volume 66 issue 9 pages 1566-1571

Differential Pulsed Voltammetric Determination of RNA at the Picomole Level in the Presence of DNA and Nucleic Acid Components

Emil Palecek
Miroslav Fojta
Publication typeJournal Article
Publication date1994-04-01
scimago Q1
wos Q1
SJR1.533
CiteScore11.6
Impact factor6.7
ISSN00032700, 15206882, 21542686
Analytical Chemistry
Abstract
A procedure for determination of nanogram quantities of RNA in the presence of an excess of DNA and monomeric nucleic acid constituents is presented. The procedure is based on immobilization of RNA by incubation of a hanging mercury drop electrode in a 5-μL sample followed by washing and transfer of the nucleic acid-modified electrode in a voltammetric cell containing blank background electrolyte. The differential pulse voltammetric response of RNA differs from that of DNA. This makes it possible to determine traces (less than 1%) of RNA in DNA samples. Low molecular mass substances such as bases, nucleosides, and nucleotides do not interfere with the RNA determination as they do not adsorb at the electrode surface or are removed during the washing step. The limit of detection is below 100 pg of RNA
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Palecek E., Fojta M. Differential Pulsed Voltammetric Determination of RNA at the Picomole Level in the Presence of DNA and Nucleic Acid Components // Analytical Chemistry. 1994. Vol. 66. No. 9. pp. 1566-1571.
GOST all authors (up to 50) Copy
Palecek E., Fojta M. Differential Pulsed Voltammetric Determination of RNA at the Picomole Level in the Presence of DNA and Nucleic Acid Components // Analytical Chemistry. 1994. Vol. 66. No. 9. pp. 1566-1571.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1021/ac00081a033
UR - https://doi.org/10.1021/ac00081a033
TI - Differential Pulsed Voltammetric Determination of RNA at the Picomole Level in the Presence of DNA and Nucleic Acid Components
T2 - Analytical Chemistry
AU - Palecek, Emil
AU - Fojta, Miroslav
PY - 1994
DA - 1994/04/01
PB - American Chemical Society (ACS)
SP - 1566-1571
IS - 9
VL - 66
SN - 0003-2700
SN - 1520-6882
SN - 2154-2686
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{1994_Palecek,
author = {Emil Palecek and Miroslav Fojta},
title = {Differential Pulsed Voltammetric Determination of RNA at the Picomole Level in the Presence of DNA and Nucleic Acid Components},
journal = {Analytical Chemistry},
year = {1994},
volume = {66},
publisher = {American Chemical Society (ACS)},
month = {apr},
url = {https://doi.org/10.1021/ac00081a033},
number = {9},
pages = {1566--1571},
doi = {10.1021/ac00081a033}
}
MLA
Cite this
MLA Copy
Palecek, Emil, and Miroslav Fojta. “Differential Pulsed Voltammetric Determination of RNA at the Picomole Level in the Presence of DNA and Nucleic Acid Components.” Analytical Chemistry, vol. 66, no. 9, Apr. 1994, pp. 1566-1571. https://doi.org/10.1021/ac00081a033.