Journal of Organic Chemistry, volume 73, issue 9, pages 3662-3665

Concise Synthesis of (S)-N-BOC-2-Hydroxymethylmorpholine and (S)-N-BOC-Morpholine-2-carboxylic Acid

Kevin E Henegar ¹

Hide authors affiliations

Pfizer Global Research and Development, Groton Laboratories, Eastern Point Road, Groton Connecticut 06340 |

Publication type: Journal Article

Publication date: 2008-03-26

American Chemical Society (ACS)

Journal: Journal of Organic Chemistry

scimago Q2

SJR: 0.724

CiteScore: 6.2

Impact factor: 3.3

ISSN: 00223263, 15206904

DOI: 10.1021/jo800356q

Copy DOI

PubMed ID: 18363360

Organic Chemistry

Abstract

An operationally simple synthesis of N-BOC-2-hydroxymethylmorpholine (1) and N-BOC-morpholine-2-carboxylic acid (2) from epichlorohydrin has been developed. No chromatography is required in the processing, which allows high process throughput.

Found

	1 2 3
Journal of Organic Chemistry	Journal of Organic Chemistry, 3, 16.67% Journal of Organic Chemistry 3 publications, 16.67%
Synthesis	Synthesis, 2, 11.11% Synthesis 2 publications, 11.11%
Amino Acids	Amino Acids, 1, 5.56% Amino Acids 1 publication, 5.56%
Tetrahedron Letters	Tetrahedron Letters, 1, 5.56% Tetrahedron Letters 1 publication, 5.56%
Tetrahedron Asymmetry	Tetrahedron Asymmetry, 1, 5.56% Tetrahedron Asymmetry 1 publication, 5.56%
Nuclear Medicine and Biology	Nuclear Medicine and Biology, 1, 5.56% Nuclear Medicine and Biology 1 publication, 5.56%
Tetrahedron	Tetrahedron, 1, 5.56% Tetrahedron 1 publication, 5.56%
Organic Letters	Organic Letters, 1, 5.56% Organic Letters 1 publication, 5.56%
Chemical Reviews	Chemical Reviews, 1, 5.56% Chemical Reviews 1 publication, 5.56%
Organic and Biomolecular Chemistry	Organic and Biomolecular Chemistry, 1, 5.56% Organic and Biomolecular Chemistry 1 publication, 5.56%
Chemical Communications	Chemical Communications, 1, 5.56% Chemical Communications 1 publication, 5.56%
Chemical Science	Chemical Science, 1, 5.56% Chemical Science 1 publication, 5.56%
Russian Journal of Organic Chemistry	Russian Journal of Organic Chemistry, 1, 5.56% Russian Journal of Organic Chemistry 1 publication, 5.56%
Synthetic Communications	Synthetic Communications, 1, 5.56% Synthetic Communications 1 publication, 5.56%
Progress in Heterocyclic Chemistry	Progress in Heterocyclic Chemistry, 1, 5.56% Progress in Heterocyclic Chemistry 1 publication, 5.56%
	1 2 3

	1 2 3 4 5
Elsevier	Elsevier, 5, 27.78% Elsevier 5 publications, 27.78%
American Chemical Society (ACS)	American Chemical Society (ACS), 5, 27.78% American Chemical Society (ACS) 5 publications, 27.78%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 3, 16.67% Royal Society of Chemistry (RSC) 3 publications, 16.67%
Georg Thieme Verlag KG	Georg Thieme Verlag KG, 2, 11.11% Georg Thieme Verlag KG 2 publications, 11.11%
Springer Nature	Springer Nature, 1, 5.56% Springer Nature 1 publication, 5.56%
Pleiades Publishing	Pleiades Publishing, 1, 5.56% Pleiades Publishing 1 publication, 5.56%
Taylor & Francis	Taylor & Francis, 1, 5.56% Taylor & Francis 1 publication, 5.56%
	1 2 3 4 5

Are you a researcher?

Create a profile to get free access to personal recommendations for colleagues and new articles.

Metrics

Cite this

GOST | RIS | BibTex | MLA

Found error?

Publisher

American Chemical Society (ACS)

Journal

Journal of Organic Chemistry

scimago Q2

SJR

0.724

CiteScore

6.2

Impact factor

3.3

ISSN

00223263 (Print)

15206904 (Electronic)

Concise Synthesis of (S)-N-BOC-2-Hydroxymethylmorpholine and (S)-N-BOC-Morpholine-2-carboxylic Acid

Top-30

Journals

Publishers

Are you a researcher?