Detection of the Prostate Cancer Biomarker PCA3 with Electrochemical and Impedance-Based Biosensors
Osvaldo NOVAIS DE Oliveira
1, 2
,
Andrey Soares
1, 2
,
Valquiria C. Rodrigues
1
,
Matias Eliseo Melendez
3
,
Alexandre Cesar Santos
3
,
Eliney Ferreira Faria
3
,
Rui M. Reis
3, 4, 5
,
André Lopes Carvalho
3
,
2
National Laboratory of Nanotechnology for Agribusiness (LNNA), Embrapa Instrumentation, 13560-970 São Carlos, Brazil
|
3
Molecular Oncology Research Center, Barretos Cancer Hospital, 14784-400 Barretos, Brazil
|
5
ICVS/3B’s - PT Government Associate Laboratory, Braga/guimarães, Portugal
|
Publication type: Journal Article
Publication date: 2019-11-25
scimago Q1
wos Q1
SJR: 1.921
CiteScore: 14.5
Impact factor: 8.2
ISSN: 19448244, 19448252
PubMed ID:
31765118
General Materials Science
Abstract
Diagnosis of prostate cancer via PCA3 biomarker detection is promising to be much more efficient than with the prostatic specific antigens currently used. In this study, we present the first electrochemical and impedance-based biosensors that are capable of detecting PCA3 down to 0.128 nmol/L. The biosensors were made with a layer of PCA3-complementary single-stranded DNA (ssDNA) probe, immobilized on a layer-by-layer (LbL) film of chitosan (CHT) and carbon nanotubes (MWCNT). They are highly selective to PCA3, which was confirmed in impedance measurements and with polarization-modulated infrared reflection absorption spectroscopy (PM-IRRAS). Using information visualization methods, we could also distinguish between cell lines expressing the endogenous PCA3 long noncoding RNA (lncRNA) from cells that did not contain detectable levels of this biomarker. Since the methods involved in fabrication the biosensors are potentially low cost, one may hope to deploy PCA3 tests in any laboratory of clinical analyses and even for point-of-care diagnostics.
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Total citations:
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Citations from 2024:
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GOST
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DE Oliveira O. N. et al. Detection of the Prostate Cancer Biomarker PCA3 with Electrochemical and Impedance-Based Biosensors // ACS applied materials & interfaces. 2019. Vol. 11. No. 50. pp. 46645-46650.
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DE Oliveira O. N., Soares A., Rodrigues V. C., Melendez M. E., Santos A. C., Faria E. F., Reis R. M., Carvalho A. L., Oliveira O. N. Detection of the Prostate Cancer Biomarker PCA3 with Electrochemical and Impedance-Based Biosensors // ACS applied materials & interfaces. 2019. Vol. 11. No. 50. pp. 46645-46650.
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RIS
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TY - JOUR
DO - 10.1021/acsami.9b19180
UR - https://doi.org/10.1021/acsami.9b19180
TI - Detection of the Prostate Cancer Biomarker PCA3 with Electrochemical and Impedance-Based Biosensors
T2 - ACS applied materials & interfaces
AU - DE Oliveira, Osvaldo NOVAIS
AU - Soares, Andrey
AU - Rodrigues, Valquiria C.
AU - Melendez, Matias Eliseo
AU - Santos, Alexandre Cesar
AU - Faria, Eliney Ferreira
AU - Reis, Rui M.
AU - Carvalho, André Lopes
AU - Oliveira, Osvaldo N.
PY - 2019
DA - 2019/11/25
PB - American Chemical Society (ACS)
SP - 46645-46650
IS - 50
VL - 11
PMID - 31765118
SN - 1944-8244
SN - 1944-8252
ER -
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@article{2019_DE Oliveira,
author = {Osvaldo NOVAIS DE Oliveira and Andrey Soares and Valquiria C. Rodrigues and Matias Eliseo Melendez and Alexandre Cesar Santos and Eliney Ferreira Faria and Rui M. Reis and André Lopes Carvalho and Osvaldo N. Oliveira},
title = {Detection of the Prostate Cancer Biomarker PCA3 with Electrochemical and Impedance-Based Biosensors},
journal = {ACS applied materials & interfaces},
year = {2019},
volume = {11},
publisher = {American Chemical Society (ACS)},
month = {nov},
url = {https://doi.org/10.1021/acsami.9b19180},
number = {50},
pages = {46645--46650},
doi = {10.1021/acsami.9b19180}
}
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DE Oliveira, Osvaldo NOVAIS, et al. “Detection of the Prostate Cancer Biomarker PCA3 with Electrochemical and Impedance-Based Biosensors.” ACS applied materials & interfaces, vol. 11, no. 50, Nov. 2019, pp. 46645-46650. https://doi.org/10.1021/acsami.9b19180.