Development of a Manufacturing Process for Zatosetron Maleate
Publication type: Journal Article
Publication date: 1997-05-01
scimago Q1
wos Q1
SJR: 0.865
CiteScore: 5.4
Impact factor: 3.5
ISSN: 10836160, 1520586X
Organic Chemistry
Physical and Theoretical Chemistry
Abstract
Zatosetron maleate is a potent, selective 5-hydroxytryptamine receptor antagonist. In anticipation of commercialization, a manufacturing synthesis of zatosetron from tropinone and 5-chlorosalicylic acid was developed. Development efforts focused on addressing several key issues including the supply and quality of the critical raw material tropinone, improvements in the stereoselective formation of 3-endo-tropanamine, and the compatibility with existing manufacturing capabilities of process requirements for the Claisen rearrangement used to produce a crucial benzofuran intermediate. The results of these studies and an improved route to zatosetron maleate are described.
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25
Total citations:
25
Citations from 2024:
2
(8%)
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MLA
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GOST
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Burks J. E. et al. Development of a Manufacturing Process for Zatosetron Maleate // Organic Process Research and Development. 1997. Vol. 1. No. 3. pp. 198-210.
GOST all authors (up to 50)
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Burks J. E., Espinosa L., LaBell E. S., Mcgill J. M., Ritter A. R., Speakman J. L., WILLIAMS M., Bradley D. A., Haehl M. G., Schmid C. R. Development of a Manufacturing Process for Zatosetron Maleate // Organic Process Research and Development. 1997. Vol. 1. No. 3. pp. 198-210.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1021/op970101q
UR - https://doi.org/10.1021/op970101q
TI - Development of a Manufacturing Process for Zatosetron Maleate
T2 - Organic Process Research and Development
AU - Burks, John E
AU - Espinosa, Leandro
AU - LaBell, Elizabeth S
AU - Mcgill, John M
AU - Ritter, Allen R
AU - Speakman, Jeffery L
AU - WILLIAMS, MARYANNE
AU - Bradley, David A.
AU - Haehl, Moira G
AU - Schmid, Christopher R
PY - 1997
DA - 1997/05/01
PB - American Chemical Society (ACS)
SP - 198-210
IS - 3
VL - 1
SN - 1083-6160
SN - 1520-586X
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{1997_Burks,
author = {John E Burks and Leandro Espinosa and Elizabeth S LaBell and John M Mcgill and Allen R Ritter and Jeffery L Speakman and MARYANNE WILLIAMS and David A. Bradley and Moira G Haehl and Christopher R Schmid},
title = {Development of a Manufacturing Process for Zatosetron Maleate},
journal = {Organic Process Research and Development},
year = {1997},
volume = {1},
publisher = {American Chemical Society (ACS)},
month = {may},
url = {https://doi.org/10.1021/op970101q},
number = {3},
pages = {198--210},
doi = {10.1021/op970101q}
}
Cite this
MLA
Copy
Burks, John E., et al. “Development of a Manufacturing Process for Zatosetron Maleate.” Organic Process Research and Development, vol. 1, no. 3, May. 1997, pp. 198-210. https://doi.org/10.1021/op970101q.