Organic Process Research and Development, volume 5, issue 2, pages 110-115
A Large-Scale Synthesis of Enantiomerically Pure Cetirizine Dihydrochloride Using Preparative Chiral HPLC
Derek A. Pflum
1
,
H.Scott Wilkinson
1
,
Gerald J. Tanoury
1
,
Donald W. Kessler
1
,
Hali B Kraus
1
,
Chris H. Senanayake
1
,
Stephen A Wald
1
1
Sepracor, Inc., Chemical Research and Development, 111 Locke Drive, Marlborough, Massachusetts 01752
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Publication type: Journal Article
Publication date: 2000-12-08
scimago Q1
SJR: 0.900
CiteScore: 6.9
Impact factor: 3.1
ISSN: 10836160, 1520586X
Organic Chemistry
Physical and Theoretical Chemistry
Abstract
Enantiomerically pure cetirizine can be prepared by preparative HPLC separation of cetirizine amide. The amide has an α value of 2.76 (USP resolution of 8.54) using a Chiralpak AD column, and 0.5 wt % of the amide (based on packing material) can be injected per run.
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