Diastereoselective Synthesis of Cyclobutanes via Rh-Catalyzed Unprecedented C–C Bond Cleavage of Alkylidenecyclopropanes
Taeeun Kim
1, 2, 3, 4, 5
,
T.-e. Kim
4, 5
,
Taejoo Jeong
1, 2, 3, 4, 5
,
Eunjae Chung
1, 2, 3, 4, 5
,
Pargat Singh
1, 2, 3, 4, 5
,
Amitava Rakshit
1, 2, 3, 4, 5
,
Jihye Park
1, 2, 3, 4, 5
,
Ji-Hye Park
4, 5
,
In Su Kim
1, 2, 3, 4, 5
2
School of Pharmacy
4
School of Pharmacy, Suwon, Republic of Korea
|
Publication type: Journal Article
Publication date: 2025-01-23
scimago Q1
wos Q1
SJR: 1.235
CiteScore: 8.7
Impact factor: 5.0
ISSN: 15237060, 15237052
Abstract
The stereoselective synthesis of highly substituted cyclobutanes is essential for the development of lead candidates in drug discovery. Herein, we present a novel Rh(III)-catalyzed reaction pathway for synthesizing substituted cyclobutanes, which involves a concerted N-C bond formation and C-C bond cleavage between 2-aryl quinazolinones and alkylidenecyclopropanes. Notably, the combination of Rh(III) catalyst and HFIP solvent plays a critical role in facilitating the formation of cyclobutane rings.
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Journal of Organic Chemistry
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American Chemical Society (ACS)
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2
Total citations:
2
Citations from 2024:
2
(100%)
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GOST
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Kim T. et al. Diastereoselective Synthesis of Cyclobutanes via Rh-Catalyzed Unprecedented C–C Bond Cleavage of Alkylidenecyclopropanes // Organic Letters. 2025. Vol. 27. No. 5. pp. 1226-1231.
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Kim T., Kim T., Jeong T., Chung E., Singh P., Rakshit A., Park J., Park J., Kim I. S. Diastereoselective Synthesis of Cyclobutanes via Rh-Catalyzed Unprecedented C–C Bond Cleavage of Alkylidenecyclopropanes // Organic Letters. 2025. Vol. 27. No. 5. pp. 1226-1231.
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TY - JOUR
DO - 10.1021/acs.orglett.4c04779
UR - https://pubs.acs.org/doi/10.1021/acs.orglett.4c04779
TI - Diastereoselective Synthesis of Cyclobutanes via Rh-Catalyzed Unprecedented C–C Bond Cleavage of Alkylidenecyclopropanes
T2 - Organic Letters
AU - Kim, Taeeun
AU - Kim, T.-e.
AU - Jeong, Taejoo
AU - Chung, Eunjae
AU - Singh, Pargat
AU - Rakshit, Amitava
AU - Park, Jihye
AU - Park, Ji-Hye
AU - Kim, In Su
PY - 2025
DA - 2025/01/23
PB - American Chemical Society (ACS)
SP - 1226-1231
IS - 5
VL - 27
SN - 1523-7060
SN - 1523-7052
ER -
Cite this
BibTex (up to 50 authors)
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@article{2025_Kim,
author = {Taeeun Kim and T.-e. Kim and Taejoo Jeong and Eunjae Chung and Pargat Singh and Amitava Rakshit and Jihye Park and Ji-Hye Park and In Su Kim},
title = {Diastereoselective Synthesis of Cyclobutanes via Rh-Catalyzed Unprecedented C–C Bond Cleavage of Alkylidenecyclopropanes},
journal = {Organic Letters},
year = {2025},
volume = {27},
publisher = {American Chemical Society (ACS)},
month = {jan},
url = {https://pubs.acs.org/doi/10.1021/acs.orglett.4c04779},
number = {5},
pages = {1226--1231},
doi = {10.1021/acs.orglett.4c04779}
}
Cite this
MLA
Copy
Kim, Taeeun, et al. “Diastereoselective Synthesis of Cyclobutanes via Rh-Catalyzed Unprecedented C–C Bond Cleavage of Alkylidenecyclopropanes.” Organic Letters, vol. 27, no. 5, Jan. 2025, pp. 1226-1231. https://pubs.acs.org/doi/10.1021/acs.orglett.4c04779.
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