Antiallergics: 3-(1H-tetrazol-5-yl)-4H-pyrimido[2,1-b]benzothiazol-4-ones
Publication type: Journal Article
Publication date: 1982-07-01
scimago Q1
wos Q1
SJR: 1.801
CiteScore: 11.5
Impact factor: 6.8
ISSN: 00222623, 15204804
PubMed ID:
7108903
Drug Discovery
Molecular Medicine
Abstract
A short series of the title compounds was prepared and evaluated for both antiallergic and bronchodilator activity. Members of the series exhibit good oral activity in the rat PCA test, the most potent being the parent compound, 3-(1H-tetrazol-5-yl)-4H-pyrimido[2,1-b]benzothiazol-4-one, and its 8-chloro derivative. The latter two compounds are considerably more potent than either disodium chromoglycate or theophylline as antiallergic agents and also show significant bronchodilator activity.
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Metrics
33
Total citations:
33
Citations from 2024:
2
(6.06%)
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GOST
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Yevich J. P. et al. Antiallergics: 3-(1H-tetrazol-5-yl)-4H-pyrimido[2,1-b]benzothiazol-4-ones // Journal of Medicinal Chemistry. 1982. Vol. 25. No. 7. pp. 864-868.
GOST all authors (up to 50)
Copy
Yevich J. P., Temple D. L., Covington R. R., OWENS D. A., Seidehamel R., Dungan K. W. Antiallergics: 3-(1H-tetrazol-5-yl)-4H-pyrimido[2,1-b]benzothiazol-4-ones // Journal of Medicinal Chemistry. 1982. Vol. 25. No. 7. pp. 864-868.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1021/jm00349a020
UR - https://doi.org/10.1021/jm00349a020
TI - Antiallergics: 3-(1H-tetrazol-5-yl)-4H-pyrimido[2,1-b]benzothiazol-4-ones
T2 - Journal of Medicinal Chemistry
AU - Yevich, J P
AU - Temple, D. L.
AU - Covington, R R
AU - OWENS, D. A.
AU - Seidehamel, R.J.
AU - Dungan, K W
PY - 1982
DA - 1982/07/01
PB - American Chemical Society (ACS)
SP - 864-868
IS - 7
VL - 25
PMID - 7108903
SN - 0022-2623
SN - 1520-4804
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{1982_Yevich,
author = {J P Yevich and D. L. Temple and R R Covington and D. A. OWENS and R.J. Seidehamel and K W Dungan},
title = {Antiallergics: 3-(1H-tetrazol-5-yl)-4H-pyrimido[2,1-b]benzothiazol-4-ones},
journal = {Journal of Medicinal Chemistry},
year = {1982},
volume = {25},
publisher = {American Chemical Society (ACS)},
month = {jul},
url = {https://doi.org/10.1021/jm00349a020},
number = {7},
pages = {864--868},
doi = {10.1021/jm00349a020}
}
Cite this
MLA
Copy
Yevich, J. P., et al. “Antiallergics: 3-(1H-tetrazol-5-yl)-4H-pyrimido[2,1-b]benzothiazol-4-ones.” Journal of Medicinal Chemistry, vol. 25, no. 7, Jul. 1982, pp. 864-868. https://doi.org/10.1021/jm00349a020.