Open Access

Analytical Chemistry

, volume 92 , issue 12 , pages 8010-8014

In Vitro and In Vivo Electrochemical Measurement of Reactive Oxygen Species After Treatment with Anticancer Drugs

Alexander N. Vaneev ^{1, 2}

Peter Gorelkin ¹

A. S. Garanina ¹

Helena V Lopatukhina ²

Stepan S Vodopyanov ^{1, 2}

Anna V Alova ^{1, 2}

Oxana O. Ryabaya ³

Roman A. Akasov ^{1, 4}

Yanjun Zhang ^{5, 6}

Pavel Novak ^{1, 6}

Sergey V Salikhov ¹

Maxim A. Abakumov ⁷

Yasufumi Takahashi ⁸

Christopher R.W. Edwards ⁶

Natalia L. Klyachko ²

Alexander G. Majouga ^{1, 2, 9}

Yuri Korchev ^{1, 6}

Alexander V. Erofeev ^{1, 2}

Hide authors affiliations Show authors affiliations: 9 affiliations

National University of Science and Technology “MISiS”, Leninskiy Avenue, 4, Moscow 119049, Russia |

Lomonosov Moscow State University, Chemistry Department, Leninskie Gory, 1, 3, Moscow 119991, Russia |

N. N. Blokhin National Medical Research Center of Oncology, 24 Kashirskoe shosse, Moscow 115478, Russia |

⁴

I. M. Sechenov First Moscow State Medical University, Trubetskaya Str. 8-2, Moscow 119991, Russia |

⁵

Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin 300052, China |

⁶

Imperial College London, Department of Medicine, London W12 0NN, United Kingdom |

⁷

N. I. Pirogov Russian National Research Medical University, Ostrovityanova Street 1/7, Moscow 117997, Russia |

⁸

Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan |

⁹

D. Mendeleev University of Chemical Technology of Russia, Miusskaya Square, 9, Moscow 125047, Russia |

Publication type: Journal Article

Publication date: 2020-05-22

American Chemical Society (ACS)

Analytical Chemistry

scimago Q1

wos Q1

SJR: 1.533

CiteScore: 11.6

Impact factor: 6.7

ISSN: 00032700, 15206882, 21542686

DOI: 10.1021/acs.analchem.0c01256

Copy DOI

PubMed ID: 32441506

Analytical Chemistry

Abstract

In vivo monitoring of reactive oxygen species (ROS) in tumors during treatment with anticancer therapy is important for understanding the mechanism of action and in the design of new anticancer drugs. In this work, a platinized nanoelectrode is placed into a single cell for detection of the ROS signal, and drug-induced ROS production is then recorded. The main advantages of this method are the short incubation time with the drug, and its high sensitivity which allows the detection of low intracellular ROS concentrations. We have shown that our new method can measure the ROS response to chemotherapy in tumor-bearing mice in real-time. ROS levels were measured in vivo inside the tumor at different depths in response to doxorubicin. This work provides an effective new approach for the measurement of intracellular ROS by platinized nanoelectrodes.

Found

18 citations

Timoshenko Roman

28 publications, 241 citations

h-index: 10

10 citations

Krasnovskaya Olga

52 publications, 862 citations, 10 reviews

h-index: 17

Lomonosov Moscow State University

9 citations

Beloglazkina Elena

DSc in Chemistry, professor

296 publications, 3 214 citations, 11 reviews

h-index: 29

Lomonosov Moscow State University

8 citations

Akasov Roman

🥼 🤝

PhD in Biological/biomedical sciences

73 publications, 1 270 citations, 26 reviews

h-index: 22

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences

Kurchatov Complex of Crystallography and Photonics of NRC «Kurchatov Institute»

Sechenov First Moscow State Medical University

6 citations

Skvortsov Dmitry

🥼

PhD in Chemistry

128 publications, 1 834 citations, 1 review

h-index: 26

Lomonosov Moscow State University

5 citations

Salikhov Sergey

PhD in Physics and Mathematics, associate professor

26 publications, 333 citations

h-index: 8

National University of Science & Technology (MISiS)

Research interests

Materials Science

Symmetry

X-ray diffraction analysis

3 citations

Mazur Dmitrii

🤝

PhD in Chemistry

66 publications, 766 citations, 2 reviews

h-index: 18

Lomonosov Moscow State University

Shenzhen MSU-BIT University

Research interests

Astrochemistry

Bioorganic chemistry

Disinfection of water

Ecology

Environmental Chemistry

Environmental Science

Mass Spectrometry

Organic Chemistry

Peptides

Synthetic Organic Chemistry

3 citations

Kuzmin Vladimir

393 publications, 2 905 citations

h-index: 26

Emanuel Institute of Biochemical Physics of the Russian Academy of Sciences

2 citations

Abakumov Maxim

PhD in Chemistry, associate professor

159 publications, 2 662 citations, 19 reviews

h-index: 28

National University of Science & Technology (MISiS)

Pirogov Russian National Research Medical University

2 citations

Kuptsov Konstantin

PhD in Engineering

39 publications, 578 citations, 26 reviews

h-index: 15

National University of Science & Technology (MISiS)

Electrochemical corrosion

Physical vapor deposition

Plasma Physics

Processing of materials with pulsed plasma

Tribocorrosion

Tribology

2 citations

Vadekhina Veronika

10 publications, 17 citations

h-index: 2

Serbsky National Medical Research Center for Psychiatry and Narcology

National University of Science & Technology (MISiS)

Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences

Pirogov Russian National Research Medical University

1 citation

Vatsadze Sergey

DSc in Chemistry, professor, professor of the Russian Academy of Sciences

169 publications, 2 094 citations, 9 reviews

h-index: 20

N.D. Zelinsky Institute of Organic Chemistry of the Russian Academy of Sciences

Research interests

Supramolecular chemistry

1 citation

Soldatov Mikhail

PhD

99 publications, 2 385 citations

h-index: 25

Southern Federal University

1 citation

Trigub Alexander

PhD in Physics and Mathematics

183 publications, 2 216 citations

h-index: 27

National Research Centre "Kurchatov Institute"

Research interests

X-ray absorption spectroscopy

1 citation

Bunin Dmitry

PhD in Chemistry

15 publications, 190 citations

h-index: 7

A.N. Frumkin Institute of Physical Chemistry and Electrochemistry of the Russian Academy of Sciences

Research interests

Coordination chemistry

Photodynamic Therapy (PDT)

Photosensitizers

Photothermal therapy (PTT)

Phthalocyanines

Reactive oxygen species

Singlet oxygen

Supramolecular chemistry

1 citation

Permyakova Elizaveta

55 publications, 959 citations, 5 reviews

h-index: 19

National University of Science & Technology (MISiS)

1 citation

Dubrovin Evgeniy

DSc in Physics and Mathematics

54 publications, 651 citations, 5 reviews

h-index: 14

Lomonosov Moscow State University

Sirius University of Science and Technology

1 citation

Chmelyuk Nelly

25 publications, 201 citations

h-index: 8

National University of Science & Technology (MISiS)

Pirogov Russian National Research Medical University

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Cite this

GOST |

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GOST Copy

Vaneev A. N. et al. In Vitro and In Vivo Electrochemical Measurement of Reactive Oxygen Species After Treatment with Anticancer Drugs // Analytical Chemistry. 2020. Vol. 92. No. 12. pp. 8010-8014.

GOST all authors (up to 50) Copy

Vaneev A. N., Gorelkin P., Garanina A. S., Lopatukhina H. V., Vodopyanov S. S., Alova A. V., Ryabaya O. O., Akasov R. A., Zhang Y., Novak P., Salikhov S. V., Abakumov M. A., Takahashi Y., Edwards C. R., Klyachko N. L., Majouga A. G., Korchev Y., Erofeev A. V. In Vitro and In Vivo Electrochemical Measurement of Reactive Oxygen Species After Treatment with Anticancer Drugs // Analytical Chemistry. 2020. Vol. 92. No. 12. pp. 8010-8014.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1021/acs.analchem.0c01256

UR - https://doi.org/10.1021/acs.analchem.0c01256

TI - In Vitro and In Vivo Electrochemical Measurement of Reactive Oxygen Species After Treatment with Anticancer Drugs

T2 - Analytical Chemistry

AU - Vaneev, Alexander N.

AU - Gorelkin, Peter

AU - Garanina, A. S.

AU - Lopatukhina, Helena V

AU - Vodopyanov, Stepan S

AU - Alova, Anna V

AU - Ryabaya, Oxana O.

AU - Akasov, Roman A.

AU - Zhang, Yanjun

AU - Novak, Pavel

AU - Salikhov, Sergey V

AU - Abakumov, Maxim A.

AU - Takahashi, Yasufumi

AU - Edwards, Christopher R.W.

AU - Klyachko, Natalia L.

AU - Majouga, Alexander G.

AU - Korchev, Yuri

AU - Erofeev, Alexander V.

PY - 2020

DA - 2020/05/22

PB - American Chemical Society (ACS)

SP - 8010-8014

IS - 12

VL - 92

PMID - 32441506

SN - 0003-2700

SN - 1520-6882

SN - 2154-2686

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2020_Vaneev,

author = {Alexander N. Vaneev and Peter Gorelkin and A. S. Garanina and Helena V Lopatukhina and Stepan S Vodopyanov and Anna V Alova and Oxana O. Ryabaya and Roman A. Akasov and Yanjun Zhang and Pavel Novak and Sergey V Salikhov and Maxim A. Abakumov and Yasufumi Takahashi and Christopher R.W. Edwards and Natalia L. Klyachko and Alexander G. Majouga and Yuri Korchev and Alexander V. Erofeev},

title = {In Vitro and In Vivo Electrochemical Measurement of Reactive Oxygen Species After Treatment with Anticancer Drugs},

journal = {Analytical Chemistry},

year = {2020},

volume = {92},

publisher = {American Chemical Society (ACS)},

month = {may},

url = {https://doi.org/10.1021/acs.analchem.0c01256},

number = {12},

pages = {8010--8014},

doi = {10.1021/acs.analchem.0c01256}

}

MLA

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MLA Copy

Vaneev, Alexander N., et al. “In Vitro and In Vivo Electrochemical Measurement of Reactive Oxygen Species After Treatment with Anticancer Drugs.” Analytical Chemistry, vol. 92, no. 12, May. 2020, pp. 8010-8014. https://doi.org/10.1021/acs.analchem.0c01256.

Publisher

American Chemical Society (ACS)

Journal

Analytical Chemistry

scimago Q1

wos Q1

SJR

1.533

CiteScore

11.6

Impact factor

6.7

ISSN

00032700 (Print)

15206882 (Electronic)

21542686 (Print)

Labs

Biomedical Nanomaterials Laboratory

Profiles