New analogs of N-(2-aminoethyl)-4-chlorobenzamide (Ro 16-6491). Some of the most potent monoamine oxidase-B inactivators
Publication type: Journal Article
Publication date: 1993-11-01
scimago Q1
wos Q1
SJR: 1.801
CiteScore: 11.5
Impact factor: 6.8
ISSN: 00222623, 15204804
PubMed ID:
8254625
Drug Discovery
Molecular Medicine
Abstract
A series of halo- and nitro-substituted analogues of N-(2-aminoethyl)benzamide has been synthesized. All of the compounds are competitive, time-dependent inhibitors of monoamine oxidase-B (MAO-B), but upon dialysis complete return of enzyme activity is observed for all compounds. Therefore, these are mechanism-based reversible inhibitors of MAO-B. The relative potencies of the compounds are rationalized in terms of steric and hydrophobic effects.
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Total citations:
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GOST
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Annan N. New analogs of N-(2-aminoethyl)-4-chlorobenzamide (Ro 16-6491). Some of the most potent monoamine oxidase-B inactivators // Journal of Medicinal Chemistry. 1993. Vol. 36. No. 24. pp. 3968-3970.
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Annan N. New analogs of N-(2-aminoethyl)-4-chlorobenzamide (Ro 16-6491). Some of the most potent monoamine oxidase-B inactivators // Journal of Medicinal Chemistry. 1993. Vol. 36. No. 24. pp. 3968-3970.
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RIS
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TY - JOUR
DO - 10.1021/jm00076a026
UR - https://doi.org/10.1021/jm00076a026
TI - New analogs of N-(2-aminoethyl)-4-chlorobenzamide (Ro 16-6491). Some of the most potent monoamine oxidase-B inactivators
T2 - Journal of Medicinal Chemistry
AU - Annan, Nikoi
PY - 1993
DA - 1993/11/01
PB - American Chemical Society (ACS)
SP - 3968-3970
IS - 24
VL - 36
PMID - 8254625
SN - 0022-2623
SN - 1520-4804
ER -
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BibTex (up to 50 authors)
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@article{1993_Annan,
author = {Nikoi Annan},
title = {New analogs of N-(2-aminoethyl)-4-chlorobenzamide (Ro 16-6491). Some of the most potent monoamine oxidase-B inactivators},
journal = {Journal of Medicinal Chemistry},
year = {1993},
volume = {36},
publisher = {American Chemical Society (ACS)},
month = {nov},
url = {https://doi.org/10.1021/jm00076a026},
number = {24},
pages = {3968--3970},
doi = {10.1021/jm00076a026}
}
Cite this
MLA
Copy
Annan, Nikoi. “New analogs of N-(2-aminoethyl)-4-chlorobenzamide (Ro 16-6491). Some of the most potent monoamine oxidase-B inactivators.” Journal of Medicinal Chemistry, vol. 36, no. 24, Nov. 1993, pp. 3968-3970. https://doi.org/10.1021/jm00076a026.