroux},
title = {Ketenimines as Intermediates To Access Difluoromethoxylated Scaffolds},
journal = {Organic Letters},
year = {2022},
volume = {24},
publisher = {American Chemical Society (ACS)},
month = {nov},
url = {https://doi.org/10.1021/acs.orglett.2c03283},
number = {45},
doi = {10.1021/acs.orglett.2c03283}
}