Open Access
Analytical Chemistry, volume 92, issue 12, pages 8010-8014
In Vitro and In Vivo Electrochemical Measurement of Reactive Oxygen Species After Treatment with Anticancer Drugs
Vaneev Alexander N.
1, 2
,
Gorelkin Peter
2
,
Garanina A. S.
2
,
Lopatukhina Helena V
1
,
Vodopyanov Stepan S
1, 2
,
Alova Anna V
1, 2
,
Ryabaya Oxana O.
3
,
Akasov Roman A.
2, 4
,
Zhang Yanjun
5, 6
,
Novak Pavel
2, 5
,
Salikhov Sergey V
2
,
Edwards Christopher R.W.
5
,
Majouga Alexander G.
1, 2, 9
,
Korchev Yuri
2, 5
,
Erofeev Alexander V.
1, 2
1
2
4
6
Publication type: Journal Article
Publication date: 2020-05-22
Journal:
Analytical Chemistry
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 7.4
ISSN: 00032700, 15206882, 21542686
Analytical Chemistry
Abstract
In vivo monitoring of reactive oxygen species (ROS) in tumors during treatment with anticancer therapy is important for understanding the mechanism of action and in the design of new anticancer drugs. In this work, a platinized nanoelectrode is placed into a single cell for detection of the ROS signal, and drug-induced ROS production is then recorded. The main advantages of this method are the short incubation time with the drug, and its high sensitivity which allows the detection of low intracellular ROS concentrations. We have shown that our new method can measure the ROS response to chemotherapy in tumor-bearing mice in real-time. ROS levels were measured in vivo inside the tumor at different depths in response to doxorubicin. This work provides an effective new approach for the measurement of intracellular ROS by platinized nanoelectrodes.
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1 publication, 1.75%
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1 publication, 1.75%
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|
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1 publication, 1.75%
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1
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3
4
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Citations by publishers
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2
4
6
8
10
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|
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10 publications, 17.54%
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|
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10 publications, 17.54%
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9 publications, 15.79%
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|
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4 publications, 7.02%
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Springer Nature
|
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4 publications, 7.02%
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Wiley
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3 publications, 5.26%
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2 publications, 3.51%
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Hindawi Limited
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2 publications, 3.51%
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IEEE
|
IEEE
1 publication, 1.75%
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SAGE
|
SAGE
1 publication, 1.75%
|
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Pleiades Publishing
|
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1 publication, 1.75%
|
|
Xi'an Jiaotong University
|
Xi'an Jiaotong University, 1, 1.75%
Xi'an Jiaotong University
1 publication, 1.75%
|
|
Future Medicine
|
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1 publication, 1.75%
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2
4
6
8
10
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Vaneev A. N. et al. In Vitro and In Vivo Electrochemical Measurement of Reactive Oxygen Species After Treatment with Anticancer Drugs // Analytical Chemistry. 2020. Vol. 92. No. 12. pp. 8010-8014.
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Vaneev A. N., Gorelkin P., Garanina A. S., Lopatukhina H. V., Vodopyanov S. S., Alova A. V., Ryabaya O. O., Akasov R. A., Zhang Y., Novak P., Salikhov S. V., Abakumov M. A., Takahashi Y., Edwards C. R., Klyachko N. L., Majouga A. G., Korchev Y., Erofeev A. V. In Vitro and In Vivo Electrochemical Measurement of Reactive Oxygen Species After Treatment with Anticancer Drugs // Analytical Chemistry. 2020. Vol. 92. No. 12. pp. 8010-8014.
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RIS
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TY - JOUR
DO - 10.1021/acs.analchem.0c01256
UR - https://doi.org/10.1021%2Facs.analchem.0c01256
TI - In Vitro and In Vivo Electrochemical Measurement of Reactive Oxygen Species After Treatment with Anticancer Drugs
T2 - Analytical Chemistry
AU - Alova, Anna V
AU - Zhang, Yanjun
AU - Salikhov, Sergey V
AU - Edwards, Christopher R.W.
AU - Lopatukhina, Helena V
AU - Vaneev, Alexander N.
AU - Takahashi, Yasufumi
AU - Majouga, Alexander G.
AU - Gorelkin, Peter
AU - Garanina, A. S.
AU - Vodopyanov, Stepan S
AU - Ryabaya, Oxana O.
AU - Akasov, Roman A.
AU - Novak, Pavel
AU - Abakumov, Maxim A.
AU - Klyachko, Natalia L.
AU - Korchev, Yuri
AU - Erofeev, Alexander V.
PY - 2020
DA - 2020/05/22 00:00:00
PB - American Chemical Society (ACS)
SP - 8010-8014
IS - 12
VL - 92
SN - 0003-2700
SN - 1520-6882
SN - 2154-2686
ER -
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@article{2020_Vaneev,
author = {Anna V Alova and Yanjun Zhang and Sergey V Salikhov and Christopher R.W. Edwards and Helena V Lopatukhina and Alexander N. Vaneev and Yasufumi Takahashi and Alexander G. Majouga and Peter Gorelkin and A. S. Garanina and Stepan S Vodopyanov and Oxana O. Ryabaya and Roman A. Akasov and Pavel Novak and Maxim A. Abakumov and Natalia L. Klyachko and Yuri Korchev and Alexander V. Erofeev},
title = {In Vitro and In Vivo Electrochemical Measurement of Reactive Oxygen Species After Treatment with Anticancer Drugs},
journal = {Analytical Chemistry},
year = {2020},
volume = {92},
publisher = {American Chemical Society (ACS)},
month = {may},
url = {https://doi.org/10.1021%2Facs.analchem.0c01256},
number = {12},
pages = {8010--8014},
doi = {10.1021/acs.analchem.0c01256}
}
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MLA
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Vaneev, Alexander N., et al. “In Vitro and In Vivo Electrochemical Measurement of Reactive Oxygen Species After Treatment with Anticancer Drugs.” Analytical Chemistry, vol. 92, no. 12, May. 2020, pp. 8010-8014. https://doi.org/10.1021%2Facs.analchem.0c01256.