BACE1 Aptamer-Modified Tetrahedral Framework Nucleic Acid to Treat Alzheimer’s Disease in an APP-PS1 Animal Model
Publication type: Journal Article
Publication date: 2022-09-23
scimago Q1
wos Q1
SJR: 1.921
CiteScore: 14.5
Impact factor: 8.2
ISSN: 19448244, 19448252
PubMed ID:
36149663
General Materials Science
Abstract
Alzheimer's disease is a neurodegenerative disease caused by excessive amyloid β protein-induced neurotoxicity. However, drugs targeting amyloid β protein production face many problems, such as the low utilization rate of drugs by cells and the difficulty of drugs in penetrating the blood-brain barrier. A tetrahedral framework nucleic acid is a new type of nanonucleic acid structure that functions as a therapy and drug carrier. Here, we synthesized a BACE1 aptamer-modified tetrahedral framework nucleic acid and tested its therapeutic effect on Alzheimer's disease in vitro and in vivo. Our results demonstrated that the tetrahedral framework nucleic acid could be used as a carrier to deliver the BACE1 aptamer to the brain to reduce the production of amyloid β proteins. It also played an antiapoptotic role by reducing the production of reactive oxygen species. Thus, this nanomaterial is a potential drug for Alzheimer's disease.
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18
Total citations:
18
Citations from 2024:
11
(61.11%)
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GOST
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Wang Y. et al. BACE1 Aptamer-Modified Tetrahedral Framework Nucleic Acid to Treat Alzheimer’s Disease in an APP-PS1 Animal Model // ACS applied materials & interfaces. 2022. Vol. 14. No. 39. pp. 44228-44238.
GOST all authors (up to 50)
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Wang Y., Zhu J., Jia W., Xiong H., Qiu W., Xu R., Lin Y. BACE1 Aptamer-Modified Tetrahedral Framework Nucleic Acid to Treat Alzheimer’s Disease in an APP-PS1 Animal Model // ACS applied materials & interfaces. 2022. Vol. 14. No. 39. pp. 44228-44238.
Cite this
RIS
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TY - JOUR
DO - 10.1021/acsami.2c14626
UR - https://doi.org/10.1021/acsami.2c14626
TI - BACE1 Aptamer-Modified Tetrahedral Framework Nucleic Acid to Treat Alzheimer’s Disease in an APP-PS1 Animal Model
T2 - ACS applied materials & interfaces
AU - Wang, Yangyang
AU - Zhu, Jianwei
AU - Jia, Weiqiang
AU - Xiong, Huan
AU - Qiu, Wenqiao
AU - Xu, Ruxiang
AU - Lin, Yunfeng
PY - 2022
DA - 2022/09/23
PB - American Chemical Society (ACS)
SP - 44228-44238
IS - 39
VL - 14
PMID - 36149663
SN - 1944-8244
SN - 1944-8252
ER -
Cite this
BibTex (up to 50 authors)
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@article{2022_Wang,
author = {Yangyang Wang and Jianwei Zhu and Weiqiang Jia and Huan Xiong and Wenqiao Qiu and Ruxiang Xu and Yunfeng Lin},
title = {BACE1 Aptamer-Modified Tetrahedral Framework Nucleic Acid to Treat Alzheimer’s Disease in an APP-PS1 Animal Model},
journal = {ACS applied materials & interfaces},
year = {2022},
volume = {14},
publisher = {American Chemical Society (ACS)},
month = {sep},
url = {https://doi.org/10.1021/acsami.2c14626},
number = {39},
pages = {44228--44238},
doi = {10.1021/acsami.2c14626}
}
Cite this
MLA
Copy
Wang, Yangyang, et al. “BACE1 Aptamer-Modified Tetrahedral Framework Nucleic Acid to Treat Alzheimer’s Disease in an APP-PS1 Animal Model.” ACS applied materials & interfaces, vol. 14, no. 39, Sep. 2022, pp. 44228-44238. https://doi.org/10.1021/acsami.2c14626.