Journal of Medicinal Chemistry, volume 28, issue 7, pages 914-921

Synthesis of the antileukemic agents 5,10-dideazaaminopterin and 5,10-dideaza-5,6,7,8-tetrahydroaminopterin

EDWARD C. TAYLOR

Peter J Harrington

Stephen R. Fletcher

G. Peter Beardsley

Richard G. Moran

Show full list: 5 authors

Publication type: Journal Article

Publication date: 1985-07-01

American Chemical Society (ACS)

Journal: Journal of Medicinal Chemistry

scimago Q1

SJR: 1.986

CiteScore: 12.8

Impact factor: 6.8

ISSN: 00222623, 15204804

DOI: 10.1021/jm00145a012

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PubMed ID: 4009615

Drug Discovery

Molecular Medicine

Abstract

Total syntheses from pyridine precursors of 5,10-dideazaaminopterin (1) and 5,10-dideaza-5,6,7,8-tetrahydroaminopterin (2) are described. These compounds exhibit significant in vivo activity against L1210 leukemia that is comparable to that observed with methotrexate.

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n/a Field Citation Ratio

3.98 Relative Citation Ratio

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GOST |

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GOST Copy

TAYLOR E. C. et al. Synthesis of the antileukemic agents 5,10-dideazaaminopterin and 5,10-dideaza-5,6,7,8-tetrahydroaminopterin // Journal of Medicinal Chemistry. 1985. Vol. 28. No. 7. pp. 914-921.

GOST all authors (up to 50) Copy

TAYLOR E. C., Harrington P. J., Fletcher S. R., Beardsley G. P., Moran R. G. Synthesis of the antileukemic agents 5,10-dideazaaminopterin and 5,10-dideaza-5,6,7,8-tetrahydroaminopterin // Journal of Medicinal Chemistry. 1985. Vol. 28. No. 7. pp. 914-921.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1021/jm00145a012

UR - https://doi.org/10.1021/jm00145a012

TI - Synthesis of the antileukemic agents 5,10-dideazaaminopterin and 5,10-dideaza-5,6,7,8-tetrahydroaminopterin

T2 - Journal of Medicinal Chemistry

AU - TAYLOR, EDWARD C.

AU - Harrington, Peter J

AU - Fletcher, Stephen R.

AU - Beardsley, G. Peter

AU - Moran, Richard G.

PY - 1985

DA - 1985/07/01

PB - American Chemical Society (ACS)

SP - 914-921

IS - 7

VL - 28

PMID - 4009615

SN - 0022-2623

SN - 1520-4804

ER -

BibTex |

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BibTex (up to 50 authors) Copy

@article{1985_TAYLOR,

author = {EDWARD C. TAYLOR and Peter J Harrington and Stephen R. Fletcher and G. Peter Beardsley and Richard G. Moran},

title = {Synthesis of the antileukemic agents 5,10-dideazaaminopterin and 5,10-dideaza-5,6,7,8-tetrahydroaminopterin},

journal = {Journal of Medicinal Chemistry},

year = {1985},

volume = {28},

publisher = {American Chemical Society (ACS)},

month = {jul},

url = {https://doi.org/10.1021/jm00145a012},

number = {7},

pages = {914--921},

doi = {10.1021/jm00145a012}

}

MLA

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MLA Copy

TAYLOR, EDWARD C., et al. “Synthesis of the antileukemic agents 5,10-dideazaaminopterin and 5,10-dideaza-5,6,7,8-tetrahydroaminopterin.” Journal of Medicinal Chemistry, vol. 28, no. 7, Jul. 1985, pp. 914-921. https://doi.org/10.1021/jm00145a012.

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Publisher

American Chemical Society (ACS)

Journal

Journal of Medicinal Chemistry

scimago Q1

SJR

1.986

CiteScore

12.8

Impact factor

6.8

ISSN

00222623 (Print)

15204804 (Electronic)