2-Azabicyclo[2.2.2]octane analogues of the prodine analgetics
Publication type: Journal Article
Publication date: 1976-06-01
scimago Q1
wos Q1
SJR: 1.801
CiteScore: 11.5
Impact factor: 6.8
ISSN: 00222623, 15204804
PubMed ID:
950659
Drug Discovery
Molecular Medicine
Abstract
The synthesis and analgetic activity of analogues of prodine-type analgetics in which the conformation of the piperidine ring is restricted in the boat form using the 2-azabicyclo (2.2.2)octane nucleus are reported. One of these analogues, 2-methyl-6-trans-phenyl-6-cis-propionoxy-2-azabicyclo (2.2.2)octane (3), showed significant analgetic activity (ED50 equals 3.1 mg/kg).
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Metrics
11
Total citations:
11
Citations from 2025:
1
(9.09%)
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GOST
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Clark C. R., HOLBROOK J. M., Borne R. F. 2-Azabicyclo[2.2.2]octane analogues of the prodine analgetics // Journal of Medicinal Chemistry. 1976. Vol. 19. No. 6. pp. 852-854.
GOST all authors (up to 50)
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Clark C. R., HOLBROOK J. M., Borne R. F. 2-Azabicyclo[2.2.2]octane analogues of the prodine analgetics // Journal of Medicinal Chemistry. 1976. Vol. 19. No. 6. pp. 852-854.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1021/jm00228a027
UR - https://doi.org/10.1021/jm00228a027
TI - 2-Azabicyclo[2.2.2]octane analogues of the prodine analgetics
T2 - Journal of Medicinal Chemistry
AU - Clark, C Randall
AU - HOLBROOK, JOHN M.
AU - Borne, Ronald F
PY - 1976
DA - 1976/06/01
PB - American Chemical Society (ACS)
SP - 852-854
IS - 6
VL - 19
PMID - 950659
SN - 0022-2623
SN - 1520-4804
ER -
Cite this
BibTex (up to 50 authors)
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@article{1976_Clark,
author = {C Randall Clark and JOHN M. HOLBROOK and Ronald F Borne},
title = {2-Azabicyclo[2.2.2]octane analogues of the prodine analgetics},
journal = {Journal of Medicinal Chemistry},
year = {1976},
volume = {19},
publisher = {American Chemical Society (ACS)},
month = {jun},
url = {https://doi.org/10.1021/jm00228a027},
number = {6},
pages = {852--854},
doi = {10.1021/jm00228a027}
}
Cite this
MLA
Copy
Clark, C. Randall, et al. “2-Azabicyclo[2.2.2]octane analogues of the prodine analgetics.” Journal of Medicinal Chemistry, vol. 19, no. 6, Jun. 1976, pp. 852-854. https://doi.org/10.1021/jm00228a027.