Transition-Metal-Free Decarboxylation of 3,3,3-Trifluoro-2,2-dimethylpropanoic Acid for the Preparation of C(CF3)Me2-Containing Heteroarenes
Publication type: Journal Article
Publication date: 2018-08-27
scimago Q1
wos Q1
SJR: 1.235
CiteScore: 8.7
Impact factor: 5.0
ISSN: 15237060, 15237052
PubMed ID:
30148368
Organic Chemistry
Biochemistry
Physical and Theoretical Chemistry
Abstract
The direct synthesis of C(CF3)Me2-substituted heteroarenes by decarboxylative 1,1-dimethyltrifluoroethylation of heteroarenes with 3,3,3-trifluoro-2,2-dimethylpropanoic acid is reported. This method does not need the transition-metal catalyst, and the base is crucial for this reaction. A series of previously unknown C(CF3)Me2-containing heteroarenes were obtained in high yields and have potential applications in the drug discovery process.
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Total citations:
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Citations from 2025:
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GOST
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Liu S. et al. Transition-Metal-Free Decarboxylation of 3,3,3-Trifluoro-2,2-dimethylpropanoic Acid for the Preparation of C(CF3)Me2-Containing Heteroarenes // Organic Letters. 2018. Vol. 20. No. 17. pp. 5497-5501.
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Liu S., Huang Y., Qing F., Xu X. H. Transition-Metal-Free Decarboxylation of 3,3,3-Trifluoro-2,2-dimethylpropanoic Acid for the Preparation of C(CF3)Me2-Containing Heteroarenes // Organic Letters. 2018. Vol. 20. No. 17. pp. 5497-5501.
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RIS
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TY - JOUR
DO - 10.1021/acs.orglett.8b02451
UR - https://doi.org/10.1021/acs.orglett.8b02451
TI - Transition-Metal-Free Decarboxylation of 3,3,3-Trifluoro-2,2-dimethylpropanoic Acid for the Preparation of C(CF3)Me2-Containing Heteroarenes
T2 - Organic Letters
AU - Liu, Shuai
AU - Huang, Yangen
AU - Qing, Fengling
AU - Xu, Xiu Hua
PY - 2018
DA - 2018/08/27
PB - American Chemical Society (ACS)
SP - 5497-5501
IS - 17
VL - 20
PMID - 30148368
SN - 1523-7060
SN - 1523-7052
ER -
Cite this
BibTex (up to 50 authors)
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@article{2018_Liu,
author = {Shuai Liu and Yangen Huang and Fengling Qing and Xiu Hua Xu},
title = {Transition-Metal-Free Decarboxylation of 3,3,3-Trifluoro-2,2-dimethylpropanoic Acid for the Preparation of C(CF3)Me2-Containing Heteroarenes},
journal = {Organic Letters},
year = {2018},
volume = {20},
publisher = {American Chemical Society (ACS)},
month = {aug},
url = {https://doi.org/10.1021/acs.orglett.8b02451},
number = {17},
pages = {5497--5501},
doi = {10.1021/acs.orglett.8b02451}
}
Cite this
MLA
Copy
Liu, Shuai, et al. “Transition-Metal-Free Decarboxylation of 3,3,3-Trifluoro-2,2-dimethylpropanoic Acid for the Preparation of C(CF3)Me2-Containing Heteroarenes.” Organic Letters, vol. 20, no. 17, Aug. 2018, pp. 5497-5501. https://doi.org/10.1021/acs.orglett.8b02451.