Open Access
Open access
American Chemical Society (ACS)
ACS Omega
,  volume 9 ,  issue 13 ,  pages 15590-15602

Incorporating Network Pharmacology and Experimental Validation to Identify Bioactive Compounds and Potential Mechanisms of Digitalis in Treating Anaplastic Thyroid Cancer

L Zhu 1, 2, 3, 4
, 
Ruimin Liang 3, 4, 5
, 
Yawen Guo 3, 4, 5
, 
Yefeng Cai 3, 4, 6
, 
Fahuan Song 3, 4, 5
, 
Yiqun Hu 3, 4, 5
, 
Yi-qun Hu 3, 4, 5
, 
Yunye Liu 3, 4, 5
, 
Minghua Ge 1, 3, 4, 5
, 
Guowan Zheng 3, 4, 5
1
 
Suzhou Medical College of Soochow University, 215123 Suzhou, Jiangsu, China | 
2
 
3
 
Key Laboratory of Endocrine Gland Diseases of Zhejiang Province, 310014 Hangzhou, Zhejiang, China | 
4
 
Clinical Research Center for Cancer of Zhejiang Province, 310014 Hangzhou, Zhejiang, China | 
5
 
6
 
Publication type: Journal Article
Publication date: 2024-03-20
American Chemical Society (ACS)
scimago Q1
wos Q2
SJR: 0.773
CiteScore: 7.1
Impact factor: 4.3
ISSN: 24701343
General Chemistry
General Chemical Engineering
Abstract
Anaplastic thyroid cancer (ATC) is one of the most lethal malignant tumors for which there is no effective treatment. There are an increasing number of studies on herbal medicine for treating malignant tumors, and the classic botanical medicine Digitalis and its active ingredients for treating heart failure and arrhythmias have been revealed to have significant antitumor efficacy against a wide range of malignant tumors. However, the main components of Digitalis and the molecular mechanisms of its anti-ATC effects have not been extensively studied. Here, we screened the main components and core targets of Digitalis and verified the relationship between the active components and targets through network pharmacology, molecular docking, and experimental validation. These experiments showed that the active ingredients of Digitalis inhibit ATC cell activity and lead to ATC cell death through the apoptotic pathway.
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GOST |
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GOST Copy
Zhu L. et al. Incorporating Network Pharmacology and Experimental Validation to Identify Bioactive Compounds and Potential Mechanisms of Digitalis in Treating Anaplastic Thyroid Cancer // ACS Omega. 2024. Vol. 9. No. 13. pp. 15590-15602.
GOST all authors (up to 50) Copy
Zhu L., Liang R., Guo Y., Cai Y., Song F., Hu Y., Hu Y., Liu Y., Ge M., Zheng G. Incorporating Network Pharmacology and Experimental Validation to Identify Bioactive Compounds and Potential Mechanisms of Digitalis in Treating Anaplastic Thyroid Cancer // ACS Omega. 2024. Vol. 9. No. 13. pp. 15590-15602.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1021/acsomega.4c00373
UR - https://pubs.acs.org/doi/10.1021/acsomega.4c00373
TI - Incorporating Network Pharmacology and Experimental Validation to Identify Bioactive Compounds and Potential Mechanisms of Digitalis in Treating Anaplastic Thyroid Cancer
T2 - ACS Omega
AU - Zhu, L
AU - Liang, Ruimin
AU - Guo, Yawen
AU - Cai, Yefeng
AU - Song, Fahuan
AU - Hu, Yiqun
AU - Hu, Yi-qun
AU - Liu, Yunye
AU - Ge, Minghua
AU - Zheng, Guowan
PY - 2024
DA - 2024/03/20
PB - American Chemical Society (ACS)
SP - 15590-15602
IS - 13
VL - 9
PMID - 38585091
SN - 2470-1343
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2024_Zhu,
author = {L Zhu and Ruimin Liang and Yawen Guo and Yefeng Cai and Fahuan Song and Yiqun Hu and Yi-qun Hu and Yunye Liu and Minghua Ge and Guowan Zheng},
title = {Incorporating Network Pharmacology and Experimental Validation to Identify Bioactive Compounds and Potential Mechanisms of Digitalis in Treating Anaplastic Thyroid Cancer},
journal = {ACS Omega},
year = {2024},
volume = {9},
publisher = {American Chemical Society (ACS)},
month = {mar},
url = {https://pubs.acs.org/doi/10.1021/acsomega.4c00373},
number = {13},
pages = {15590--15602},
doi = {10.1021/acsomega.4c00373}
}
MLA
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MLA Copy
Zhu, L., et al. “Incorporating Network Pharmacology and Experimental Validation to Identify Bioactive Compounds and Potential Mechanisms of Digitalis in Treating Anaplastic Thyroid Cancer.” ACS Omega, vol. 9, no. 13, Mar. 2024, pp. 15590-15602. https://pubs.acs.org/doi/10.1021/acsomega.4c00373.