Journal of Medicinal Chemistry, volume 58, issue 5, pages 2206-2220
Activity of 2-Aryl-2-(3-indolyl)acetohydroxamates against Drug-Resistant Cancer Cells
Smirnov Alexander N
1
,
Magedov Igor V.
2
,
Reisenauer Mary R
2
,
Aksenova Inna V.
1
,
Pendleton Alexander L
2
,
Nguyen Gina
2
,
Johnston Robert K
2
,
Rubin Michael
3
,
Carvalho Annelise
4
,
Kiss Robert
4
,
MATHIEU VÉRONIQUE
4
,
Lefranc Florence
5
,
Correa Jaime
6
,
Cavazos David A.
7
,
Brenner A.
7
,
BRYAN BRAD A.
8
,
Rogelj Snezna
2
,
Kornienko Alexander
6
,
Frolova Liliya V.
2
2
Departments
of Chemistry and Biology, New Mexico Institute of Mining and Technology, Socorro, New Mexico 87801, United States
|
3
Department
of Chemistry, University of Kansas, 1251 Wescoe Hall Drive, Lawrence, Kansas 66045, United States
|
6
Department
of Chemistry and Biochemistry, Texas State University, San Marcos, Texas 78666, United States
|
7
Cancer
Therapy and Research Center, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San
Antonio, Texas 78229, United States
|
8
Department
of Biomedical Sciences, Texas Tech University Health Sciences Center, Center of Excellence in Cancer Research, Paul Foster School of Medicine, 5001 El Paso Drive, El Paso, Texas 79912, United States
|
Publication type: Journal Article
Publication date: 2015-02-20
Journal:
Journal of Medicinal Chemistry
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 7.3
ISSN: 00222623, 15204804
PubMed ID:
25671501
Drug Discovery
Molecular Medicine
Abstract
Many types of tumor, including glioma, melanoma, non-small cell lung, esophageal, and head and neck cancer, among others, are intrinsically resistant to apoptosis induction and poorly responsive to current therapies with proapoptotic agents. In addition, tumors often develop multidrug resistance based on the cellular efflux of chemotherapeutic agents. Thus, novel anticancer agents capable of overcoming these intrinsic or developed tumor resistance mechanisms are urgently needed. We describe a series of 2-aryl-2-(3-indolyl)acetohydroxamic acids that are active against apoptosis- and multidrug-resistant cancer cells as well as glioblastoma neurosphere stemlike cell cultures derived from patients. Thus, the described compounds serve as a novel chemical scaffold for the development of potentially highly effective clinical cancer drugs.
Citations by journals
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1
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7
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RSC Advances
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RSC Advances
7 publications, 15.22%
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Journal of Organic Chemistry
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5 publications, 10.87%
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Chemistry of Heterocyclic Compounds
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Chemistry of Heterocyclic Compounds
4 publications, 8.7%
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European Journal of Medicinal Chemistry
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4 publications, 8.7%
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Tetrahedron Letters
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Tetrahedron Letters
3 publications, 6.52%
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Molecules
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Molecules
2 publications, 4.35%
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ChemMedChem
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ChemMedChem
2 publications, 4.35%
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Journal of Medicinal Chemistry
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Journal of Medicinal Chemistry
2 publications, 4.35%
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Chemical Communications
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Chemical Communications
2 publications, 4.35%
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Russian Journal of Organic Chemistry
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Russian Journal of Organic Chemistry
1 publication, 2.17%
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Mendeleev Communications
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Mendeleev Communications
1 publication, 2.17%
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MolBank
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MolBank
1 publication, 2.17%
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Investigational New Drugs
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Investigational New Drugs
1 publication, 2.17%
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Medicinal Chemistry Research
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Medicinal Chemistry Research
1 publication, 2.17%
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iScience
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iScience
1 publication, 2.17%
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Tetrahedron
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Tetrahedron
1 publication, 2.17%
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Organic and Biomolecular Chemistry
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Organic and Biomolecular Chemistry
1 publication, 2.17%
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Journal of Biomolecular Structure and Dynamics
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Journal of Biomolecular Structure and Dynamics
1 publication, 2.17%
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Synthetic Communications
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Synthetic Communications
1 publication, 2.17%
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IEEE Transactions on Biomedical Engineering
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IEEE Transactions on Biomedical Engineering
1 publication, 2.17%
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Russian Chemical Bulletin
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Russian Chemical Bulletin
1 publication, 2.17%
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Synlett
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Synlett
1 publication, 2.17%
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Bioorganic and Medicinal Chemistry Letters
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Bioorganic and Medicinal Chemistry Letters
1 publication, 2.17%
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1
2
3
4
5
6
7
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Citations by publishers
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2
4
6
8
10
12
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Elsevier
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Elsevier
11 publications, 23.91%
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Royal Society of Chemistry (RSC)
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Royal Society of Chemistry (RSC)
10 publications, 21.74%
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Springer Nature
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Springer Nature
7 publications, 15.22%
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American Chemical Society (ACS)
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American Chemical Society (ACS)
7 publications, 15.22%
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
3 publications, 6.52%
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Wiley
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Wiley
2 publications, 4.35%
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Taylor & Francis
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Taylor & Francis
2 publications, 4.35%
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Pleiades Publishing
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Pleiades Publishing
1 publication, 2.17%
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IEEE
|
IEEE
1 publication, 2.17%
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Thieme
|
Thieme
1 publication, 2.17%
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2
4
6
8
10
12
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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GOST
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Aksenov A. et al. Activity of 2-Aryl-2-(3-indolyl)acetohydroxamates against Drug-Resistant Cancer Cells // Journal of Medicinal Chemistry. 2015. Vol. 58. No. 5. pp. 2206-2220.
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Aksenov A., Smirnov A. N., Magedov I. V., Reisenauer M. R., Aksenov N. A., Aksenova I. V., Pendleton A. L., Nguyen G., Johnston R. K., Rubin M., Carvalho A., Kiss R., MATHIEU V., Lefranc F., Correa J., Cavazos D. A., Brenner A., BRYAN B. A., Rogelj S., Kornienko A., Frolova L. V. Activity of 2-Aryl-2-(3-indolyl)acetohydroxamates against Drug-Resistant Cancer Cells // Journal of Medicinal Chemistry. 2015. Vol. 58. No. 5. pp. 2206-2220.
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TY - JOUR
DO - 10.1021/jm501518y
UR - https://doi.org/10.1021%2Fjm501518y
TI - Activity of 2-Aryl-2-(3-indolyl)acetohydroxamates against Drug-Resistant Cancer Cells
T2 - Journal of Medicinal Chemistry
AU - Smirnov, Alexander N
AU - Magedov, Igor V.
AU - Reisenauer, Mary R
AU - Nguyen, Gina
AU - MATHIEU, VÉRONIQUE
AU - Correa, Jaime
AU - Cavazos, David A.
AU - Aksenov, Alexander V.
AU - Aksenov, Nicolai A.
AU - Aksenova, Inna V.
AU - Pendleton, Alexander L
AU - Johnston, Robert K
AU - Rubin, Michael
AU - Carvalho, Annelise
AU - Kiss, Robert
AU - Lefranc, Florence
AU - Brenner, A.
AU - BRYAN, BRAD A.
AU - Rogelj, Snezna
AU - Kornienko, Alexander
AU - Frolova, Liliya V.
PY - 2015
DA - 2015/02/20 00:00:00
PB - American Chemical Society (ACS)
SP - 2206-2220
IS - 5
VL - 58
PMID - 25671501
SN - 0022-2623
SN - 1520-4804
ER -
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@article{2015_Aksenov,
author = {Alexander N Smirnov and Igor V. Magedov and Mary R Reisenauer and Gina Nguyen and VÉRONIQUE MATHIEU and Jaime Correa and David A. Cavazos and Alexander V. Aksenov and Nicolai A. Aksenov and Inna V. Aksenova and Alexander L Pendleton and Robert K Johnston and Michael Rubin and Annelise Carvalho and Robert Kiss and Florence Lefranc and A. Brenner and BRAD A. BRYAN and Snezna Rogelj and Alexander Kornienko and Liliya V. Frolova},
title = {Activity of 2-Aryl-2-(3-indolyl)acetohydroxamates against Drug-Resistant Cancer Cells},
journal = {Journal of Medicinal Chemistry},
year = {2015},
volume = {58},
publisher = {American Chemical Society (ACS)},
month = {feb},
url = {https://doi.org/10.1021%2Fjm501518y},
number = {5},
pages = {2206--2220},
doi = {10.1021/jm501518y}
}
Cite this
MLA
Copy
Aksenov, Alexander V., et al. “Activity of 2-Aryl-2-(3-indolyl)acetohydroxamates against Drug-Resistant Cancer Cells.” Journal of Medicinal Chemistry, vol. 58, no. 5, Feb. 2015, pp. 2206-2220. https://doi.org/10.1021%2Fjm501518y.