A Large-Scale Synthesis of Enantiomerically Pure Cetirizine Dihydrochloride Using Preparative Chiral HPLC
Derek A. Pflum
1
,
H.Scott Wilkinson
1
,
Gerald J. Tanoury
1
,
Donald W. Kessler
1
,
Hali B Kraus
1
,
Chris H. Senanayake
1
,
Stephen A Wald
1
1
Sepracor, Inc., Chemical Research and Development, 111 Locke Drive, Marlborough, Massachusetts 01752
|
Publication type: Journal Article
Publication date: 2000-12-08
scimago Q1
wos Q1
SJR: 0.865
CiteScore: 5.4
Impact factor: 3.5
ISSN: 10836160, 1520586X
Organic Chemistry
Physical and Theoretical Chemistry
Abstract
Enantiomerically pure cetirizine can be prepared by preparative HPLC separation of cetirizine amide. The amide has an α value of 2.76 (USP resolution of 8.54) using a Chiralpak AD column, and 0.5 wt % of the amide (based on packing material) can be injected per run.
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32
Total citations:
32
Citations from 2024:
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Pflum D. A. et al. A Large-Scale Synthesis of Enantiomerically Pure Cetirizine Dihydrochloride Using Preparative Chiral HPLC // Organic Process Research and Development. 2000. Vol. 5. No. 2. pp. 110-115.
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Pflum D. A., Wilkinson H., Tanoury G. J., Kessler D. W., Kraus H. B., Senanayake C. H., Wald S. A. A Large-Scale Synthesis of Enantiomerically Pure Cetirizine Dihydrochloride Using Preparative Chiral HPLC // Organic Process Research and Development. 2000. Vol. 5. No. 2. pp. 110-115.
Cite this
RIS
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TY - JOUR
DO - 10.1021/op0002951
UR - https://doi.org/10.1021/op0002951
TI - A Large-Scale Synthesis of Enantiomerically Pure Cetirizine Dihydrochloride Using Preparative Chiral HPLC
T2 - Organic Process Research and Development
AU - Pflum, Derek A.
AU - Wilkinson, H.Scott
AU - Tanoury, Gerald J.
AU - Kessler, Donald W.
AU - Kraus, Hali B
AU - Senanayake, Chris H.
AU - Wald, Stephen A
PY - 2000
DA - 2000/12/08
PB - American Chemical Society (ACS)
SP - 110-115
IS - 2
VL - 5
SN - 1083-6160
SN - 1520-586X
ER -
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BibTex (up to 50 authors)
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@article{2000_Pflum,
author = {Derek A. Pflum and H.Scott Wilkinson and Gerald J. Tanoury and Donald W. Kessler and Hali B Kraus and Chris H. Senanayake and Stephen A Wald},
title = {A Large-Scale Synthesis of Enantiomerically Pure Cetirizine Dihydrochloride Using Preparative Chiral HPLC},
journal = {Organic Process Research and Development},
year = {2000},
volume = {5},
publisher = {American Chemical Society (ACS)},
month = {dec},
url = {https://doi.org/10.1021/op0002951},
number = {2},
pages = {110--115},
doi = {10.1021/op0002951}
}
Cite this
MLA
Copy
Pflum, Derek A., et al. “A Large-Scale Synthesis of Enantiomerically Pure Cetirizine Dihydrochloride Using Preparative Chiral HPLC.” Organic Process Research and Development, vol. 5, no. 2, Dec. 2000, pp. 110-115. https://doi.org/10.1021/op0002951.