American Chemical Society (ACS)
Organic Letters
,  volume 27 ,  issue 34 ,  pages 9542-9546

Palladium-Catalyzed Late-Stage Maleimidation of Phenylalanine-Containing Peptides

Jian Tang 1, 2
, 
Yi Sun 1, 2
, 
Qi Lu 1, 2
, 
Fengjie Lu 1, 2
, 
Shina Yan 1, 2
, 
Fengyan Ma 1, 2
1
 
Key Laboratory of Catalytic Conversion and Clean Energy in Universities of Shandong Province, School of Chemistry and Chemical Engineering, Qufu, P. R. China | 
2
 
Publication type: Journal Article
Publication date: 2025-08-20
American Chemical Society (ACS)
scimago Q1
wos Q1
SJR: 1.235
CiteScore: 8.7
Impact factor: 5.0
ISSN: 15237060, 15237052
Abstract
The incorporation of bioactive fragments or non-natural covalent linkages has shown to significantly improve the chemical stability and biological activity of peptides. In this study, we have developed a novel methodology for site-selective Pd-catalyzed maleimidation of phenylalanine-containing peptides. This synthetic strategy offers a straightforward and efficient approach for the construction of maleimide-phenylalanine covalent peptide conjugates. The merit of this method includes broad substrate tolerance, exclusive formation of Heck-type products, and excellent chemoselectivity.
Found 
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Tang J. et al. Palladium-Catalyzed Late-Stage Maleimidation of Phenylalanine-Containing Peptides // Organic Letters. 2025. Vol. 27. No. 34. pp. 9542-9546.
GOST all authors (up to 50) Copy
Tang J., Sun Y., Lu Q., Lu F., Yan S., Ma F. Palladium-Catalyzed Late-Stage Maleimidation of Phenylalanine-Containing Peptides // Organic Letters. 2025. Vol. 27. No. 34. pp. 9542-9546.
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RIS Copy
TY - JOUR
DO - 10.1021/acs.orglett.5c03081
UR - https://pubs.acs.org/doi/10.1021/acs.orglett.5c03081
TI - Palladium-Catalyzed Late-Stage Maleimidation of Phenylalanine-Containing Peptides
T2 - Organic Letters
AU - Tang, Jian
AU - Sun, Yi
AU - Lu, Qi
AU - Lu, Fengjie
AU - Yan, Shina
AU - Ma, Fengyan
PY - 2025
DA - 2025/08/20
PB - American Chemical Society (ACS)
SP - 9542-9546
IS - 34
VL - 27
SN - 1523-7060
SN - 1523-7052
ER -
BibTex |
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BibTex (up to 50 authors) Copy
@article{2025_Tang,
author = {Jian Tang and Yi Sun and Qi Lu and Fengjie Lu and Shina Yan and Fengyan Ma},
title = {Palladium-Catalyzed Late-Stage Maleimidation of Phenylalanine-Containing Peptides},
journal = {Organic Letters},
year = {2025},
volume = {27},
publisher = {American Chemical Society (ACS)},
month = {aug},
url = {https://pubs.acs.org/doi/10.1021/acs.orglett.5c03081},
number = {34},
pages = {9542--9546},
doi = {10.1021/acs.orglett.5c03081}
}
MLA
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MLA Copy
Tang, Jian, et al. “Palladium-Catalyzed Late-Stage Maleimidation of Phenylalanine-Containing Peptides.” Organic Letters, vol. 27, no. 34, Aug. 2025, pp. 9542-9546. https://pubs.acs.org/doi/10.1021/acs.orglett.5c03081.