American Chemical Society (ACS)
Organic Letters
,  том 27 ,  издание 29 ,  страницы 7822-7826

Sappanumols A–C, Three Homoisoflavonoids with Antiinflammatory Activities from Sappan lignum

Qiqi Wang 1, 2
, 
Haojie Liu 3, 4
, 
GUO-QING QIN 1, 2
, 
Hong Chen 5, 6
, 
J.-L. Lin 1, 2
, 
Ping Yang 1, 2
, 
Yue Shen 1, 2
, 
Kewu Zeng 1, 2
, 
Qing-Ying Zhang 1, 2
, 
Pengfei Tu 1, 2
1
 
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Beijing, China | 
2
 
3
 
Biology Institute, Jinan, China | 
4
 
5
 
School of Chinese Materia Medica, Beijing, China | 
6
 
Тип публикации: Journal Article
Дата публикации: 2025-07-14
American Chemical Society (ACS)
scimago Q1
wos Q1
БС1
SJR: 1.235
CiteScore: 8.7
Impact factor: 5.0
ISSN: 15237060, 15237052
Краткое описание
Sappanumols A-C (1-3, respectively), three unprecedented homoisoflavonoids, were isolated from Sappan lignum. Their structures were elucidated by comprehensive spectroscopic analysis and ECD computation methods. Compound 3 demonstrated inhibitory effects on LPS-induced NO production in BV-2 cells with an IC50 value of 16.99 μM. Compound 3 decreased the levels of TNF-α and IL-6 in a dose-dependent manner and exhibited significant anti-inflammatory activity in a zebrafish inflammation model.
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Wang Q. et al. Sappanumols A–C, Three Homoisoflavonoids with Antiinflammatory Activities from Sappan lignum // Organic Letters. 2025. Vol. 27. No. 29. pp. 7822-7826.
ГОСТ со всеми авторами (до 50) Скопировать
Wang Q., Liu H., QIN G., Chen H., Lin J., Yang P., Shen Y., Zeng K., Zhang Q., Tu P. Sappanumols A–C, Three Homoisoflavonoids with Antiinflammatory Activities from Sappan lignum // Organic Letters. 2025. Vol. 27. No. 29. pp. 7822-7826.
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TY - JOUR
DO - 10.1021/acs.orglett.5c02020
UR - https://pubs.acs.org/doi/10.1021/acs.orglett.5c02020
TI - Sappanumols A–C, Three Homoisoflavonoids with Antiinflammatory Activities from Sappan lignum
T2 - Organic Letters
AU - Wang, Qiqi
AU - Liu, Haojie
AU - QIN, GUO-QING
AU - Chen, Hong
AU - Lin, J.-L.
AU - Yang, Ping
AU - Shen, Yue
AU - Zeng, Kewu
AU - Zhang, Qing-Ying
AU - Tu, Pengfei
PY - 2025
DA - 2025/07/14
PB - American Chemical Society (ACS)
SP - 7822-7826
IS - 29
VL - 27
SN - 1523-7060
SN - 1523-7052
ER -
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@article{2025_Wang,
author = {Qiqi Wang and Haojie Liu and GUO-QING QIN and Hong Chen and J.-L. Lin and Ping Yang and Yue Shen and Kewu Zeng and Qing-Ying Zhang and Pengfei Tu},
title = {Sappanumols A–C, Three Homoisoflavonoids with Antiinflammatory Activities from Sappan lignum},
journal = {Organic Letters},
year = {2025},
volume = {27},
publisher = {American Chemical Society (ACS)},
month = {jul},
url = {https://pubs.acs.org/doi/10.1021/acs.orglett.5c02020},
number = {29},
pages = {7822--7826},
doi = {10.1021/acs.orglett.5c02020}
}
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Wang, Qiqi, et al. “Sappanumols A–C, Three Homoisoflavonoids with Antiinflammatory Activities from Sappan lignum.” Organic Letters, vol. 27, no. 29, Jul. 2025, pp. 7822-7826. https://pubs.acs.org/doi/10.1021/acs.orglett.5c02020.