Analytical Chemistry, volume 92, issue 13, pages 9330-9337
Harnessing Selectivity and Sensitivity in Electronic Biosensing: A Novel Lab-on-Chip Multigate Organic Transistor
Vitaliy Parkula
1, 2
,
Marcello Berto
1
,
Chiara Diacci
1, 3
,
Bianca Patrahau
1, 4
,
Michele Di Lauro
1, 5
,
Alessandro Kovtun
6
,
A. Liscio
7
,
Matteo Sensi
1
,
Paolo Samorì
4
,
Pierpaolo Greco
2
,
Carlo Bortolotti
1
,
F. Biscarini
1, 5
2
Scriba Nanotecnologie S.r.l., Via di Corticella 1838, 40128 Bologna, Italy
|
6
Istituto per la Sintesi Organica e la Fotoreattività, CNR, Via Piero Gobetti, 101, 40129 Bologna, Italy
|
Publication type: Journal Article
Publication date: 2020-06-02
Journal:
Analytical Chemistry
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 7.4
ISSN: 00032700, 15206882, 21542686
PubMed ID:
32483968
Analytical Chemistry
Abstract
Electrolyte gated organic transistors can operate as powerful ultrasensitive biosensors, and efforts are currently devoted to devising strategies for reducing the contribution of hardly avoidable, nonspecific interactions to their response, to ultimately harness selectivity in the detection process. We report a novel lab-on-a-chip device integrating a multigate electrolyte gated organic field-effect transistor (EGOFET) with a 6.5 μL microfluidics set up capable to provide an assessment of both the response reproducibility, by enabling measurement in triplicate, and of the device selectivity through the presence of an internal reference electrode. As proof-of-concept, we demonstrate the efficient operation of our pentacene based EGOFET sensing platform through the quantification of tumor necrosis factor alpha with a detection limit as low as 3 pM. Sensing of inflammatory cytokines, which also include TNFα, is of the outmost importance for monitoring a large number of diseases. The multiplexable organic electronic lab-on-chip provides a statistically solid, reliable, and selective response on microliters sample volumes on the minutes time scale, thus matching the relevant key-performance indicators required in point-of-care diagnostics.
Top-30
Citations by journals
1
2
3
4
|
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Biosensors and Bioelectronics
4 publications, 10.81%
|
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ACS applied materials & interfaces
2 publications, 5.41%
|
|
Biosensors
2 publications, 5.41%
|
|
Advanced Materials
2 publications, 5.41%
|
|
Chemosensors
1 publication, 2.7%
|
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Applied Surface Science
1 publication, 2.7%
|
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Organic Electronics
1 publication, 2.7%
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Advanced Materials Technologies
1 publication, 2.7%
|
|
Advanced healthcare materials
1 publication, 2.7%
|
|
View
1 publication, 2.7%
|
|
Advanced Materials Interfaces
1 publication, 2.7%
|
|
Analytical Chemistry
1 publication, 2.7%
|
|
Lab on a Chip
1 publication, 2.7%
|
|
Chemical Reviews
1 publication, 2.7%
|
|
IEEE Journal on Flexible Electronics
1 publication, 2.7%
|
|
Science advances
1 publication, 2.7%
|
|
Chemistry - A European Journal
1 publication, 2.7%
|
|
Analytica Chimica Acta
1 publication, 2.7%
|
|
Sensors
1 publication, 2.7%
|
|
Bioelectronic Medicine
1 publication, 2.7%
|
|
Sensors and Actuators, B: Chemical
1 publication, 2.7%
|
|
Advanced Functional Materials
1 publication, 2.7%
|
|
Cell Reports Physical Science
1 publication, 2.7%
|
|
Russian Chemical Reviews
1 publication, 2.7%
|
|
Critical Reviews in Analytical Chemistry
1 publication, 2.7%
|
|
Wearable Electronics
1 publication, 2.7%
|
|
Chinese Chemical Letters
1 publication, 2.7%
|
|
1
2
3
4
|
Citations by publishers
2
4
6
8
10
12
|
|
Elsevier
11 publications, 29.73%
|
|
Wiley
8 publications, 21.62%
|
|
American Chemical Society (ACS)
4 publications, 10.81%
|
|
Multidisciplinary Digital Publishing Institute (MDPI)
4 publications, 10.81%
|
|
IEEE
2 publications, 5.41%
|
|
Royal Society of Chemistry (RSC)
1 publication, 2.7%
|
|
American Association for the Advancement of Science (AAAS)
1 publication, 2.7%
|
|
Springer Nature
1 publication, 2.7%
|
|
Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii
1 publication, 2.7%
|
|
Taylor & Francis
1 publication, 2.7%
|
|
2
4
6
8
10
12
|
- We do not take into account publications without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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GOST
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Parkula V. et al. Harnessing Selectivity and Sensitivity in Electronic Biosensing: A Novel Lab-on-Chip Multigate Organic Transistor // Analytical Chemistry. 2020. Vol. 92. No. 13. pp. 9330-9337.
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Parkula V., Berto M., Diacci C., Patrahau B., Di Lauro M., Kovtun A., Liscio A., Sensi M., Samorì P., Greco P., Bortolotti C., Biscarini F. Harnessing Selectivity and Sensitivity in Electronic Biosensing: A Novel Lab-on-Chip Multigate Organic Transistor // Analytical Chemistry. 2020. Vol. 92. No. 13. pp. 9330-9337.
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TY - JOUR
DO - 10.1021/acs.analchem.0c01655
UR - https://doi.org/10.1021/acs.analchem.0c01655
TI - Harnessing Selectivity and Sensitivity in Electronic Biosensing: A Novel Lab-on-Chip Multigate Organic Transistor
T2 - Analytical Chemistry
AU - Patrahau, Bianca
AU - Berto, Marcello
AU - Di Lauro, Michele
AU - Kovtun, Alessandro
AU - Sensi, Matteo
AU - Samorì, Paolo
AU - Bortolotti, Carlo
AU - Biscarini, F.
AU - Parkula, Vitaliy
AU - Diacci, Chiara
AU - Liscio, A.
AU - Greco, Pierpaolo
PY - 2020
DA - 2020/06/02 00:00:00
PB - American Chemical Society (ACS)
SP - 9330-9337
IS - 13
VL - 92
PMID - 32483968
SN - 0003-2700
SN - 1520-6882
SN - 2154-2686
ER -
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@article{2020_Parkula,
author = {Bianca Patrahau and Marcello Berto and Michele Di Lauro and Alessandro Kovtun and Matteo Sensi and Paolo Samorì and Carlo Bortolotti and F. Biscarini and Vitaliy Parkula and Chiara Diacci and A. Liscio and Pierpaolo Greco},
title = {Harnessing Selectivity and Sensitivity in Electronic Biosensing: A Novel Lab-on-Chip Multigate Organic Transistor},
journal = {Analytical Chemistry},
year = {2020},
volume = {92},
publisher = {American Chemical Society (ACS)},
month = {jun},
url = {https://doi.org/10.1021/acs.analchem.0c01655},
number = {13},
pages = {9330--9337},
doi = {10.1021/acs.analchem.0c01655}
}
Cite this
MLA
Copy
Parkula, Vitaliy, et al. “Harnessing Selectivity and Sensitivity in Electronic Biosensing: A Novel Lab-on-Chip Multigate Organic Transistor.” Analytical Chemistry, vol. 92, no. 13, Jun. 2020, pp. 9330-9337. https://doi.org/10.1021/acs.analchem.0c01655.