Brønsted Acid–Lewis Acid (BA–LA) Induced Final Deprotection/Peptide Resin Cleavage in Fmoc/t-Bu Solid-Phase Peptide Synthesis: HCl/FeCl3 and AcOH/FeCl3 as Viable PFAS-Free Alternatives for TFA
Тип публикации: Journal Article
Дата публикации: 2024-07-29
SCImago Q1
Tоп 10% SCImago
WOS Q1
БС1
SJR: 1.007
CiteScore: 7.7
Impact factor: 4.7
ISSN: 15237060, 15237052
PubMed ID:
39073347
Краткое описание
The widely used Fmoc/t-Bu solid-phase peptide synthesis (SPPS) is hampered by relying on corrosive, per/polyfluoroalkyl substance (PFAS) classified trifluoroacetic acid (TFA) as a universal protecting group (PG) removal/resin cleavage reagent. We report that suitable combinations of Brønsted acids (BAs) and Lewis acids (LAs) such as HCl/FeCl3 and AcOH/FeCl3 constitute viable alternatives for TFA as PFAS-free cleavage agents. Using water miscible dimethyl carbonate (DMC) and acetonitrile (MeCN) as solvents enabled diluting cleavage mixtures with suitable aqueous solutions, allowing for direct use in purification in which removal of >99.99% iron from an HCl/FeCl3 induced cleavage was demonstrated.
Найдено
Ничего не найдено, попробуйте изменить настройки фильтра.
Для доступа к списку цитирований публикации необходимо авторизоваться.
Топ-30
Журналы
|
1
2
3
|
|
|
Organic Letters
3 публикации, 21.43%
|
|
|
Organic Process Research and Development
3 публикации, 21.43%
|
|
|
ChemSusChem
1 публикация, 7.14%
|
|
|
Bioconjugate Chemistry
1 публикация, 7.14%
|
|
|
Results in Chemistry
1 публикация, 7.14%
|
|
|
Journal of Organic Chemistry
1 публикация, 7.14%
|
|
|
Green Chemistry
1 публикация, 7.14%
|
|
|
Molecules
1 публикация, 7.14%
|
|
|
ACS Sustainable Chemistry and Engineering
1 публикация, 7.14%
|
|
|
ACS Omega
1 публикация, 7.14%
|
|
|
1
2
3
|
Издатели
|
2
4
6
8
10
|
|
|
American Chemical Society (ACS)
10 публикаций, 71.43%
|
|
|
Wiley
1 публикация, 7.14%
|
|
|
Elsevier
1 публикация, 7.14%
|
|
|
Royal Society of Chemistry (RSC)
1 публикация, 7.14%
|
|
|
MDPI
1 публикация, 7.14%
|
|
|
2
4
6
8
10
|
- Мы не учитываем публикации, у которых нет DOI.
- Статистика публикаций обновляется еженедельно.
Вы ученый?
Создайте профиль, чтобы получать персональные рекомендации коллег, конференций и новых статей.
Войти с ORCID
Метрики
14
Всего цитирований:
14
Цитирований c 2025:
14
(100%)
Цитировать
ГОСТ |
RIS |
BibTex |
MLA
Цитировать
ГОСТ
Скопировать
Pawlas J. et al. Brønsted Acid–Lewis Acid (BA–LA) Induced Final Deprotection/Peptide Resin Cleavage in Fmoc/t-Bu Solid-Phase Peptide Synthesis: HCl/FeCl3 and AcOH/FeCl3 as Viable PFAS-Free Alternatives for TFA // Organic Letters. 2024. Vol. 26. No. 31. pp. 6787-6791.
ГОСТ со всеми авторами (до 50)
Скопировать
Pawlas J., André C., Rasmussen J. H., Ludemann-Hombourger O. Brønsted Acid–Lewis Acid (BA–LA) Induced Final Deprotection/Peptide Resin Cleavage in Fmoc/t-Bu Solid-Phase Peptide Synthesis: HCl/FeCl3 and AcOH/FeCl3 as Viable PFAS-Free Alternatives for TFA // Organic Letters. 2024. Vol. 26. No. 31. pp. 6787-6791.
Цитировать
RIS
Скопировать
TY - JOUR
DO - 10.1021/acs.orglett.4c02569
UR - https://pubs.acs.org/doi/10.1021/acs.orglett.4c02569
TI - Brønsted Acid–Lewis Acid (BA–LA) Induced Final Deprotection/Peptide Resin Cleavage in Fmoc/t-Bu Solid-Phase Peptide Synthesis: HCl/FeCl3 and AcOH/FeCl3 as Viable PFAS-Free Alternatives for TFA
T2 - Organic Letters
AU - Pawlas, Jan
AU - André, Christophe
AU - Rasmussen, Jon H
AU - Ludemann-Hombourger, Olivier
PY - 2024
DA - 2024/07/29
PB - American Chemical Society (ACS)
SP - 6787-6791
IS - 31
VL - 26
PMID - 39073347
SN - 1523-7060
SN - 1523-7052
ER -
Цитировать
BibTex (до 50 авторов)
Скопировать
@article{2024_Pawlas,
author = {Jan Pawlas and Christophe André and Jon H Rasmussen and Olivier Ludemann-Hombourger},
title = {Brønsted Acid–Lewis Acid (BA–LA) Induced Final Deprotection/Peptide Resin Cleavage in Fmoc/t-Bu Solid-Phase Peptide Synthesis: HCl/FeCl3 and AcOH/FeCl3 as Viable PFAS-Free Alternatives for TFA},
journal = {Organic Letters},
year = {2024},
volume = {26},
publisher = {American Chemical Society (ACS)},
month = {jul},
url = {https://pubs.acs.org/doi/10.1021/acs.orglett.4c02569},
number = {31},
pages = {6787--6791},
doi = {10.1021/acs.orglett.4c02569}
}
Цитировать
MLA
Скопировать
Pawlas, Jan, et al. “Brønsted Acid–Lewis Acid (BA–LA) Induced Final Deprotection/Peptide Resin Cleavage in Fmoc/t-Bu Solid-Phase Peptide Synthesis: HCl/FeCl3 and AcOH/FeCl3 as Viable PFAS-Free Alternatives for TFA.” Organic Letters, vol. 26, no. 31, Jul. 2024, pp. 6787-6791. https://pubs.acs.org/doi/10.1021/acs.orglett.4c02569.
Ошибка в публикации?