Metal–Organic Framework-Remodeled Gut Microbiota Alleviates Colonic Inflammation via Selective Modulation of Roseburia intestinalis
Huijie Hu
1, 2, 3, 4, 5, 6
,
Xiaomin Su
7
,
Lei Su
7
,
Qing Dong
8, 9, 10, 11, 12, 13
,
Qingfeng Dong
10, 11
,
Shuai Yuan
3, 4
,
Shaokang Ding
1, 2, 3, 4, 5, 6
,
Shiqian Ding
3, 4
,
Juxiong Liu
1, 2, 3, 4, 5, 6
,
Bin Xu
14, 15
,
Liqun Tu
16, 17, 18, 19, 20, 21
,
Li Shu Tu
18, 19
,
Xuanting Liu
2, 4, 6, 22, 23, 24
,
Yu Cao
3, 4
,
XINYUE WANG
10, 11
,
Guiying Yang
8, 9, 10, 11, 12, 13
,
G. Sohae Yang
10, 11
,
Wenjin Guo
1, 2, 3, 4, 5, 6, 25, 26, 27, 28, 29
,
Shoupeng Fu
3, 4
,
Daiyong Chao
8, 9, 10, 11, 12, 13
1
State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine
3
State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Changchun, China
|
5
State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Changchun, China
|
8
School of Pharmacy
10
School of Pharmacy, Weifang, PR China
|
12
School of Pharmacy, Weifang, PR China
|
14
College of Animal Science and Veterinary Medicine, Daqing, P. R. China
|
16
Department of Pediatrics
20
Department of Pediatrics, Stanford, United States
|
22
Jilin Provincial Key Laboratory of Nutrition and Functional Food and College of Food Science and Engineering
|
23
Jilin Provincial Key Laboratory of Nutrition and Functional Food and College of Food Science and Engineering, Changchun, China
|
24
Jilin Provincial Key Laboratory of Nutrition and Functional Food and College of Food Science and Engineering, Changchun, China
|
25
ChongQing Research Institute
26
Chongqing Research Institute, Chongqing, China
|
28
Chongqing Research Institute, Chongqing, China
|
Publication type: Journal Article
Publication date: 2025-08-19
scimago Q1
wos Q1
SJR: 4.497
CiteScore: 24.2
Impact factor: 16.0
ISSN: 19360851, 1936086X
Abstract
Inflammatory bowel disease (IBD) is marked by severe colonic inflammation and oxidative stress-induced tissue damage, often accompanied by gut microbiota dysbiosis. Probiotics have recently been recognized as promising therapeutic agents for IBD. Herein, we examined the modulatory effects of orally administered metal-organic framework (MOF) nanozyme MOF-818 on gut microbiota in a mouse model of IBD. Oral treatment with MOF-818 significantly alleviated IBD symptoms, reduced intestinal oxidative damage, and favorably altered the gut microbiota composition. Notably, MOF-818 selectively enhanced the proliferation of Roseburia intestinalis (R. intestinalis). Further analyses showed that MOF-818 significantly upregulated bacterial division-related genes (ftsZ, ftsE) in R. intestinalis while genes associated with ATP synthesis (atpA, atpD) were also highly expressed, boosting energy production to support rapid cell division and proliferation. These findings underscore the biofunctional role of MOF-818 as an active modulator of the gut microflora rather than a passive therapeutic agent, which highlights its significant synergistic potential with probiotics and lays a theoretical foundation for the future application of MOF-based materials in combination with probiotics.
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Hu H. et al. Metal–Organic Framework-Remodeled Gut Microbiota Alleviates Colonic Inflammation via Selective Modulation of Roseburia intestinalis // ACS Nano. 2025. Vol. 19. No. 34. pp. 31107-31125.
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Hu H. et al. Metal–Organic Framework-Remodeled Gut Microbiota Alleviates Colonic Inflammation via Selective Modulation of Roseburia intestinalis // ACS Nano. 2025. Vol. 19. No. 34. pp. 31107-31125.
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TY - JOUR
DO - 10.1021/acsnano.5c09530
UR - https://pubs.acs.org/doi/10.1021/acsnano.5c09530
TI - Metal–Organic Framework-Remodeled Gut Microbiota Alleviates Colonic Inflammation via Selective Modulation of Roseburia intestinalis
T2 - ACS Nano
AU - Hu, Huijie
AU - Su, Xiaomin
AU - Su, Lei
AU - Dong, Qing
AU - Dong, Qingfeng
AU - Yuan, Shuai
AU - Ding, Shaokang
AU - Ding, Shiqian
AU - Liu, Juxiong
AU - Xu, Bin
AU - Tu, Liqun
AU - Tu, Li Shu
AU - Liu, Xuanting
AU - Cao, Yu
AU - WANG, XINYUE
AU - Yang, Guiying
AU - Yang, G. Sohae
AU - Guo, Wenjin
AU - Fu, Shoupeng
AU - Chao, Daiyong
PY - 2025
DA - 2025/08/19
PB - American Chemical Society (ACS)
SP - 31107-31125
IS - 34
VL - 19
SN - 1936-0851
SN - 1936-086X
ER -
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@article{2025_Hu,
author = {Huijie Hu and Xiaomin Su and Lei Su and Qing Dong and Qingfeng Dong and Shuai Yuan and Shaokang Ding and Shiqian Ding and Juxiong Liu and Bin Xu and Liqun Tu and Li Shu Tu and Xuanting Liu and Yu Cao and XINYUE WANG and Guiying Yang and G. Sohae Yang and Wenjin Guo and Shoupeng Fu and Daiyong Chao and others},
title = {Metal–Organic Framework-Remodeled Gut Microbiota Alleviates Colonic Inflammation via Selective Modulation of Roseburia intestinalis},
journal = {ACS Nano},
year = {2025},
volume = {19},
publisher = {American Chemical Society (ACS)},
month = {aug},
url = {https://pubs.acs.org/doi/10.1021/acsnano.5c09530},
number = {34},
pages = {31107--31125},
doi = {10.1021/acsnano.5c09530}
}
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Hu, Huijie, et al. “Metal–Organic Framework-Remodeled Gut Microbiota Alleviates Colonic Inflammation via Selective Modulation of Roseburia intestinalis.” ACS Nano, vol. 19, no. 34, Aug. 2025, pp. 31107-31125. https://pubs.acs.org/doi/10.1021/acsnano.5c09530.