Analytical Chemistry, volume 94, issue 17, pages 6615-6620
Single Molecule Level and Label-Free Determination of Multibiomarkers with an Organic Field-Effect Transistor Platform in Early Cancer Diagnosis
Chenfang Sun
1
,
Guangyuan Feng
1
,
Yaru Song
1
,
Shanshan Cheng
1, 2, 3
,
Sheng-Bin Lei
1, 2, 3
,
Wenping Hu
1, 2, 3, 4
3
Haihe Laboratory of Sustainable Chemical Transformations, Tianjin 300192, China
|
Publication type: Journal Article
Publication date: 2022-04-21
Journal:
Analytical Chemistry
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 7.4
ISSN: 00032700, 15206882, 21542686
Analytical Chemistry
Abstract
The single molecule level determination with a transistor (SiMoT) platform has attracted considerable attention in the recognition of various ultralow abundance biomolecules, while complicated labeling and testing processes limit its further applications. Recently, organic field-effect transistor (OFET)-based biosensors are good candidates for constructing an advanced label-free SiMoT platform due to their facile fabrication process, rapid response time, and low sample volume with a wide range of detection. However, the sensitivity of most OFET-based biosensors is in the order of nM and pM, which cannot meet the detection requirements of ultralow abundance protein. Herein, a label-free SiMoT platform is demonstrated by integrating pillar[n]arene as a signal amplifier, and the detection limit can reach 4.75 aM. Besides, by simultaneous determination of α-fetoprotein, carcinoembryonic antigen, and prostate antigen, the proposed multiplexed OFET-based SiMoT platform provides a key step in reliable early cancer diagnosis.
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Citations by publishers
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1 publication, 9.09%
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1 publication, 9.09%
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- We do not take into account publications without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Sun C. et al. Single Molecule Level and Label-Free Determination of Multibiomarkers with an Organic Field-Effect Transistor Platform in Early Cancer Diagnosis // Analytical Chemistry. 2022. Vol. 94. No. 17. pp. 6615-6620.
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Sun C., Feng G., Song Y., Cheng S., Lei S., Hu W. Single Molecule Level and Label-Free Determination of Multibiomarkers with an Organic Field-Effect Transistor Platform in Early Cancer Diagnosis // Analytical Chemistry. 2022. Vol. 94. No. 17. pp. 6615-6620.
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TY - JOUR
DO - 10.1021/acs.analchem.2c00897
UR - https://doi.org/10.1021/acs.analchem.2c00897
TI - Single Molecule Level and Label-Free Determination of Multibiomarkers with an Organic Field-Effect Transistor Platform in Early Cancer Diagnosis
T2 - Analytical Chemistry
AU - Sun, Chenfang
AU - Feng, Guangyuan
AU - Song, Yaru
AU - Cheng, Shanshan
AU - Lei, Sheng-Bin
AU - Hu, Wenping
PY - 2022
DA - 2022/04/21 00:00:00
PB - American Chemical Society (ACS)
SP - 6615-6620
IS - 17
VL - 94
SN - 0003-2700
SN - 1520-6882
SN - 2154-2686
ER -
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@article{2022_Sun,
author = {Chenfang Sun and Guangyuan Feng and Yaru Song and Shanshan Cheng and Sheng-Bin Lei and Wenping Hu},
title = {Single Molecule Level and Label-Free Determination of Multibiomarkers with an Organic Field-Effect Transistor Platform in Early Cancer Diagnosis},
journal = {Analytical Chemistry},
year = {2022},
volume = {94},
publisher = {American Chemical Society (ACS)},
month = {apr},
url = {https://doi.org/10.1021/acs.analchem.2c00897},
number = {17},
pages = {6615--6620},
doi = {10.1021/acs.analchem.2c00897}
}
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Sun, Chenfang, et al. “Single Molecule Level and Label-Free Determination of Multibiomarkers with an Organic Field-Effect Transistor Platform in Early Cancer Diagnosis.” Analytical Chemistry, vol. 94, no. 17, Apr. 2022, pp. 6615-6620. https://doi.org/10.1021/acs.analchem.2c00897.