American Chemical Society (ACS)
Organic Letters
,  том 27 ,  издание 1 ,  страницы 46-50

Palladium-Catalyzed N-Allylic Alkylation of Pyrazoles and Unactivated Vinylcyclopropanes

Тип публикации: Journal Article
Дата публикации: 2024-12-20
American Chemical Society (ACS)
scimago Q1
wos Q1
БС1
SJR: 1.235
CiteScore: 8.7
Impact factor: 5.0
ISSN: 15237060, 15237052
Краткое описание
An efficient palladium-catalyzed N-allylic alkylation of pyrazoles and unactivated vinylcyclopropanes is demonstrated, affording various N-alkyl pyrazoles in ≤99% yield. This protocol displays high atom economy, a broad range of substrates, and excellent regioselectivity and stereoselectivity. Late-stage modification of bioactive molecules, scaled-up reaction, and divergent derivatization documented the practicability of this methodology. The preliminary mechanistic investigation hinted that the Pd–H species promotes the ring opening of cyclopropanes.
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Organic Letters
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European Journal of Organic Chemistry
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Cheng S. et al. Palladium-Catalyzed N-Allylic Alkylation of Pyrazoles and Unactivated Vinylcyclopropanes // Organic Letters. 2024. Vol. 27. No. 1. pp. 46-50.
ГОСТ со всеми авторами (до 50) Скопировать
Cheng S., Zhang X., Yang Z., Wang A., Ye Z. S. Palladium-Catalyzed N-Allylic Alkylation of Pyrazoles and Unactivated Vinylcyclopropanes // Organic Letters. 2024. Vol. 27. No. 1. pp. 46-50.
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TY - JOUR
DO - 10.1021/acs.orglett.4c03808
UR - https://pubs.acs.org/doi/10.1021/acs.orglett.4c03808
TI - Palladium-Catalyzed N-Allylic Alkylation of Pyrazoles and Unactivated Vinylcyclopropanes
T2 - Organic Letters
AU - Cheng, Shao-Jie
AU - Zhang, Xin-Li
AU - Yang, Zhen-Xu
AU - Wang, Ai-Hua
AU - Ye, Zhi Shi
PY - 2024
DA - 2024/12/20
PB - American Chemical Society (ACS)
SP - 46-50
IS - 1
VL - 27
PMID - 39704564
SN - 1523-7060
SN - 1523-7052
ER -
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@article{2024_Cheng,
author = {Shao-Jie Cheng and Xin-Li Zhang and Zhen-Xu Yang and Ai-Hua Wang and Zhi Shi Ye},
title = {Palladium-Catalyzed N-Allylic Alkylation of Pyrazoles and Unactivated Vinylcyclopropanes},
journal = {Organic Letters},
year = {2024},
volume = {27},
publisher = {American Chemical Society (ACS)},
month = {dec},
url = {https://pubs.acs.org/doi/10.1021/acs.orglett.4c03808},
number = {1},
pages = {46--50},
doi = {10.1021/acs.orglett.4c03808}
}
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Cheng, Shao-Jie, et al. “Palladium-Catalyzed N-Allylic Alkylation of Pyrazoles and Unactivated Vinylcyclopropanes.” Organic Letters, vol. 27, no. 1, Dec. 2024, pp. 46-50. https://pubs.acs.org/doi/10.1021/acs.orglett.4c03808.