Synthesis and biological properties of some 6H-pyrido[4,3-b]carbazoles
Publication type: Journal Article
Publication date: 1987-07-01
scimago Q1
wos Q1
SJR: 1.801
CiteScore: 11.5
Impact factor: 6.8
ISSN: 00222623, 15204804
PubMed ID:
3599025
Drug Discovery
Molecular Medicine
Abstract
The effect of methyl substitution on the biological properties of the ellipticines was reexamined. 9-Hydroxy-6H-pyrido[4,3-b]carbazole was synthesized and shown to be devoid of antitumor activity in murine P388 lymphocytic leukemia in mice. 5-(Hydroxymethyl)-11-methyl-6H-pyrido[4,3-b]carbazole (46) and its N-methylcarbamate (48) were synthesized and their effect on macromolecular synthesis in HeLa cells and their antitumor properties were compared with those of ellipticine. In contrast to the alkaloid 1 and the hydroxymethyl derivative 46, which produced partially reversible inhibition of [3H]thymidine incorporation, the carbamate ester irreversibly blocked incorporation of the tritiated pyrimidine. The ester was also a more potent antitumor agent in P388 lymphocytic leukemia than 1 or 46.
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30
Total citations:
30
Citations from 2024:
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(3.33%)
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MLA
Cite this
GOST
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Archer S. et al. Synthesis and biological properties of some 6H-pyrido[4,3-b]carbazoles // Journal of Medicinal Chemistry. 1987. Vol. 30. No. 7. pp. 1204-1210.
GOST all authors (up to 50)
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Archer S., Ross B. S., PICA-MATTOCCIA L., Cioli D. Synthesis and biological properties of some 6H-pyrido[4,3-b]carbazoles // Journal of Medicinal Chemistry. 1987. Vol. 30. No. 7. pp. 1204-1210.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1021/jm00390a014
UR - https://doi.org/10.1021/jm00390a014
TI - Synthesis and biological properties of some 6H-pyrido[4,3-b]carbazoles
T2 - Journal of Medicinal Chemistry
AU - Archer, Sydney
AU - Ross, Bruce S
AU - PICA-MATTOCCIA, LIVIA
AU - Cioli, Donato
PY - 1987
DA - 1987/07/01
PB - American Chemical Society (ACS)
SP - 1204-1210
IS - 7
VL - 30
PMID - 3599025
SN - 0022-2623
SN - 1520-4804
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{1987_Archer,
author = {Sydney Archer and Bruce S Ross and LIVIA PICA-MATTOCCIA and Donato Cioli},
title = {Synthesis and biological properties of some 6H-pyrido[4,3-b]carbazoles},
journal = {Journal of Medicinal Chemistry},
year = {1987},
volume = {30},
publisher = {American Chemical Society (ACS)},
month = {jul},
url = {https://doi.org/10.1021/jm00390a014},
number = {7},
pages = {1204--1210},
doi = {10.1021/jm00390a014}
}
Cite this
MLA
Copy
Archer, Sydney, et al. “Synthesis and biological properties of some 6H-pyrido[4,3-b]carbazoles.” Journal of Medicinal Chemistry, vol. 30, no. 7, Jul. 1987, pp. 1204-1210. https://doi.org/10.1021/jm00390a014.