ACS Nano

, volume 12 , issue 6 , pages 5709-5718

Motion-Based Immunological Detection of Zika Virus Using Pt-Nanomotors and a Cellphone

Mohamed Shehata Draz ^{1, 2, 3}

Nivethitha Kota Lakshminaraasimulu ¹

Sanchana Krishnakumar ¹

Dheerendranath Battalapalli ¹

Anish Vasan ¹

M.K. Kanakasabapathy ¹

Aparna Sreeram ¹

Shantanu Kallakuri ¹

P. Thirumalaraju ¹

Yudong Li ¹

Stephane Hua ⁴

Xu Ming Yu ^{4, 5}

Daniel R. Kuritzkes ⁵

Hadi Shafiee ^{1, 2}

Hide authors affiliations Show authors affiliations: 5 affiliations

Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02139, United States

Harvard University

Brigham and Women's Hospital

Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, United States |

Faculty of Science, Tanta University, Tanta 31527, Egypt |

⁴

The Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Boston, Massachusetts 02129, United States

Massachusetts Institute of Technology

Ragon Institute of MGH, MIT and Harvard

⁵

Division of Infectious Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02139, United States

Harvard University

Brigham and Women's Hospital

Publication type: Journal Article

Publication date: 2018-05-16

American Chemical Society (ACS)

ACS Nano

scimago Q1

wos Q1

SJR: 4.497

CiteScore: 24.2

Impact factor: 16.0

ISSN: 19360851, 1936086X

DOI: 10.1021/acsnano.8b01515

Copy DOI

PubMed ID: 29767504

General Physics and Astronomy

General Materials Science

General Engineering

Abstract

Zika virus (ZIKV) infection is an emerging pandemic threat to humans that can be fatal in newborns. Advances in digital health systems and nanoparticles can facilitate the development of sensitive and portable detection technologies for timely management of emerging viral infections. Here we report a nanomotor-based bead-motion cellphone (NBC) system for the immunological detection of ZIKV. The presence of virus in a testing sample results in the accumulation of platinum (Pt)-nanomotors on the surface of beads, causing their motion in H2O2 solution. Then the virus concentration is detected in correlation with the change in beads motion. The developed NBC system was capable of detecting ZIKV in samples with virus concentrations as low as 1 particle/μL. The NBC system allowed a highly specific detection of ZIKV in the presence of the closely related dengue virus and other neurotropic viruses, such as herpes simplex virus type 1 and human cytomegalovirus. The NBC platform technology has the potential to be used in the development of point-of-care diagnostics for pathogen detection and disease management in developed and developing countries.

Found

1 citation

Thirumalaraju Prudhvi

13 publications, 365 citations, 7 reviews

h-index: 6

Harvard University

Brigham and Women's Hospital

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GOST |

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GOST Copy

Draz M. S. et al. Motion-Based Immunological Detection of Zika Virus Using Pt-Nanomotors and a Cellphone // ACS Nano. 2018. Vol. 12. No. 6. pp. 5709-5718.

GOST all authors (up to 50) Copy

Draz M. S., Lakshminaraasimulu N. K., Krishnakumar S., Battalapalli D., Vasan A., Kanakasabapathy M., Sreeram A., Kallakuri S., Thirumalaraju P., Li Y., Hua S., Yu X. M., Kuritzkes D. R., Shafiee H. Motion-Based Immunological Detection of Zika Virus Using Pt-Nanomotors and a Cellphone // ACS Nano. 2018. Vol. 12. No. 6. pp. 5709-5718.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1021/acsnano.8b01515

UR - https://doi.org/10.1021/acsnano.8b01515

TI - Motion-Based Immunological Detection of Zika Virus Using Pt-Nanomotors and a Cellphone

T2 - ACS Nano

AU - Draz, Mohamed Shehata

AU - Lakshminaraasimulu, Nivethitha Kota

AU - Krishnakumar, Sanchana

AU - Battalapalli, Dheerendranath

AU - Vasan, Anish

AU - Kanakasabapathy, M.K.

AU - Sreeram, Aparna

AU - Kallakuri, Shantanu

AU - Thirumalaraju, P.

AU - Li, Yudong

AU - Hua, Stephane

AU - Yu, Xu Ming

AU - Kuritzkes, Daniel R.

AU - Shafiee, Hadi

PY - 2018

DA - 2018/05/16

PB - American Chemical Society (ACS)

SP - 5709-5718

IS - 6

VL - 12

PMID - 29767504

SN - 1936-0851

SN - 1936-086X

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2018_Draz,

author = {Mohamed Shehata Draz and Nivethitha Kota Lakshminaraasimulu and Sanchana Krishnakumar and Dheerendranath Battalapalli and Anish Vasan and M.K. Kanakasabapathy and Aparna Sreeram and Shantanu Kallakuri and P. Thirumalaraju and Yudong Li and Stephane Hua and Xu Ming Yu and Daniel R. Kuritzkes and Hadi Shafiee},

title = {Motion-Based Immunological Detection of Zika Virus Using Pt-Nanomotors and a Cellphone},

journal = {ACS Nano},

year = {2018},

volume = {12},

publisher = {American Chemical Society (ACS)},

month = {may},

url = {https://doi.org/10.1021/acsnano.8b01515},

number = {6},

pages = {5709--5718},

doi = {10.1021/acsnano.8b01515}

}

MLA

Cite this

MLA Copy

Draz, Mohamed Shehata, et al. “Motion-Based Immunological Detection of Zika Virus Using Pt-Nanomotors and a Cellphone.” ACS Nano, vol. 12, no. 6, May. 2018, pp. 5709-5718. https://doi.org/10.1021/acsnano.8b01515.

Publisher

American Chemical Society (ACS)

Journal

ACS Nano

scimago Q1

wos Q1

SJR

4.497

CiteScore

24.2

Impact factor

16.0

ISSN

19360851 (Print)

1936086X (Electronic)