volume 73 issue 9 pages 3662-3665

Concise Synthesis of (S)-N-BOC-2-Hydroxymethylmorpholine and (S)-N-BOC-Morpholine-2-carboxylic Acid

Kevin E Henegar 1
1
 
Pfizer Global Research and Development, Groton Laboratories, Eastern Point Road, Groton Connecticut 06340
Publication typeJournal Article
Publication date2008-03-26
scimago Q2
wos Q1
SJR0.737
CiteScore6.1
Impact factor3.6
ISSN00223263, 15206904
PubMed ID:  18363360
Organic Chemistry
Abstract
An operationally simple synthesis of N-BOC-2-hydroxymethylmorpholine (1) and N-BOC-morpholine-2-carboxylic acid (2) from epichlorohydrin has been developed. No chromatography is required in the processing, which allows high process throughput.
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GOST Copy
Henegar K. E. Concise Synthesis of (S)-N-BOC-2-Hydroxymethylmorpholine and (S)-N-BOC-Morpholine-2-carboxylic Acid // Journal of Organic Chemistry. 2008. Vol. 73. No. 9. pp. 3662-3665.
GOST all authors (up to 50) Copy
Henegar K. E. Concise Synthesis of (S)-N-BOC-2-Hydroxymethylmorpholine and (S)-N-BOC-Morpholine-2-carboxylic Acid // Journal of Organic Chemistry. 2008. Vol. 73. No. 9. pp. 3662-3665.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1021/jo800356q
UR - https://doi.org/10.1021/jo800356q
TI - Concise Synthesis of (S)-N-BOC-2-Hydroxymethylmorpholine and (S)-N-BOC-Morpholine-2-carboxylic Acid
T2 - Journal of Organic Chemistry
AU - Henegar, Kevin E
PY - 2008
DA - 2008/03/26
PB - American Chemical Society (ACS)
SP - 3662-3665
IS - 9
VL - 73
PMID - 18363360
SN - 0022-3263
SN - 1520-6904
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2008_Henegar,
author = {Kevin E Henegar},
title = {Concise Synthesis of (S)-N-BOC-2-Hydroxymethylmorpholine and (S)-N-BOC-Morpholine-2-carboxylic Acid},
journal = {Journal of Organic Chemistry},
year = {2008},
volume = {73},
publisher = {American Chemical Society (ACS)},
month = {mar},
url = {https://doi.org/10.1021/jo800356q},
number = {9},
pages = {3662--3665},
doi = {10.1021/jo800356q}
}
MLA
Cite this
MLA Copy
Henegar, Kevin E.. “Concise Synthesis of (S)-N-BOC-2-Hydroxymethylmorpholine and (S)-N-BOC-Morpholine-2-carboxylic Acid.” Journal of Organic Chemistry, vol. 73, no. 9, Mar. 2008, pp. 3662-3665. https://doi.org/10.1021/jo800356q.