Synthesis of Chiral Azabicycles from Pyroglutaminols
Chulho Choi
1
,
Philippe Nuhant
1
,
James J. Mousseau
1
,
Xiaojing Yang
1
,
Brian S Gerstenberger
2
,
Jessica M. Williams
3
,
Stephen W Wright
1
1
Medicinal Chemistry, Medicine Design, Pfizer WorldWide R&D, 445 Eastern Point Road, Groton, Connecticut 06340, United States
|
2
Medicinal Chemistry, Medicine Design, Pfizer WorldWide R&D, 610 Main Street, Cambridge, Massachusetts 02139, United States
|
Publication type: Journal Article
Publication date: 2016-10-27
scimago Q1
wos Q1
SJR: 1.235
CiteScore: 8.7
Impact factor: 5.0
ISSN: 15237060, 15237052
PubMed ID:
27786487
Organic Chemistry
Biochemistry
Physical and Theoretical Chemistry
Abstract
The stereocontrolled synthesis of a range of substituted bicyclic morpholine and piperazine derivatives is reported from substituted pyroglutaminols via an intramolecular SN2 cyclization as the key step. This enantiospecific approach toward chiral bicyclic morpholines and piperazines offers new opportunities to access these challenging ring systems, which are becoming increasingly common motifs in drug discovery.
Found
Nothing found, try to update filter.
Found
Nothing found, try to update filter.
Top-30
Journals
|
1
2
|
|
|
Organic Process Research and Development
2 publications, 18.18%
|
|
|
Organic Letters
2 publications, 18.18%
|
|
|
Acta Crystallographica Section E: Crystallographic Communications
1 publication, 9.09%
|
|
|
Chinese Journal of Organic Chemistry
1 publication, 9.09%
|
|
|
Helvetica Chimica Acta
1 publication, 9.09%
|
|
|
European Journal of Organic Chemistry
1 publication, 9.09%
|
|
|
ChemistrySelect
1 publication, 9.09%
|
|
|
Chemical Communications
1 publication, 9.09%
|
|
|
Synthesis
1 publication, 9.09%
|
|
|
1
2
|
Publishers
|
1
2
3
4
|
|
|
American Chemical Society (ACS)
4 publications, 36.36%
|
|
|
Wiley
3 publications, 27.27%
|
|
|
International Union of Crystallography (IUCr)
1 publication, 9.09%
|
|
|
Shanghai Institute of Organic Chemistry
1 publication, 9.09%
|
|
|
Royal Society of Chemistry (RSC)
1 publication, 9.09%
|
|
|
Georg Thieme Verlag KG
1 publication, 9.09%
|
|
|
1
2
3
4
|
- We do not take into account publications without a DOI.
- Statistics recalculated weekly.
Are you a researcher?
Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
11
Total citations:
11
Citations from 2024:
0
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Choi C. et al. Synthesis of Chiral Azabicycles from Pyroglutaminols // Organic Letters. 2016. Vol. 18. No. 21. pp. 5748-5751.
GOST all authors (up to 50)
Copy
Choi C., Nuhant P., Mousseau J. J., Yang X., Gerstenberger B. S., Williams J. M., Wright S. W. Synthesis of Chiral Azabicycles from Pyroglutaminols // Organic Letters. 2016. Vol. 18. No. 21. pp. 5748-5751.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1021/acs.orglett.6b03024
UR - https://doi.org/10.1021/acs.orglett.6b03024
TI - Synthesis of Chiral Azabicycles from Pyroglutaminols
T2 - Organic Letters
AU - Choi, Chulho
AU - Nuhant, Philippe
AU - Mousseau, James J.
AU - Yang, Xiaojing
AU - Gerstenberger, Brian S
AU - Williams, Jessica M.
AU - Wright, Stephen W
PY - 2016
DA - 2016/10/27
PB - American Chemical Society (ACS)
SP - 5748-5751
IS - 21
VL - 18
PMID - 27786487
SN - 1523-7060
SN - 1523-7052
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2016_Choi,
author = {Chulho Choi and Philippe Nuhant and James J. Mousseau and Xiaojing Yang and Brian S Gerstenberger and Jessica M. Williams and Stephen W Wright},
title = {Synthesis of Chiral Azabicycles from Pyroglutaminols},
journal = {Organic Letters},
year = {2016},
volume = {18},
publisher = {American Chemical Society (ACS)},
month = {oct},
url = {https://doi.org/10.1021/acs.orglett.6b03024},
number = {21},
pages = {5748--5751},
doi = {10.1021/acs.orglett.6b03024}
}
Cite this
MLA
Copy
Choi, Chulho, et al. “Synthesis of Chiral Azabicycles from Pyroglutaminols.” Organic Letters, vol. 18, no. 21, Oct. 2016, pp. 5748-5751. https://doi.org/10.1021/acs.orglett.6b03024.