A Simple Method of Synthesis of (±)-2,3-Diarylpiperazines and a Novel Method of Resolution of (±)-2,3-Diphenylpiperazine
Publication type: Journal Article
Publication date: 2006-04-01
scimago Q2
wos Q1
SJR: 0.737
CiteScore: 6.1
Impact factor: 3.6
ISSN: 00223263, 15206904
PubMed ID:
16626156
Organic Chemistry
Abstract
Intramolecular reductive coupling of diimines in the presence of Zn/Ti(O(i)Pr)2Cl2 gives the corresponding (+/-)-2,3-diarylpiperazines in 73-83% yields with dl/meso ratio >99%:<1%. The (+/-)-2,3-diphenylpiperazine obtained in this way was readily resolved partially using L-(+)-tartaric acid, and the enantiomeric purity was enhanced to >99% ee via preparation of hydrogen-bonded salt aggregates using oxalic acid.
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Total citations:
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Citations from 2024:
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GOST
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Vairaprakash P., PERIASAMY M. P. A Simple Method of Synthesis of (±)-2,3-Diarylpiperazines and a Novel Method of Resolution of (±)-2,3-Diphenylpiperazine // Journal of Organic Chemistry. 2006. Vol. 71. No. 9. pp. 3636-3638.
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Vairaprakash P., PERIASAMY M. P. A Simple Method of Synthesis of (±)-2,3-Diarylpiperazines and a Novel Method of Resolution of (±)-2,3-Diphenylpiperazine // Journal of Organic Chemistry. 2006. Vol. 71. No. 9. pp. 3636-3638.
Cite this
RIS
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TY - JOUR
DO - 10.1021/jo060083n
UR - https://doi.org/10.1021/jo060083n
TI - A Simple Method of Synthesis of (±)-2,3-Diarylpiperazines and a Novel Method of Resolution of (±)-2,3-Diphenylpiperazine
T2 - Journal of Organic Chemistry
AU - Vairaprakash, Pothiappan
AU - PERIASAMY, M. PERI
PY - 2006
DA - 2006/04/01
PB - American Chemical Society (ACS)
SP - 3636-3638
IS - 9
VL - 71
PMID - 16626156
SN - 0022-3263
SN - 1520-6904
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2006_Vairaprakash,
author = {Pothiappan Vairaprakash and M. PERI PERIASAMY},
title = {A Simple Method of Synthesis of (±)-2,3-Diarylpiperazines and a Novel Method of Resolution of (±)-2,3-Diphenylpiperazine},
journal = {Journal of Organic Chemistry},
year = {2006},
volume = {71},
publisher = {American Chemical Society (ACS)},
month = {apr},
url = {https://doi.org/10.1021/jo060083n},
number = {9},
pages = {3636--3638},
doi = {10.1021/jo060083n}
}
Cite this
MLA
Copy
Vairaprakash, Pothiappan, and M. PERI PERIASAMY. “A Simple Method of Synthesis of (±)-2,3-Diarylpiperazines and a Novel Method of Resolution of (±)-2,3-Diphenylpiperazine.” Journal of Organic Chemistry, vol. 71, no. 9, Apr. 2006, pp. 3636-3638. https://doi.org/10.1021/jo060083n.