A Parallel Approach to 7-(Hetero)arylpyrazolo[1,5-a]pyrimidin-5-ones
1
Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States
|
2
Department of Chemistry, La Jolla Laboratories, Pfizer Inc., 10770 Science Center Drive, San Diego, California 92121, United States
|
Publication type: Journal Article
Publication date: 2018-04-04
SJR: —
CiteScore: —
Impact factor: —
ISSN: 21568952, 21568944
PubMed ID:
29618198
General Chemistry
General Medicine
Abstract
A modular, two-pot assembly of 7-arylpyrazolo[1,5- a]pyrimidones from aryl/heteroaryl halides and aminopyrazoles in library format was developed. Sonogashira coupling of aryl bromides with triethyl orthopropiolate, followed by in situ orthoester hydrolysis, provides access to β-aryl ynoates, which undergo regioselective cyclocondensation with aminopyrazoles. The ability to vary the C7 vector of 7-arylpyrazolo[1,5- a]pyrimidones in two steps using readily available (hetero)aryl halides significantly enhances synthetic access to this challenging vector.
Found
Nothing found, try to update filter.
Found
Nothing found, try to update filter.
Top-30
Journals
|
1
2
|
|
|
Advances in Heterocyclic Chemistry
2 publications, 18.18%
|
|
|
Current Organic Synthesis
1 publication, 9.09%
|
|
|
Letters in Drug Design and Discovery
1 publication, 9.09%
|
|
|
Molecules
1 publication, 9.09%
|
|
|
Molecular Diversity
1 publication, 9.09%
|
|
|
European Journal of Medicinal Chemistry
1 publication, 9.09%
|
|
|
RSC Advances
1 publication, 9.09%
|
|
|
Progress in Heterocyclic Chemistry
1 publication, 9.09%
|
|
|
1
2
|
Publishers
|
1
2
3
4
|
|
|
Elsevier
4 publications, 36.36%
|
|
|
Bentham Science Publishers Ltd.
2 publications, 18.18%
|
|
|
MDPI
1 publication, 9.09%
|
|
|
Springer Nature
1 publication, 9.09%
|
|
|
Royal Society of Chemistry (RSC)
1 publication, 9.09%
|
|
|
1
2
3
4
|
- We do not take into account publications without a DOI.
- Statistics recalculated weekly.
Are you a researcher?
Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
11
Total citations:
11
Citations from 2024:
0
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Schmitt D. et al. A Parallel Approach to 7-(Hetero)arylpyrazolo[1,5-a]pyrimidin-5-ones // ACS Combinatorial Science. 2018. Vol. 20. No. 5. pp. 256-260.
GOST all authors (up to 50)
Copy
Schmitt D., Niljianskul N., Sach N. W., TRUJILLO J. L. A Parallel Approach to 7-(Hetero)arylpyrazolo[1,5-a]pyrimidin-5-ones // ACS Combinatorial Science. 2018. Vol. 20. No. 5. pp. 256-260.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1021/acscombsci.8b00032
UR - https://doi.org/10.1021/acscombsci.8b00032
TI - A Parallel Approach to 7-(Hetero)arylpyrazolo[1,5-a]pyrimidin-5-ones
T2 - ACS Combinatorial Science
AU - Schmitt, Daniel
AU - Niljianskul, Nootaree
AU - Sach, Neal W.
AU - TRUJILLO, JOHN L.
PY - 2018
DA - 2018/04/04
PB - American Chemical Society (ACS)
SP - 256-260
IS - 5
VL - 20
PMID - 29618198
SN - 2156-8952
SN - 2156-8944
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2018_Schmitt,
author = {Daniel Schmitt and Nootaree Niljianskul and Neal W. Sach and JOHN L. TRUJILLO},
title = {A Parallel Approach to 7-(Hetero)arylpyrazolo[1,5-a]pyrimidin-5-ones},
journal = {ACS Combinatorial Science},
year = {2018},
volume = {20},
publisher = {American Chemical Society (ACS)},
month = {apr},
url = {https://doi.org/10.1021/acscombsci.8b00032},
number = {5},
pages = {256--260},
doi = {10.1021/acscombsci.8b00032}
}
Cite this
MLA
Copy
Schmitt, Daniel, et al. “A Parallel Approach to 7-(Hetero)arylpyrazolo[1,5-a]pyrimidin-5-ones.” ACS Combinatorial Science, vol. 20, no. 5, Apr. 2018, pp. 256-260. https://doi.org/10.1021/acscombsci.8b00032.