Polycyclic Sulfoximines as New Scaffolds for Drug Discovery
Mark L G Borst
1
,
Cécile M J Ouairy
1
,
Sander C Fokkema
1
,
Alessandro Cecchi
1
,
Jessica M C A Kerckhoffs
1
,
Vincent L De Boer
1
,
Peter J Van Den Boogaard
1
,
Rutger F Bus
1
,
Rijko Ebens
1
,
Rob Van Der Hulst
1
,
Joop Knol
1
,
Rob Libbers
1
,
Zhou M Lion
1
,
Bart W Settels
1
,
Ellen De Wever
1
,
Khaled A Attia
1
,
Piet-Jan Sinnema
1
,
Jesse M. de Gooijer
1
,
Karen Harkema
1
,
Marieke Hazewinkel
1
,
Susan Snijder
1
,
Kees L Pouwer
1
1
Syncom B.V., Kadijk 3, 9747 AT Groningen, The Netherlands
|
Publication type: Journal Article
Publication date: 2018-05-01
SJR: —
CiteScore: —
Impact factor: —
ISSN: 21568952, 21568944
PubMed ID:
29714998
General Chemistry
General Medicine
Abstract
The design and synthesis of three novel polycyclic scaffolds containing sulfoximines are presented in this work, which exemplify that sulfoximines represent a real opportunity for the discovery of new drug candidates. Additionally, the structures present at least two points of diversification and contain a high level of sp3-character, hence being very interesting 3D scaffolds. The compounds synthesized were added to the compound collection of the European Lead Factory.
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Metrics
29
Total citations:
29
Citations from 2024:
8
(27.58%)
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GOST
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Borst M. L. G. et al. Polycyclic Sulfoximines as New Scaffolds for Drug Discovery // ACS Combinatorial Science. 2018. Vol. 20. No. 6. pp. 335-343.
GOST all authors (up to 50)
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Borst M. L. G., Ouairy C. M. J., Fokkema S. C., Cecchi A., Kerckhoffs J. M. C. A., De Boer V. L., Van Den Boogaard P. J., Bus R. F., Ebens R., Van Der Hulst R., Knol J., Libbers R., Lion Z. M., Settels B. W., De Wever E., Attia K. A., Sinnema P., de Gooijer J. M., Harkema K., Hazewinkel M., Snijder S., Pouwer K. L. Polycyclic Sulfoximines as New Scaffolds for Drug Discovery // ACS Combinatorial Science. 2018. Vol. 20. No. 6. pp. 335-343.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1021/acscombsci.7b00150
UR - https://doi.org/10.1021/acscombsci.7b00150
TI - Polycyclic Sulfoximines as New Scaffolds for Drug Discovery
T2 - ACS Combinatorial Science
AU - Borst, Mark L G
AU - Ouairy, Cécile M J
AU - Fokkema, Sander C
AU - Cecchi, Alessandro
AU - Kerckhoffs, Jessica M C A
AU - De Boer, Vincent L
AU - Van Den Boogaard, Peter J
AU - Bus, Rutger F
AU - Ebens, Rijko
AU - Van Der Hulst, Rob
AU - Knol, Joop
AU - Libbers, Rob
AU - Lion, Zhou M
AU - Settels, Bart W
AU - De Wever, Ellen
AU - Attia, Khaled A
AU - Sinnema, Piet-Jan
AU - de Gooijer, Jesse M.
AU - Harkema, Karen
AU - Hazewinkel, Marieke
AU - Snijder, Susan
AU - Pouwer, Kees L
PY - 2018
DA - 2018/05/01
PB - American Chemical Society (ACS)
SP - 335-343
IS - 6
VL - 20
PMID - 29714998
SN - 2156-8952
SN - 2156-8944
ER -
Cite this
BibTex (up to 50 authors)
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@article{2018_Borst,
author = {Mark L G Borst and Cécile M J Ouairy and Sander C Fokkema and Alessandro Cecchi and Jessica M C A Kerckhoffs and Vincent L De Boer and Peter J Van Den Boogaard and Rutger F Bus and Rijko Ebens and Rob Van Der Hulst and Joop Knol and Rob Libbers and Zhou M Lion and Bart W Settels and Ellen De Wever and Khaled A Attia and Piet-Jan Sinnema and Jesse M. de Gooijer and Karen Harkema and Marieke Hazewinkel and Susan Snijder and Kees L Pouwer},
title = {Polycyclic Sulfoximines as New Scaffolds for Drug Discovery},
journal = {ACS Combinatorial Science},
year = {2018},
volume = {20},
publisher = {American Chemical Society (ACS)},
month = {may},
url = {https://doi.org/10.1021/acscombsci.7b00150},
number = {6},
pages = {335--343},
doi = {10.1021/acscombsci.7b00150}
}
Cite this
MLA
Copy
Borst, Mark L. G., et al. “Polycyclic Sulfoximines as New Scaffolds for Drug Discovery.” ACS Combinatorial Science, vol. 20, no. 6, May. 2018, pp. 335-343. https://doi.org/10.1021/acscombsci.7b00150.