ACS Combinatorial Science, volume 20, issue 6, pages 335-343

Polycyclic Sulfoximines as New Scaffolds for Drug Discovery

Mark L G Borst 1
, 
Cécile M J Ouairy 1
, 
Sander C Fokkema 1
, 
Alessandro Cecchi 1
, 
Jessica M C A Kerckhoffs 1
, 
Vincent L De Boer 1
, 
Peter J Van Den Boogaard 1
, 
Rutger F Bus 1
, 
Rijko Ebens 1
, 
Rob Van Der Hulst 1
, 
Joop Knol 1
, 
Rob Libbers 1
, 
Zhou M Lion 1
, 
Bart W Settels 1
, 
Ellen De Wever 1
, 
Khaled A Attia 1
, 
Piet-Jan Sinnema 1
, 
Jesse M. de Gooijer 1
, 
Karen Harkema 1
, 
Marieke Hazewinkel 1
, 
Susan Snijder 1
, 
Kees L Pouwer 1
Show full list: 22 authors
1
 
Syncom B.V., Kadijk 3, 9747 AT Groningen, The Netherlands | 
Publication type: Journal Article
Publication date: 2018-05-01
scimago Q1
SJR: 0.833
CiteScore: —
Impact factor: —
ISSN: 21568952, 21568944
General Chemistry
General Medicine
Abstract
The design and synthesis of three novel polycyclic scaffolds containing sulfoximines are presented in this work, which exemplify that sulfoximines represent a real opportunity for the discovery of new drug candidates. Additionally, the structures present at least two points of diversification and contain a high level of sp3-character, hence being very interesting 3D scaffolds. The compounds synthesized were added to the compound collection of the European Lead Factory.
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